Clinical trials: Closed Head Trauma
Traumatic Brain Injury
Internet-based Interacting Together Everyday, Recovery After Childhood TBI (I-InTERACT)--RRTC
The purpose of this study is to test two on-line interventions for families of young children who have experienced moderate or severe traumatic brain injury (TBI).
- Trial name
- I-InTERACT (NCT01214694)
- Testing
- Internet-based Interacting Together Everyday: Recovery After Childhood TBI (I-InTERACT), Internet-based-Interacting Together Everyday, Recovery after Childhood TBI Express (I-InTERACT Express), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 117 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Hyperbaric Oxygen Therapy, Traumatic Brain Injury
Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children
Due its high incidence, mTBI and its consequences of PPCS are a major public health issue. There is no consensus regarding the treatment of PPCS in pediatrics.
- Conditions
- Hyperbaric Oxygen Therapy, Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- TBIPED (NCT03339037)
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Assaf-Harofeh Medical Center
Wounds and Injuries, Closed Head Injury
Study of Sand Versus Wood Chip Surfaces on School Playgrounds to Minimize Injury in School Children
This study will compare children's injury rates (arm fracture, head injury and other injuries) when playing on playground equipment on granite sand versus wood fibre playing surfaces.
- Trial name
- NCT00213174
- Testing
- school playgrounds
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- The Hospital for Sick Children
Concussion, Brain
Development of a Concussion Management Platform for Children and Youth
This multi-centred, randomized controlled trial will evaluate the effectiveness of a pilot tested mobile device Application built to guide youth in recovery from concussion.
- Trial name
- Back2PlayApp (NCT05471791)
- Testing
- Back2Play App
- Where
- 2 sites in Canada
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- McMaster University
Post Concussion Syndrome
Accelerated, Theta-burst Stimulation for the Treatment of Post-concussion Syndrome
TMS has been safely and reliably delivered at the Harquail Centre for over 5 years, with a primary focus on conventional rTMS protocols for treatment-resistant depression.
- Trial name
- NCT06031662
- Testing
- Intermittent Theta-Burst Stimulation
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Sunnybrook Health Sciences Centre
Brain Concussion, Brain Injuries
Indirect Intracranial Pressure Measurement in Patients With Suspected or Documented Concussion
The HS-1000 is an innovative non-invasive monitoring device that employs advanced acoustic signal analysis to calculate ICP on a continuous basis.
- Trial name
- NCT02699359
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
Traumatic Brain Injury
TBI MR Study 3 Houston Methodist
This hypothesis-generating feasibility study to determine potential associations between a broad range of clinical neurological symptoms and Magnetic Resonance Image (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- NCT02218216
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- GE Healthcare
Traumatic Brain Injury, Post Concussive Symptoms
Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Patients with mild-moderate traumatic brain injury (TBI) sustained between 3 months and 5 years ago with prolonged postconcussive symptoms will be recruited.
- Conditions
- Traumatic Brain Injury, Post Concussive Symptoms, Depression, Executive Dysfunction
- Trial name
- NCT02613936
- Testing
- Anodal tDCS, Cognitive training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of New Mexico
Traumatic Brain Injury, Post-Concussion Syndrome
Fundamental and Applied Concussion Recovery Modality Research and Development: Applications for the Enhanced Recovery
This research is being done to understand the role of different recovery methods in healing time after athletic or sports related concussion.
- Conditions
- Traumatic Brain Injury, Post-Concussion Syndrome, Concussion, Brain
- Trial name
- NCT05062148
- Testing
- Float-REST, Photobiomodulation
- Where
- United States
- Sponsor
- West Virginia University
Brain Concussion, Blast Injuries
Metacognitive Training to Enhance Strategy Use in Blast-Related TBI
Enhanced Goal Management Training (GMT) is a 10-week group or individual therapy that teaches strategies to improve an individual's ability to complete everyday tasks.
- Trial name
- NCT00857207
- Testing
- Goal Management Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Post-Concussion Syndrome
Post-concussion Syndrome and Chiropractic
This proof-of-concept trial will explore the effects of manual chiropractic adjustments on nervous system function in individuals with post-concussion syndrome.
- Trial name
- PCS (NCT06151184)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Life University
Low-level Blast Exposure
Blast Overpressure Longitudinal Study
The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel.
- Trial name
- BLES (NCT07606651)
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International
Concussion, Mild, Convergence Insufficiency
Spectacles Lens in Concussed Kids
We will be looking at 3 treatment arms in the form of different type of glasses to see if one is superior to helping kids have sustained a concussion and are symptomatic.
- Conditions
- Concussion, Mild, Convergence Insufficiency, Accommodation; Insufficiency
- Trial name
- SLICK (NCT03123822)
- Testing
- Glasses
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
TBI (Traumatic Brain Injury), Concussion, Brain
Growth Hormone Replacement Therapy for Retried Professional Football Players
This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth…
- Conditions
- TBI (Traumatic Brain Injury), Concussion, Brain, Sport Injury, Anterior Pituitary Hyposecretion Syndrome
- Trial name
- NCT04121780
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Center for Neurological Studies
Dizziness, Concussion (Diagnosis)
Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Balance Behaviour
This research project aims to measure how balance is affected by special visual stimulation. Dizziness caused by complex moving visual patterns, known as optokinetic stimulation, is usually called visually induced dizziness…
- Conditions
- Dizziness, Concussion (Diagnosis), Traumatic Brain Injury, Balance Assessment
- Trial name
- NCT06893029
- Testing
- Postural Response upon physical optokinetic stimulation, Postural Response upon virtual optokinetic stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dominik Straumann
MTBI - Mild Traumatic Brain Injury
Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury
The proposed study tests the efficacy (Phase II) of 36 or 54 30-minute training sessions of PATH neurotraining followed by digit memory exercises to improve working memory, processing speed and attention in mTBI patients rapidly…
- Trial name
- NCT03655782
- Testing
- PATH + DigitMemory (DM) neurotraining
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Perception Dynamics Institute
Concussion
Cervicovestibular Physiotherapy and Aerobic Exercise in Concussion
Sport concussions are among the most commonly occurring injuries in sport and recreation and pose significant public health implications for Canadians.
- Trial name
- NCT02988323
- Testing
- Cervicovestibular Physio (CV PT), Low-Level Aerobic Exercise (LLAE), Combination (LLAE and CV PT)
- Volunteers
- 96 people
- Sponsor
- Sport Injury Prevention Research Centre
Mild Traumatic Brain Injury
Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI
This study is a parallel arm, double-blind, randomized, controlled clinical trial to assess the safety and efficacy of an experimental software program designed to improve cognitive functions versus a computer-based software…
- Trial name
- CogMind (NCT02922569)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Mindfulness Training
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Posit Science Corporation