Clinical trials: Closed-Loop
Type1 Diabetes Mellitus
Adolescence and Diabetes:Can an Automated Closed Loop System Improve Control ?
This study evaluates the use of the FD2 automated closed loop insulin administration in Adolescents with a poor metabolic control .
- Trial name
- SPIDIMAN2 (NCT03300934)
- Testing
- closed loop glucose control system
- Where
- Luxembourg
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier du Luxembourg
Anesthesia
The Effect on the Older's Cognition of Dual-loop Target Controlled Infusion Guided by Narcotrend Index
To investigate the effect on older's cognition of the application of closed target-controlled infusion(TCI) of propofol and remifentanil guided by Narcotrend index .
- Trial name
- POCD;TCI (NCT03010098)
- Testing
- Dual-Loop TCI, Open-Loop TCI
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Diabete Type 1
Eating Disturbances in Patients With Type 1 Diabetes Initiating Insulin Therapy
The prevalence of eating disorders is particularly high among people with type 1 diabetes (T1D). These abnormalities, such as "diabulimia," are frequently responsible for poor insulin therapy management and, consequently, chronic…
- Trial name
- CALI-BF (NCT07151924)
- Testing
- Questionnaires answers, Biological assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Heart Failure, ICD
Comparing Rate Response With CLS Versus Accelerometer ICD Settings in Heart Failure Patients With BIOTRONIK CRT-Ds
Dr. Jonathan Hsu and Dr. Eric Adler are conducting a research study to find out more about how implantable cardiac defibrillator (ICD) settings can be adjusted to improve patient cardiovascular health and quality of life.
- Conditions
- Heart Failure, ICD, Chronotropic Incompetence
- Trial name
- CLASS (NCT02693262)
- Testing
- CLS Mode on Biotronik CRT-D, Accelerometer Mode on Biotronik CRT-D
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Anesthesia
Automatic Control of Total Intravenous Anesthesia (ACTIVA)
This study concerns the clinical evaluation of a closed loop control system for the automatic administration of anesthetic drugs in TIVA (Total Intra Venous Anesthesia).
- Trial name
- ACTIVA (NCT04432974)
- Testing
- Automatic closed-loop anesthesia
- Where
- Italy
- Volunteers
- 139 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Type 1 Diabetes
SGLT2 Inhibitor Adjunctive Therapy to Closed Loop Control in Type 1 Diabetes Mellitus
The primary purpose of this study is to evaluate the safety and efficacy of combining SGLT2 inhibitors with closed loop control (CLC).
- Trial name
- CiQ-SGLT2 (NCT04201496)
- Testing
- Empagliflozin + Control-IQ x 4 wks then Basal-IQ x 2 wks, Empagliflozin + Basal-IQ x 2 wks then Control-IQ x 4 wks, No Empagliflozin + Control-IQ x 4 wks then Basal-IQ x 2 wks
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ananda Basu, MD
Minimally Conscious State
Closed-loop tDCS in Patients in Minimally Conscious State
This research will test a closed-loop system using EEG-arousal measures (spectral entropy) to define the best moment of the day for application of transcranial direct current stimulation (tDCS) in patients in MCS This study aims…
- Trial name
- NCT03810079
- Testing
- Anodal transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University of Liege
Covid19, Hypoxemic Respiratory Failure
Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen.
- Conditions
- Covid19, Hypoxemic Respiratory Failure, Hypoxemia
- Trial name
- O2matic-COVI (NCT04565106)
- Testing
- Closed-loop control of oxygen supplementation by O2matic
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Surgery
Crystalloids or Colloids for Goal-directed Fluid Therapy With Closed-loop Assistance in Major Surgery
Study goal: This study will examine whether there is a significant difference in postoperative outcomes between GDFT using a colloid solution versus a crystalloid solution.
- Trial name
- NCT02312999
- Testing
- Plasmalyte, Volulyte
- Where
- 2 sites in Belgium
- Volunteers
- 160 people
- Sponsor
- Brugmann University Hospital
Type 1 Diabetes, Obesity
ADJUnct Semaglutide Treatment in Type 1 Diabetes
The purpose of this study is to assess the use of once weekly semaglutide injection in inadequately controlled obese adults with type 1 diabetes (T1D) using FDA-approved hybrid closed-loop therapies.
- Trial name
- ADJUST-T1D (NCT05537233)
- Testing
- Semaglutide
- Where
- 4 sites in United States
- Volunteers
- 115 people
- Sponsor
- Viral N. Shah
Diabetes Mellitus
Automated Insulin Delivery for INpatients With DysGlycemia (AIDING) Feasibility
This single-arm stepwise feasibility study will test initial deployment of hybrid closed-loop (HCL) automated insulin delivery (AID) using the Omnipod 5/Horizon HCL system with remote monitoring and device operation capabilities…
- Trial name
- NCT04714216
- Testing
- The Omnipod 5/Horizon HCL system
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Emory University