Clinical trials: Closed Head Trauma
Post-Concussion Symptoms, Concussion
Safety and Feasibility of Early Active Rehabilitation in Children After Concussion
It has been suggested that activity immediately following concussion is detrimental to recovery and may lead to long term impairments.
- Trial name
- NCT03103529
- Testing
- Active Rehabilitation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder
Transcranial Electrical Stimulation for mTBI
mTBI is a leading cause of sustained physical, cognitive, emotional, and behavioral deficits in OEF/OIF/OND Veterans and the general public.
- Trial name
- TESmTBI (NCT03244475)
- Testing
- TES
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sport Related Concussion
Salivary Biomarkers for Concussion
Concussion (CC) (also called mild head trauma), which accounts for 85% of all head injuries, is very common in professional and amateur athletes.
- Trial name
- SportCo (NCT06149351)
- Testing
- Bio-fluid analysis for the implementation of a diagnostic test for sport related concussion
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sys2Diag
Concussion, Headache
Sphenopalatine Ganglion Block for Headache After Concussion
This clinical trial will enroll participants to evaluate the effects of SPG block on post-traumatic headache. The study hypothesizes that patients that receive a SPG block with lidocaine vs.
- Trial name
- NCT04650282
- Testing
- Lidocaine in SphenoCath device, Saline Solution in SphenoCath device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Brain Injury Traumatic Mild, Post-traumatic Stress Disorder
Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury
This study is testing the usefulness of two types of Brain Health \& Wellness classes for Veterans with a history of concussion to improve mental health.
- Trial name
- NCT06150196
- Testing
- Mindfulness-based Stress Reduction class, Brain Health Education class
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- East Bay Institute for Research and Education
Mild Traumatic Brain Injury, Concussion
Effect of Early Rest on Recovery From Pediatric Concussion
The purpose of this study is to find out if strict rest for 5 days helps children get better after concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post-concussive Syndrome
- Trial name
- NCT01101724
- Testing
- Mandated Rest, Intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical College of Wisconsin
Concussion Mild
Yoga and Female Concussion
Most research on the impact of mild Traumatic Brain Injury/Concussions have been deficit-based and focused on the impairments induced by the injury. Research shows that trauma doesn't always have negative effects.
- Trial name
- NCT07170488
- Testing
- Yoga, Yoga for wait list control
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pittsburgh
Post Concussive Syndrome
An fMRI Study of Attention and Effort After Concussion
Approximately 1.1 million people a year suffer a mild traumatic brain injury (MTBI), or concussion, in the United States. Although most MTBI patients fully recover, as many as 28% have physical, cognitive, and/or emotional…
- Trial name
- NCT00653029
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Traumatic Brain Injury, Brain Concussion
Comparison of the DANA to the ANAM in the Evaluation of Cognitive Changes After Concussion
The Defense Automated Neurobehavioral Assessment (DANA) was recently developed as a durable, portable, and "field-hardened" NeuroCognitive Assessment Tool.
- Trial name
- NCT01728142
- Testing
- DANA Brief, ANAM
- Where
- Afghanistan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Brain Concussion, Mild Traumatic Brain Injury
The Role of Mechanical Diagnosis and Therapy in the Management of Concussion
The purpose of this study is to examine the role of a Mechanical Diagnosis and Therapy (MDT) examination in identifying participants diagnosed with concussion who display a directional preference compared to who don't display a…
- Trial name
- NCT05859815
- Testing
- Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- State University of New York at Buffalo
Traumatic Brain Injury
Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury
Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury.
- Trial name
- NCT02229643
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai 6th People's Hospital
Post Traumatic Stress Disorder, Mild Traumatic Brain Injury, Concussion
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with concurrent mild TBI and PTSD.
- Trial name
- NCT01921179
- Testing
- GOALS (Goal-Oriented Attentional Regulation), EDU (Brain Health Education)
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury - UCSF
This hypothesis-generating feasibility study compares mTBI Patients and Controls using advanced MRI Applications.
- Trial name
- TBI-2 (NCT02141360)
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- GE Healthcare
Brain Concussion
ImPACT Online Clinical Study
The researchers want to find out more about a standalone software application, ImPACT Online and how it relates to other commonly used tests of memory, attention and reaction time.
- Trial name
- NCT02701842
- Testing
- ImPACT Online/Paper Pencil Tests, ImPACT Online
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Mild Traumatic Brain Injury (mTBI)
Symptom-Targeted Approach to Rehabilitation for Concussion (STAR-C)
Purpose: Investigators propose a three-arm RCT across two military treatment facilities:1) in-person STAR-C, 2) telehealth STAR-C, and 3) no treatment control.
- Trial name
- STAR-C (NCT06855186)
- Testing
- Symptom-Targeted Approach to Rehabilitation for Concussion
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Concussion, Brain, Sports-related Concussion
Ecological Test Standardization for Concussion Assessment in Football Players
Concussion is a major concern in the sports world. It represents an immediate and transient alteration of neurological functions due to a direct or indirect trauma, with or without loss of consciousness.
- Conditions
- Concussion, Brain, Sports-related Concussion, Football Players, Traumatic Brain Injury, Mild
- Trial name
- COMOFOOT (NCT07431320)
- Testing
- Ecological Dual-Task Cognitive Assessment, Visuospatial Working Memory Ecological Test
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape
Transcranial Magnetic Stimulation, Functional Near-Infrared Spectroscopy
Treatment of Post-concussion Syndrome With TMS: Using FNIRS as a Biomarker of Response
Every year, approximately 2 million people in the United States and 280,000 in Canada experience a mild traumatic brain injury/concussion.
- Conditions
- Transcranial Magnetic Stimulation, Functional Near-Infrared Spectroscopy, Post-Concussion Syndrome, Concussion
- Trial name
- NCT04568369
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Calgary
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Post-Concussion Syndrome, Post-Traumatic Headache
Digital Solutions for Concussion
The objective of this study is to develop new digital solutions for patients with prolonged postconcussion symptoms, and investigate its usability, feasibility, and safety.
- Trial name
- DiSCo (NCT05635656)
- Testing
- Digital symptom mapping and biofeedback treatment
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- St. Olavs Hospital
Cerebral Concussion, Brain Concussion
Concussion Assessments in Football
Diagnosing and determining the severity of a sports-related concussion immediately on- or off-field is challenging, especially because clinical signs can evolve minutes to hours after the mechanism of injury.
- Conditions
- Cerebral Concussion, Brain Concussion, Post-Concussion Symptoms, TBI (Traumatic Brain Injury)
- Trial name
- NCT05713942
- Testing
- The Sport Concussion Assessment Tool 5th Edition (SCAT5), The Immediate Post-Concussion Assessment and Cognitive Testing tool version 4 (ImPACT)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Federation Internationale de Football Association