Clinical trials: Closed Loop
Pancreatectomy, Total Pancreatectomy
Hybrid Closed-Loop Insulin Delivery After Pancreatectomy
Individuals with diabetes secondary to pancreatectomy experience impaired quality of life, partly due to the challenges of managing highly variable blood glucose levels.
- Conditions
- Pancreatectomy, Total Pancreatectomy, Partial Pancreatectomy
- Trial name
- HCL PP (NCT07430293)
- Testing
- MiniMed 780 associated with Simplera
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Sud Francilien
Parkinson Disease
Closed Loop Programming Evaluation Using External Responses for Deep Brain Stimulation
The objective of this study is to evaluate the performance of novel DBS programming methods compared to traditional programming methods.
- Trial name
- CLOVER (NCT03037398)
- Testing
- Vercise Deep Brain Stimulation System
- Where
- 3 sites in Germany
- Volunteers
- 69 people
- Sponsor
- Boston Scientific Corporation
Diabetes Mellitus, Type 1
Automated Insulin Delivery for Type 1 Diabetes - Beyond Glucose Metrics
The goal of this clinical trial is to determine if transitioning to automated insulin delivery (AID) systems, can improve objectively measured sleep quality and quantity and alleviate cardiovascular risk factors in both children…
- Trial name
- AID-BEYOND (NCT06469593)
- Testing
- Automated insuling delivery system
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Steno Diabetes Center Copenhagen
Approach/Avoidance Behavior
Theta Phase-specific TMS to Modulate Prefrontal Activity
The purpose of this study is to evaluate the causal link between the phase of ongoing theta oscillations in the prefrontal cortex and approach/avoidance (Ap/Av) behavior in adults using theta phase-specific transcranial magnetic…
- Trial name
- NCT05416138
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes type1
T1D Closed-loop and Physical Activity
"Physical activity is recognized as beneficial for patients living with type 1 diabetes (T1DM), with a demonstrated effect not only on HbA1c control [1] but also on reducing the incidence of diabetes-related complications [2,3].
- Trial name
- NCT06460558
- Testing
- Type 1 diabetes with insulin infusion system
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Patients Undergoing Robotic Surgery
Quality of Recovery After Robotic Surgery
Robotic approach to laparoscopic surgery has greatly facilitated undertaking complex surgery inside the abdominal cavity with ease.
- Trial name
- NCT03659539
- Testing
- PROPOFOL, Desflurane
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Nitin Sethi, DNB
Diabetes Mellitus, Type 1
Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy (France)
An unblinded, randomized, cross-over design with each patient participating in two 40-hour outpatient admissions: (a) Experimental involving automated Control-to-Range (CTR) and (b) Control using Continuous Glucose Monitor…
- Trial name
- NCT01742741
- Testing
- Diabetes Assistant (DiAs)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Diabetes Type 2
Evaluation of a Closed-loop Insulin Delivery System at Home With Tailored Home Care Services in Poorly Controlled Type 2 Diabetes Patients (T2D)
Closed-loop insulin delivery system has the potential to improve the condition of many poorly controlled insulin-treated Type 2 Diabetes (T2D) patients.
- Trial name
- CLOSEAP+ (NCT04233229)
- Testing
- t:slim X2 with Control-IQ, home healthcare services, usual care for daily insulin treatment
- Where
- 10 sites in France
- Volunteers
- 43 people
- Sponsor
- Air Liquide Santé International
Parkinson Disease
Scalar Closed Loop Intraoperative Study
The purpose of this study is to measure neural activity during deep brain stimulation (DBS). There are two types of neural activity that we will record from DBS electrodes during this study: DBS local evoked potentials (DLEPs)…
- Trial name
- NCT03270657
- Testing
- IPG; RC+S
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dennis Turner, M.D.
Diabetes Mellitus, Type 1
An Outpatient Study of Automated Blood Glucose Control With an Insulin-Only Bionic Pancreas
This is an open-label, non-randomized, pilot study to determine the safety and feasibility of the insulin-only bionic pancreas.
- Trial name
- NCT02536950
- Testing
- Fixed set point, Variable set point
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Bruce A. Buckingham
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Closed-loop syncHronization vErsuS convenTional Synchronization in sPontaneously Breathing Adult Nonivasive ventilationPatients
The study is a multicentric prospective randomised cross-over study. It evaluates the compatibility of patients with the device without altering the routine treatment applied.
- Conditions
- Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Chronic Respiratory Failure
- Trial name
- CHESTSPAN (NCT06357780)
- Testing
- close-loop synchronization controller with spontaneous mode, Conventional
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Anesthesia, Closed Loop Anesthesia Delivery System (CLADS)
Effect of Yoga on Anesthesia Management
TITLE: EFFECT OF SHORT-TERM PRANAYAMA ON ANAESTHESIA MANAGEMENT IN PATIENTS UNDERGOING CARDIAC SURGERY Primary aim: To evaluate the effect of pre-operative short term pranayama yoga on stress-induced hemodynamic (HR, MAP) changes…
- Trial name
- yoga (NCT03127891)
- Testing
- pranayama yoga, control group
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Diabetes Mellitus, Type 1
The Impact of a Moderate Carbohydrate Diet in Children With Type 1 Diabetes on Hybrid Closed-loop Therapy
In the past, carbohydrate restriction was indicated as a treatment for people with type 1 diabetes when exogenous insulin was not available.
- Trial name
- COMBINE1 (NCT06567158)
- Testing
- Moderate carbohydrate diet, Traditional diet
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus, Type 1
SAFE-AP: Automatic Control of Blood Glucose Under Announced and Unannounced Exercise
Achieving near-normoglycemia has been established as the main objective for most patients with diabetes. Despite growing evidence about the health benefits of regular exercise in diabetes, exercise-associated glycemic imbalance…
- Trial name
- SAFE-AP3 (NCT03577158)
- Testing
- Closed-loop controller with exercise mitigation module, Closed-loop controller without exercise mitigation module, Open-loop insulin infusion system
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Clinic of Barcelona
Anesthesia
Comparison of TIVA by Closed Loop Anaesthesia Delivery System Versus Target Controlled Infusion Device
Total intravenous anaesthesia (TIVA) is now being adopted as a preferred technique for providing GA because of its various inherent advantages like reduced PONV incidence, improved quality of recovery post GA, anti-inflammatory…
- Trial name
- NCT04731480
- Testing
- Propofol
- Where
- 2 sites in India
- Volunteers
- 160 people
- Sponsor
- Sir Ganga Ram Hospital
Depression
Brain-oscillation Synchronised Stimulation of the Prefrontal Cortex
Combining TMS and EEG, this study investigates a personalized therapeutic non-invasive brain stimulation protocol in patients with major depression, whereby the timing of the TMS pulses is synchronized with the instantaneous…
- Trial name
- BOSSFRONT (NCT02920840)
- Testing
- Intermittent theta-burst stimulation, Negative-peak-triggered-TMS, Open-loop replay TMS
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- University Hospital Tuebingen
Type 1 Diabetes, Insulin Therapy
Study on the Use of the Insulin Pump Tandem X:2 With Control IQ Algorithm - Update
The aim of this observational clinical trial is to obtain data on the safety, efficacy and satisfaction of the Tandem T:Slim X:2 Pump System in patients with type 1 diabetes.
- Trial name
- UNIQUE (NCT05118945)
- Testing
- Insulin pump Tandem: t:slim X2
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetes Mellitus, Type 1
Controlled Insulin Delivery: Combining Technology With Treatment
Hypothesis: Closed-loop control systems for an artificial pancreas using multi-parametric model predictive control can be developed and evaluated safely in patients with Type 1 Diabetes Mellitus (T1DM) to control blood glucose…
- Trial name
- NCT01484457
- Testing
- Closed-loop session
- Where
- 2 sites in United States, Israel
- Volunteers
- 19 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846857
- Testing
- 15-week intervention with sensor-augmented pump, 15-week intervention with single-hormone closed-loop, 15-week intervention with dual-hormone closed-loop
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus, Type 1, Diabetes Complications
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts.
- Trial name
- NCT06236607
- Testing
- Device specific training, Study clinician/educator visit
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Boston Medical Center