Clinical trials: Closed Head Trauma
Brain Injuries, Traumatic
Testing Mild Traumatic Brain Injury (mTBI) in Diverse Athletic Groups
Study will test the use of a short virtual reality driven goggle test as a means of detecting mTBI in a diverse group of athletes
- Trial name
- NCT03515967
- Testing
- I-PAS Goggles
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Concussion; Syndrome
Correlation Between Changes in Measures of the Visual System and Changes in Concussion-associated Symptoms
Sports-related concussion affect 1.6 to 3.8 million people each year in the United States. Despite increased media attention and awareness campaigns, the exact number is difficult to determine due to underreporting by athletes.
- Trial name
- NCT03259178
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McGill University
Head Injury, Minor, Concussion, Mild
Heading in Football: Impact on Neural Blood Biomarkers
The goal of this observational study is to evaluate the safety of heading in football. We will study the release of biomarkers in blood that reflect microscopic neural damage.
- Conditions
- Head Injury, Minor, Concussion, Mild, CTE - Chronic Traumatic Encephalopathy, Neurodegeneration
- Trial name
- HEADLINE (NCT06147596)
- Testing
- Head impact exposure
- Where
- Netherlands
- Volunteers
- 335 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Traumatic Brain Injury
Interacting Together Everyday: Recovery After Childhood Traumatic Brain Injury (TBI) "I-InTERACT
The purpose of this study is to test an on-line intervention for families of young children who have experienced moderate or severe traumatic brain injury (TBI).
- Trial name
- I-InTERACT (NCT01056146)
- Testing
- Internet-based Interacting Together Everyday: Recovery After Childhood TBI, Internet Resources Comparison
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Mild Traumatic Brain Injury
Photobiomodulation for Concussions: the Use of the ImPACT® Test as an Assessment Tool
Brain photobiomodulation (PBM) therapy is an innovative modality for the stimulation of neural activity in order to improve brain function and is currently under investigation as a treatment for several diverse neurological…
- Trial name
- NCT04823507
- Testing
- BIOFLEX DUO+
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Meditech Rehabilitation Centre
Growth Hormone Deficiency, Traumatic Brain Injury
Charactertizing Growth Hormone Deficiency in Traumatic Brain Injury
The goal of this observational study is to characterize the impact of growth hormone deficiency (GHD) on quality of life, symptom burden, and sleep in adults with traumatic brain injury (TBI), and to evaluate whether these…
- Trial name
- NCT07795736
- Testing
- Not applicable (observational study)
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Post-Traumatic Headache, PTSD
Art Therapy QEEG Study for Service Members with a Traumatic Brain Injury and Posttraumatic Stress Symptoms
Service members and/or recently separated veterans with post traumatic stress symptoms and mild traumatic brain injury may participate in 8 sessions including 2 sessions including interviews and questionnaires as well as 6…
- Conditions
- Post-Traumatic Headache, PTSD, TBI, TBI (Traumatic Brain Injury)
- Trial name
- ArtTherapy (NCT04776304)
- Testing
- Art Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Walter Reed National Military Medical Center
Concussion
Concussion Texting Study
This will be a prospective study of the implementation of a real-time assessment and intervention of a text messaging tool in mild traumatic brain injury (mTBI) patients post-discharge from the emergency department.
- Trial name
- texting (NCT03099733)
- Testing
- text message
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Mild Traumatic Brain Injury, Suicidal Ideation
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicidal Ideation, Impulsivity
- Trial name
- NCT05647044
- Testing
- intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among teens who have had a traumatic brain injury…
- Trial name
- RRTC--TOPS (NCT01042899)
- Testing
- Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
PostTraumatic Stress Disorder, Traumatic Brain Injury
Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder
The purpose of this study is to evaluate the safety and efficacy of individualized, Biometrics-guided Magnetic e-Resonance Therapy (MeRT) treatment of Post-Traumatic Stress Disorder
- Conditions
- PostTraumatic Stress Disorder, Traumatic Brain Injury, Postconcussive Symptoms
- Trial name
- MeRT-005-B (NCT02990793)
- Testing
- Active MeRT Treatment
- Where
- 8 sites in United States
- Volunteers
- 158 people
- Sponsor
- Wave Neuroscience
Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury
BCAAs in Concussion 3.0
This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion.
- Conditions
- Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury, Concussion, Brain, Concussion
- Trial name
- NCT07670195
- Testing
- BCAA
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Akiva Cohen
Brain Concussion, Brain Injuries
Screening Brain MRI in High School Football: Does the Guardian Cap Reduce the Risk of Traumatic Brain Injury
Screening Brain magnetic resonance imaging (MRI) with Fluid-attenuated Inversion Recovery (FLAIR) and Susceptibility Weighted Imaging (SWI) sequences will be performed pre and post season on high school football players.
- Conditions
- Brain Concussion, Brain Injuries, Diffuse Axonal Injury, Athletic Injuries
- Trial name
- NCT02757053
- Testing
- Guardian Cap
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mosaic Life Care
Healthy, CVA
Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.
DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.
- Conditions
- Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury)
- Trial name
- NCT04095377
- Testing
- No intervention, this is a retrospective study.
- Where
- Israel
- Volunteers
- 875 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Concussion, Mild
EFFECTS OF VESTIBULAR REHABILITATION THERAPY (VRT) ON BALANCE, SPEED AND AGILITY IN POST-CONCUSSION FOOTBALL PLAYERS
Traumatic brain injury (TBI) is one and utmost rampant attained neurological conditions which can happen in young adults. Vestibular Rehabilitation Therapy can help them improve their balance, speed and agility.
- Trial name
- NCT04487821
- Testing
- Cawthorne Cooksey Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Zohra Institute of Health Sciences
Brain Injuries, Traumatic, Concussion, Brain
Objective Brain Function Assessment of mTBI/Concussion in High School Athletes
This study (Part 2) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Concussion, Mild, Concussion, Intermediate
- Trial name
- AheadCAS-HS (NCT02661633)
- Testing
- BrainScope Ahead 200iD, Advanced MRI Neuroimaging
- Where
- 4 sites in United States
- Volunteers
- 177 people
- Sponsor
- BrainScope Company, Inc.
Traumatic Brain Injury
Magnetic Resonance Elastography in Patients With Acute Closed Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public health issue, and intracranial hypertension in the acute phase remains a critical scientific issue.
- Trial name
- NCT04361578
- Testing
- Magnetic resonance elastography
- Volunteers
- 43 people
- Sponsor
- Xiangya Hospital of Central South University