Clinical trials: Closed-loop Brain Stimulation
Parkinson Disease
Deep Neural Network Approaches for Closed-Loop Deep Brain Stimulation
In this research study the researchers want to learn more about brain activity related to speech perception and production in patients with Parkinson's Disease who are undergoing deep brain stimulation (DBS).
- Trial name
- NCT04277689
- Testing
- Brain signal data collection
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Parkinson Disease
Safety and Efficacy of Adaptive DBS Vs Conventional DBS in Patients With Parkinson's Disease
This is an exploratory study to preliminary assess safety and efficacy of an adaptive Deep Brain Stimulation (DBS) closed-loop method in patients with PD.
- Trial name
- NCT03422757
- Testing
- adaptive Deep Brain Stimulation, conventional Deep Brain Stimulation
- Where
- 4 sites in Italy
- Volunteers
- 6 people
- Sponsor
- Newronika
Essential Tremor
Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives
The objective of this study is to characterize through spectral analysis intra-thalamic local field potentials (LFPs) recorded through implanted DBS leads during periods with and without tremor in patients suffering from severe…
- Trial name
- VIM-CLT (NCT02264925)
- Testing
- Deep Brain Stimulation with Medtronic Activa PC+S systems
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bordeaux
Advanced Parkinson's Disease
Clinical Study for Adaptive Deep Brain Stimulation (aDBS)Controlled by Intracerebral Activity in Parkinson's Disease
Despite its therapeutic effectiveness in Parkinson's disease (PD) the current deep brain stimulation (DBS) strategy could achieve an even better clinical result by adapting to patient's condition.
- Trial name
- ADBS (NCT02154724)
- Testing
- aDBS, DBS
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Epilepsy
Stimulation of Sleep in Patients With Epilepsy
Sleep slow waves (SSW) and the pathophysiological mechanisms of spike generation in patients with epilepsy are tightly linked. SSW are cortically generated oscillations (~1 Hz) alternating between a hyperpolarized down-state…
- Trial name
- NCT04716673
- Testing
- Down-phase targeted auditory stimulation
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Parkinson Disease
Closed Loop DBS Implanted RC+S Study
This study involves patients who are already planning to have deep brain stimulation (DBS) surgery to treat the symptoms of severe Parkinson's Disease (PD). The study has two goals: 1.
- Trial name
- NCT03815656
- Testing
- STN alone, GPi alone, STN + GPi
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Dennis Turner, M.D.
Novel Method for Transcranial Brain Stimulation
Phase Locked TRanscranial Electrical EXcitation
Transcranial current stimulation (tCS) has been extensively studied due to its potential of selectively stimulate brain regions in a non-invasive way.
- Trial name
- T-REEX (NCT05847829)
- Testing
- T-REEX algorithm
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stichting IMEC-NL
Stroke, Upper Extremity Parasis
Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase…
- Trial name
- TMS (NCT06849505)
- Testing
- online rTMS, offline rTMS
- Where
- China
- Volunteers
- 15 people
- Sponsor
- First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
Minimally Conscious State
Closed-loop tDCS in Patients in Minimally Conscious State
This research will test a closed-loop system using EEG-arousal measures (spectral entropy) to define the best moment of the day for application of transcranial direct current stimulation (tDCS) in patients in MCS This study aims…
- Trial name
- NCT03810079
- Testing
- Anodal transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University of Liege
Non-invasive Brain Stimulation, Methodologic Study
Closed-loop Non-invasive Brain Stiumlation
Transcranial magnetic stimulation (TMS) is a widely used tool for exploring brain function in humans (Siebner et al. et al., 2022), which has led to new therapeutics for various psychiatric and neurological disorders (Lefaucheur…
- Trial name
- CLOSEDLOOP (NCT06600217)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson's Disease (PD)
Closed-Loop Therapeutic Refinement Using Local Field Potentials in Parkinson's Disease
This multi-center pilot study compares conventional DBS (cDBS) and adaptive DBS (aDBS) in Parkinson's disease patients using the Medtronic Percept™ system.
- Trial name
- CTRL-PD (NCT07105280)
- Testing
- Optimized conventional DBS, Optimized adaptive DBS
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- HagaZiekenhuis
Parkinson Disease
Closed-loop DBS in Parkinson's Disease
Closed-loop DBS is an emerging neuromodulation pattern in Parkinson's disease with dyanmic adjustment of stimulation parameters to patients' disease fluctuations and state of activity.
- Trial name
- NCT06012461
- Testing
- Closed-loop DBS stimulation for 24 hours, Open-loop DBS stimulation for 24 hours, Closed-loop DBS stimulation for 72 hours
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Tsinghua University
Hypertension, Blood Pressure
HIRREM for Stage 1 Primary Hypertension
The purpose of this study is to determine that effects of an intervention called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), on Stage 1 Primary Hypertension (systolic BP 130-139, and/or…
- Conditions
- Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- HIRREM (NCT03479697)
- Testing
- HIRREM, Continued Current Care
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Parkinson Disease
Studying Movement Control in Parkinson's Disease Using Closed Loop Deep Brain Stimulation
Parkinson's disease is a common, disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory.
- Trial name
- NCT02585154
- Testing
- Deep Brain Stimulation applied through custom built external stimulator (Little et al., 2013, 2015), closed-loop Deep Brain Stimulation applied through custom built external stimulator (Little et al., 2013, 2015), Deep Brain Stimulation off
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Major Depression, Sleep
Sleep TMS for Depression
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
- Trial name
- NCT06824415
- Testing
- TMS
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Parkinson Disease
Closed Loop Programming Evaluation Using External Responses for Deep Brain Stimulation
The objective of this study is to evaluate the performance of novel DBS programming methods compared to traditional programming methods.
- Trial name
- CLOVER (NCT03037398)
- Testing
- Vercise Deep Brain Stimulation System
- Where
- 3 sites in Germany
- Volunteers
- 69 people
- Sponsor
- Boston Scientific Corporation
Insomnia, Sleep Deprivation
Study of the Effects of HIRREM-SOP for Insomnia
Prior research studies have shown benefit for use of a technique called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®), to reduce symptoms of moderate to severe insomnia.
- Trial name
- NCT03607994
- Testing
- HIRREM-SOP, NCC
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Upper Extremity Dysfunction After the Stroke
Individualized rTMS Synchronized Task Training for Closed-loop Neuromodulation of Post-stroke Motor Dysfunction
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase…
- Trial name
- rTMS (NCT07049211)
- Testing
- Individualized online stimulation, Non-individualized online stimulation
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Ruijin Hospital
PPA
Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia
This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with Primary Progressive Aphasia (PPA)…
- Trial name
- NCT07511179
- Testing
- Active tES, Cognitive Interventions
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Bipolar II Disorder, Bipolar II Disorder, Most Recent Episode Major Depressive
Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry.
- Trial name
- PReSiDio-BP (NCT07127913)
- Testing
- Device: Stimulation-ON, Device: Stimulation-OFF, Device: Stimulation -ON Active Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Andrew Krystal