Clinical trials: Closed Head Trauma
Musculoskeletal Injury
Post-Concussion Musculoskeletal Injury Risks
Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19…
- Trial name
- NCT05122728
- Testing
- Post-Concussion Neuromuscular Function and Musculoskeletal Injury Risk Assessment
- Where
- 3 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Concussion, Mild, Rehabilitation
The Effect of a Sub-symptom Threshold Aerobic Exercise Program on Recovery in Concussed Athletes
The purpose of this randomized controlled trial is to examine whether systematic sub-threshold exercise is effective in improving recovery time in athletes after sport related concussion (SRC) compared to those who participate in…
- Trial name
- NCT03865433
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rocky Mountain University of Health Professions
Concussion, Brain
Post-acute Structured Exercise Following Sport Concussion
This study will investigate the effect of structured, standardized aerobic exercise (AE) compared to usual care on clinical recovery from sport-related concussion (SRC) within the post-acute phase of injury.
- Trial name
- NCT02969824
- Testing
- Supervised Aerobic Exercise
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Toronto
Traumatic Brain Injury, Post-Concussion Syndrome
"Interactive Metronome Technology for Blast-Related Traumatic Brain Injury"
The purpose of this research is to see whether adding a new therapy helps people with brain injury focus better and think more clearly.
- Trial name
- NCT01248390
- Testing
- Interactive metronome
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Defense and Veterans Brain Injury Center
Post Concussion Syndrome
Effects of Vestibular Rehabilitation and Routine Physical Therapy in Athletes With Post Concussion Syndrome
This randomized controlled trial with a parallel design was conducted over six months at Ghurki Trust Teaching Hospital to compare the effects of Vestibular Rehabilitation and Routine Physical Therapy on stability, kinesiophobia…
- Trial name
- PCS BESS IPRRS (NCT07401706)
- Testing
- Intervention 1, Control Arm (Conventional Therapy)
- Volunteers
- 34 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Concussion, Brain
Feasibility of Aerobic Exercise for Recovery From Work-related Concussion
There is a lot of research on how to treat people with sport-related concussion. There has not been a lot of research on the treatment of injured workers with concussion.
- Trial name
- NCT06263179
- Testing
- Target Heartrate Aerobic Exercise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- State University of New York at Buffalo
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Concussion, Brain
Creatine Supplementation in Concussion Recovery
The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs.
- Trial name
- CSCR (NCT06208813)
- Testing
- Creatine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Diego State University
Concussion, Brain
The Effect of Screen Time on Recovery From Concussion
This study will prospectively examine the effect of screen time on recovery from concussion. Patients 12 to 25 years of age presenting to the ED with a concussion will be randomized to allow for screen time as tolerated or to…
- Trial name
- NCT03564210
- Testing
- Screen time permitted, Screen Time Abstain
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Theodore Macnow
Mild Traumatic Brain Injury; Concussion
Seeing-Moving-Playing: Early Rehabilitation Utilizing Visual and Vestibular Technology Following Traumatic Brain Injury
The aim of this research program is to 1) Evaluate potential problems with vision, inner ear-eye reflexes and deficits of processing eye information that occur following TBI; and 2) Evaluate treatment programs for individuals…
- Trial name
- SiMPlyRehab (NCT03215082)
- Testing
- Vestibular-Visual Intervention, standard care
- Where
- 4 sites in Canada, France and 1 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Concussion (Diagnosis), Gait Abnormality
Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery
Approximately 1.6 to 3.8 million mild traumatic brain injuries, or concussions, occur yearly in the United States. Although most individuals progress through return-to-activity (RTA) using symptom-guided aerobic and functional…
- Trial name
- NCT07801482
- Testing
- Exercise, Return to Activity Progression
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Illinois University
Mild Traumatic Brain Injury
Elucidate the Mechanisms, Development and Effectiveness of Balance Control and Gait Strategy After Mild Traumatic Brain Injury: Develop Innovative Design of Computerized Dual-task Balance Module
The purpose of this study is to innovatively design and develop computerized dual-task balance training modules and home modules, and conduct proactive clinical verification to focus on the effectiveness of balance control and…
- Trial name
- NCT05638659
- Testing
- Computerized dual-task balance and home program, Medical consultation and traditional balance training
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Mild Brain Traumatic Injury, Compliance, Patient
Interest of the S100B Protein Assay in Mild Traumatic Brain Injuries at the DOUAI Hospital
The main objective is to evaluate the feasibility and interest of setting up a protocol for the systematic measurement of the S100B protein in patients with mild traumatic brain injury admitted to the emergency room of Douai…
- Trial name
- PS100BTCL (NCT05285774)
- Where
- France
- Volunteers
- 258 people
- Sponsor
- Centre Hospitalier de Douai
Traumatic Brain Injury (TBI), Attention Deficit Hyperactivity Disorder (ADHD)
Attention Intervention Management
This is a research study to learn if a computer-based intervention that provides direct attention and metacognitive strategy development can improve attention, memory, and executive control in adolescents with moderate-to-severe…
- Conditions
- Traumatic Brain Injury (TBI), Attention Deficit Hyperactivity Disorder (ADHD), Head Injury, Brain Concussion
- Trial name
- AIM (NCT01779427)
- Testing
- AIM
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mild Traumatic Brain Injury, Dizziness
Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI
The goal of this clinical trial is to compare outcomes for standard vestibular rehabilitation home program to a digital vestibular rehabilitation home program in adults with dizziness related to mild traumatic brain injury…
- Trial name
- NCT06222450
- Testing
- Vestibular Rehabilitation Therapy (VRT)
- Where
- 3 sites in United States
- Volunteers
- 68 people
- Sponsor
- Mountain Home Research & Education Corporation
Mild Traumatic Brain Injury
Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial)
The purpose of this study is to evaluate improvement in balance after receiving physical therapy when augmented by CN-NINM than when augmented by a placebo (sham CN-NINM).
- Trial name
- CN-NINM (NCT02125591)
- Testing
- Active CN-NINM PoNS
- Where
- 2 sites in United States
- Sponsor
- U.S. Army Medical Research and Development Command
Brain Concussion, Mild Traumatic Brain Injury
Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury
Concussion or mild traumatic brain injury (mTBI) is a major public health concern. Most adolescents will recover from mTBI without complication; however, a sizeable minority experience symptoms that last more than one most…
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Concussion
- Trial name
- RESET (NCT07698015)
- Testing
- Mindfulness-based intervention, Health Education
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Molly Cairncross
Brain Concussion
Tele-Rehabilitation to Improve Mild Traumatic Brain Injury Recovery and Reduce Subsequent Injury Risk
The goal of this clinical trial is to examine the feasibility, utility, and efficacy of a smartphone-based assessment battery and remotely administered virtual Neuromuscular/Dual-Task (vNDT) intervention among healthy U.S.
- Trial name
- NCT05594225
- Testing
- Virtual Neuromuscular/Dual-Task Training
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Colorado, Denver
Concussion, Brain, Dynamic Vision Tests
A Comparison of Dynamic Vision Between College Athletes & Controls
The purpose of this study is to establish baseline reference values for tests of static and dynamic visual acuity and gaze stabilization in collegiate athletes and non-athletes, and to determine if there are differences in vision…
- Trial name
- NCT05819489
- Testing
- Dynamic Vision Testing
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Mild Traumatic Brain Injury, Concussion, Mild
Exercise as Concussion Therapy Trial- 2
This study is a Phase 2, open-label study of a therapeutic intervention (graded exercise)compared to a reference therapy (passive stretching) in patients who have sustained mTBI.
- Trial name
- ExACTT (NCT04578743)
- Testing
- Graded Exercise Therapy: ClearPlay(TM)
- Where
- 3 sites in Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- ANSwers Neuroscience, Inc.