Clinical trials: Closed Head Trauma
Brain Concussion, Post-Concussion Symptoms
Use of Salt-Water Solution to Improve Symptoms in Concussion
The purpose of this study is to find out if 3% hypertonic saline (salt-water solution) given in a vein improves the headache that may be caused by a concussion.
- Trial name
- NCT00142090
- Testing
- 3% Hypertonic saline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rady Children's Hospital, San Diego
Vestibular Disorder, Mild Traumatic Brain Injury
Randomized Controlled Trial for Vestibular Treatment in Concussion
A prospective, single-blind, four-group multi-center randomized controlled trial (RCT) of targeted rehabilitation exercises for vestibular symptoms and impairments (T-REV) in civilians with mild traumatic brain injury (mTBI) will…
- Trial name
- NCT03600324
- Testing
- T-REV
- Where
- 4 sites in United States
- Volunteers
- 121 people
- Sponsor
- University of Pittsburgh
Post Traumatic Stress Disorder, Mild Traumatic Brain Injury, Concussion
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with concurrent mild TBI and PTSD.
- Trial name
- NCT01921179
- Testing
- GOALS (Goal-Oriented Attentional Regulation), EDU (Brain Health Education)
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Brain Injury, Chronic
Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury
The purpose of this study is to examine whether 40 hyperbaric oxygen sessions has effect on long-term symptoms after brain injury.
- Trial name
- HYBOBI2 (NCT01986205)
- Testing
- Hyperbaric Oxygen, Minimal pressure air
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Lindell Weaver
Mild Traumatic Brain Injury (mTBI), Sports-related Concussion
Mobile Dual-Task Brain and Balance Intervention for Concussion Recovery
This research study examines recovery after a sports-related concussion or mild head injury. Many athletes experience lingering problems with thinking, balance, and mood months after a concussion.
- Conditions
- Mild Traumatic Brain Injury (mTBI), Sports-related Concussion, Heart Rate Variability (HRV), Walking
- Trial name
- NCT07599475
- Testing
- Home-Based Mobile Dual-Task Intervention (BraW-Day™)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hyunhwa Lee
Concussion, Brain
Oculomotor Function Testing in Acute Concussion
This is a prospective longitudinal study which aims to compare oculomotor function and visual scanning behaviour (VSB) of participants who suffered concussion with healthy controls with no concussion.
- Trial name
- NCT03892356
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after…
- Conditions
- Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
- Trial name
- NCT04124029
- Testing
- No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
PROtein S100B for Mild Trauma of the HEad in Emergency Patients
Brain injury is a frequent purpose for consultation in emergency services. Management of brain injury is time and resource consuming, combining clinical monitoring and imaging.
- Trial name
- PROMETHEE (NCT03313505)
- Testing
- S100B protein dosage, Brain CT scan
- Where
- 15 sites in France, Monaco
- Volunteers
- 787 people
- Sponsor
- Centre Hospitalier Princesse Grace
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Post-Concussion Syndrome, Post-Traumatic Headache
Digital Solutions for Concussion
The objective of this study is to develop new digital solutions for patients with prolonged postconcussion symptoms, and investigate its usability, feasibility, and safety.
- Trial name
- DiSCo (NCT05635656)
- Testing
- Digital symptom mapping and biofeedback treatment
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- St. Olavs Hospital
Mild Traumatic Brain Injury, Functional Neurological Disorder
Rehabilitation for Functional Memory Symptoms After Concussion
This study aims to evaluate the feasibility of novel cognitive behavioural therapy (CBT)-based intervention designed to improve functional memory symptoms after concussion.
- Trial name
- NCT05581810
- Testing
- Cognitive Behavioural Therapy (CBT), Cognitive Rehabilitation
- Where
- 10 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Concussions, Post-Concussive Symptoms
Pediatric Concussion Assessment of Rest and Exertion
The goal of this study is to investigate when is the best time to resume physical activity following a head injury. Two treatment plans will be studied; the first treatment plan consists of gradually reintroducing physical…
- Trial name
- PedCARE (NCT02893969)
- Testing
- Physical Activity, Rest
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Children's Hospital of Eastern Ontario
Mild Traumatic Brain Injury, Brain Concussion
Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury
The purpose of this single center, longitudinal, pilot study is to provide evidence for the use of an eye tracking system as an objective tool to identify mild traumatic brain injury (mTBI) related oculomotor dysfunction (OMD)…
- Conditions
- Mild Traumatic Brain Injury, Brain Concussion, Convergence Insufficiency, Accommodative Insufficiency
- Trial name
- NCT03319966
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Hennepin Healthcare Research Institute
Concussion, Mild, Autonomic Nervous System
Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
The goal of this clinical trial is to test a wearable device's effect on performance in tactical populations with a history of concussion.
- Conditions
- Concussion, Mild, Autonomic Nervous System, Cognitive
- Trial name
- NCT05675956
- Testing
- Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Concussion, Mild, Mild Traumatic Brain Injury
Post-Concussion Aerobic Exercise
This study is looking at the specific role of an exercise prescription on recovery from concussion symptoms in the general population.
- Trial name
- NCT04539509
- Testing
- Exercise Prescription, Treadmill Test, Monitoring
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Sport-related Concussion
Sub-acute Exercise Following Sport-Related Concussion
Determine the safety and efficacy of sub-maximal aerobic exercise during the subacute phase of recovery following sport-related concussion.
- Trial name
- NCT03575455
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Brain Injury, Traumatic
Mild Traumatic Brain Injury Registry
The purpose of the study is to gather information about patients with mild traumatic brain injury in order to develop guidelines for evaluation and treatment.
- Trial name
- mTBI (NCT01688869)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Treatment of Cognitive Deficits After Traumatic Brain Injury
Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury
Posttraumatic consequences are common causes of disability and long-term morbidity. They include cognitive dysfunction, seizures, headache, dizziness, fatigue, sensory deficits, neurodegeneration and psychiatric disorders (e.g.
- Trial name
- NCT06337994
- Testing
- Memantine Hydrochloride
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University