Clinical trials: Closed-Loop
Brain Injuries
Efficiency of Coupling Targeted Temperature Management to Brain Temperature in Severe Brain Injury
In severe brain-injured patients, it is recommended to strictly control the fever in order to limit brain damage (objective of neuroprotection) via the targeted temperature management (TTM).
- Trial name
- BRAINTTM (NCT03967626)
- Testing
- external cooling with the xxxxx device
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Type 1 Diabetes, Pregnancy, High Risk
Commercial or Open Source Closed Loop Impact on Pregnancy Study
The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems.
- Conditions
- Type 1 Diabetes, Pregnancy, High Risk, Insulin Dependent Diabetes, Pregnancy Related
- Trial name
- COSCLIP (NCT06654713)
- Testing
- Commercial AID system, Open source AID system
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Francisco
Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects…
- Trial name
- CL-tACS RCT (NCT06874374)
- Testing
- Closed-loop tACS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pulvinar Neuro, LLC
Type 1 Diabetes
Assessing the Safety, Performance, and User Experience of the Tandem Mobi Automated Insulin Delivery System Among Young Competitive Athletes in Real-world Settings.
A single arm, interventional study with 12 weeks study phase preceded by a 2-week run in phase, aiming to evaluate the effectiveness and applicability of the Tandem Mobi automated insulin delivery system (Tandem Mobi Pump System)…
- Trial name
- Captain MOBI (NCT06979635)
- Testing
- Tandem Mobi Hybrid Closed Loop (HCL) pump
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes Mellitus
The Artificial Pancreas in Very Young Children With T1D
The suggested clinical trial is part of the KidsAP project funded by the European Commission's Horizon 2020 Framework Programme and JDRF.
- Trial name
- KidsAP02 (NCT03784027)
- Testing
- CamAPS FX, Sensor augmented therapy
- Where
- 8 sites in Austria, Germany and 2 more
- Volunteers
- 81 people
- Sponsor
- University of Cambridge
Acute Cholecystitis, Chronic Cholecystitis
Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor
The purpose of this study is to compare a closed-loop intravenous anesthetic using Bispectral Index as a feedback loop and a controller based on reinforcement learning to titrate dose and intravenous anesthetic that is manually…
- Trial name
- NCT01942356
- Testing
- TIVA - Hypotension, TIVA - Hypertension, TIVA - Bradycardia
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Biomedical Technology, Type 1 Diabetes
Analysis of Glycemic Control in Type 1 Diabetes Patients Using Hybrid Closed Loop Insulin Pump Therapy (Medtronic 670G)
Observational study of patients at Boston Childrens Hospital with type 1 diabetes (T1D) who elected to treat their diabetes with the Medtronic 670 G hybrid closed loop insulin pump.
- Trial name
- NCT04051632
- Testing
- Medtronic 670G insulin pump
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Adults With Type 1 Diabetes
Postprandial meal glucose control with closed-loop systems (CLS) still needs some improvements. In the postprandial period, sensor delay in detecting blood glucose rise after a meal together with delays in insulin absorption…
- Trial name
- NCT02416765
- Testing
- 15-hour intervention, Insulin (Lispro, Aspart or guilisine), Glucagon (Eli Lilly)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Anesthesia
The Effect on the Older's Cognition of Dual-loop Target Controlled Infusion Guided by Narcotrend Index
To investigate the effect on older's cognition of the application of closed target-controlled infusion(TCI) of propofol and remifentanil guided by Narcotrend index .
- Trial name
- POCD;TCI (NCT03010098)
- Testing
- Dual-Loop TCI, Open-Loop TCI
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Major Depressive Disorder, Healthy
Sleep Modulation to Treat Depression
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need…
- Trial name
- NCT06443216
- Testing
- Auditory closed-loop stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Christoph Nissen
T2DM Patients With Traumatic Brain Injury
Hybrid Closed-Loop System in Neurosurgical Perioperative Hyperglycemia: An Open RCT
In this study, we plan to use an open-source hybrid closed-loop artificial pancreas system and a combination of a traditional insulin pump and continuous glucose monitoring (CGM) respectively to conduct short-term intensive…
- Trial name
- NCT06909071
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanxi Bethune Hospital
Diabetes Mellitus, Type 1
Effect of Advanced Hybrid Closed Loop System on Adjunctive Continuous Glucose Monitoring Metrics
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by pancreatic beta cells destruction, resulting in insulin secretion deficit (1).
- Trial name
- TiTR_GR1DM (NCT06334484)
- Testing
- Advanced hybrid closed loop systems
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anesthesia
Influence of Dexmedetomidine on a Closed-Loop Anesthesia System
The main objective if to evaluate the sparing effect of dexmedetomidine on the doses of propofol and remifentanil.
- Trial name
- NCT00921284
- Testing
- NaCl 9/00, dexmedetomidine
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Hopital Foch
Type 1 Diabetes
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes.
- Trial name
- WBH002 (NCT05653518)
- Testing
- Tandem t:slim X2 with Control-IQ Technology, Sensor augmented pump (SAP) therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Extended Bolus for Meals in a Closed-loop System
This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system.
- Trial name
- NCT05454891
- Testing
- Tandem t:slim X2 insulin pump: Extended bolus of insulin then standard bolus of insulin, Tandem t:slim X2 insulin pump: Standard bolus of insulin then extended bolus of insulin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Type 1 Diabetes
DiaCon Overnight Closed-Loop Glucose Control Study
The objective of this in-clinic study is to test our closed-loop glucose control system in patients with type 1 diabetes.
- Trial name
- DiaCon2 (NCT01444443)
- Testing
- Closed-loop control, Open-loop control
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Type 1
The Impact of a Moderate Carbohydrate Diet in Children With Type 1 Diabetes on Hybrid Closed-loop Therapy
In the past, carbohydrate restriction was indicated as a treatment for people with type 1 diabetes when exogenous insulin was not available.
- Trial name
- COMBINE1 (NCT06567158)
- Testing
- Moderate carbohydrate diet, Traditional diet
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 1 Diabetes
Preventing Hypoglycemia During Exercise With Proactive Snacking on Closed Loop
This study is designed to look at how snacking during exercise may help prevent low blood sugars while subjects are on the "closed loop artificial pancreas." This system uses a continuous glucose sensor, an insulin pump, and a…
- Trial name
- NCT02135068
- Testing
- Medtronic MiniMed Closed Loop (CL) System, Snacking
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Chronic Pancreatitis, Diabetes Mellitus
Closed Loop Insulin Pump Therapy After Islet Auto-Transplantation
The purpose of this study is to determine the effectiveness of closed loop insulin pump therapy to control blood sugar following total pancreatectomy and islet auto-transplantation (TPIAT).
- Trial name
- NCT01945138
- Testing
- Closed Loop Insulin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota
Syncope, Vasovagal, Neurally-Mediated
The Tilt Test-Induced REsponse in Closed-loop Stimulation (TIRECS) Study
Multicentre, prospective, double blinded, randomized study designed as an intrapatient comparison to evaluate the effects of the Biotronik Closed-loop Stimulation algorithm on prevalence and timing of haemodynamic variations and…
- Trial name
- TIRECS (NCT02573649)
- Testing
- Closed-loop Stimulation on first, Closed-loop Stimulation off first
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico