Clinical trials: Clostridium, open to volunteers
Tetanus
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection
A Randomized, Double-blind, Controlled, Dose-escalation Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Intramuscular Injection of Recombinant Human Anti-tetanus…
- Trial name
- NCT07149454
- Testing
- Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection, Human Tetanus Immunoglobulin
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Lanzhou Institute of Biological Products Co., Ltd
Carpometacarpal Sprain, Thumb Sprain
Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis
The purpose of this clinical trial is to gather information on the safety and effectiveness of botulinum toxin injection (or Botox) in the treatment of thumb joint pain/arthritis.
- Conditions
- Carpometacarpal Sprain, Thumb Sprain, Clostridium; Botulinum
- Trial name
- NCT05990881
- Testing
- Botulinum toxin, Standard-of-care corticosteroid injections
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rhode Island Hospital
Tetanus, Manifest
Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus
Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.
- Trial name
- NCT07512167
- Testing
- Tetanus Severity Score (TSS), Philips Score, Dakar Score
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Ain Shams University
Pertussis (Whooping Cough), Diphtheria
A Phase II Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents)
the immunogenicity and safety of different dosages of adsorbed acellular pertussis (two-component) diphtheria-tetanus combined vaccine
- Conditions
- Pertussis (Whooping Cough), Diphtheria, Tetanus
- Trial name
- NCT07894055
- Testing
- Tdap vaccine
- Where
- China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Changchun BCHT Biotechnology Co.
Fecal Microbiota Transplantation, Clostridium Difficile Infection
Fecal Microbiota Transplant National Registry
A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety and effectiveness
- Conditions
- Fecal Microbiota Transplantation, Clostridium Difficile Infection, Gut Microbiome
- Trial name
- FMT (NCT03325855)
- Testing
- None - Observational
- Where
- 53 sites in United States, Canada
- Volunteers
- 4,000 people
- Sponsor
- American Gastroenterological Association
Active C. Difficile Colitis
Defined Fecal Microbiota Transplantation for Clostridium Difficile Diarrhea
The study is on indefinite HOLD due to the loss of funding that occurred during the pandemic emergency. Subsequently, a key collaborator left our institution, and as a near-term result, the protocol awaits reactivation.
- Trial name
- NCT01868373
- Testing
- Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Clostridioides Difficile Infection
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody
The purpose of this study is to evaluate the efficacy and safety of AZD5148 for prevention of recurrence of Clostridioides difficile infection in Individuals 18 years of age and above.
- Trial name
- PRISM (NCT07285213)
- Testing
- AZD5148
- Where
- 117 sites in United States, Australia and 12 more
- Volunteers
- 230 people
- Sponsor
- AstraZeneca
Clostridioides Difficile Infection
Prevention of Recurrence of Clostridioides Difficile Colitis With Ursodeoxycholic Acid (UCDA) as a Supplement to Standard Therapy
The goal of this clinical trial is to determine whether Ursodeoxycholic Acid (UDCA) can help prevent recurrence of Clostridioides difficile (C. diff) colitis when used along with standard antibiotic treatment. C.
- Trial name
- PREVENT (NCT06884748)
- Testing
- Ursodiol 500 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Clostridioides Difficile Infection Recurrence, FMT
FMT Capsules for rCDI
Double blind RCT study of tretment of recurrent Clostridioides difficile infection by FMT capsules.
- Trial name
- FMT CAP CDI (NCT07458984)
- Testing
- Healthy donor stool
- Where
- Finland
- Volunteers
- 76 people
- Sponsor
- Helsinki University Central Hospital
Clostridioides Difficile Infection
Washed Microbiota Transplantation for Clostridioides Difficile Infection
This is a real-world study to explore the safety and the efficacy of washed microbiota transplantation （WMT） for patients with Clostridioides Difficile Infection （CDI）.
- Trial name
- NCT06106698
- Testing
- WMT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Probiotics, Cancer, Therapy-Related
The Effect of Survival, Response and Microbiota Change in Different Therapy Under Probiotic Supplement
Probiotics are a group of viable microorganisms including bacteria and yeasts that if consumed in sufficient amounts, may afford health benefits to the host.
- Trial name
- NCT06998823
- Testing
- Probiotics
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Irritable Bowel Syndrome, Diarrhea-Predominant (IBS-D), Recurrent Clostridioides Difficile Infection (rCDI)
A Flexible Clinical Trial to Test if Freeze-dried Fecal Microbiota Therapy Helps Treat Diarrhea-predominant Irritable Bowel Syndrome or Prevent Recurring C. Difficile Infections.
The goal of this clinical trial is to learn if oral lyophilized fecal microbiota therapy (ORAL-LYO-FMT) helps treat diarrhea-predominant irritable bowel syndrome (IBS-D) and prevent the recurrence of Clostridioides difficile…
- Conditions
- Irritable Bowel Syndrome, Diarrhea-Predominant (IBS-D), Recurrent Clostridioides Difficile Infection (rCDI), Fecal Microbiota Therapy (FMT), Irritable Bowel Syndrome (IBS)
- Trial name
- ORAL-LYO-FMT (NCT06948461)
- Testing
- ORAL-LYO-FMT
- Volunteers
- 63 people
- Sponsor
- PharmaPlanter Technologies Inc
Clostridioides Difficile Infection
Epidemiology of Clostridioides Difficile Infection (CDI) in Long-term Care Facilities, Assessment of Professional Practices Related to CDI Risk Prevention, and Strategies for Improving Care.
Clostridioides difficile infection (CDI) is the leading cause of infectious diarrhea among older adults. The epidemiology of community-acquired CDI, particularly among residents of long-term care facilities, remains poorly…
- Trial name
- EpiCE (NCT07920627)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Polio, Diphteria, Tetanus and Pertussis
Study of Concomitant Administration of the sIPV and DTaP or MMR
This study is a randomized, open-labeled phase IV clinical trial to evaluate the immunogenicity and safety of concomitant administration of sIPV and DTaP or MMR in infants aged 2 months.
- Conditions
- Polio, Diphteria, Tetanus and Pertussis, MMR Vaccine
- Trial name
- NCT06920069
- Testing
- sIPV, DTaP, bOPV 1,3
- Where
- 9 sites in China
- Volunteers
- 2,640 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Tetanus
A Registry： Siltartoxatug Injection for Tetanus Prophylaxis Following Injury
The injury and wound conditions of the enrolled patients will be documented. A follow-up at 90 days post-administration will determine the clinical outcome of tetanus prophylaxis, specifically whether tetanus occurred.
- Trial name
- NCT07107932
- Testing
- Siltartoxatug Injection (Brand name: Sintetol®)
- Where
- 4 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Zhuhai Trinomab Pharmaceutical Co., Ltd.
Clostridium Difficile Infection, Clostridioides Difficile Infection
Fecal Microbiota Transplantation (FMT) for Clostridium Difficile
Faecal microbiota transplantation (FMT) is used for Clostridioides difficile infection (CDI) as part of an quality improvement initiative and conducted within the framework of Center for Faecal Microbiota Transplantation at…
- Trial name
- CEFTA (NCT03712722)
- Testing
- Faecal microbiota transplantation (FMT)
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- University of Aarhus
Clostridioides Difficile Infection
Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain in Nephrology and Transplantation Department
The aim of this study was to analyze whether the use of the LP299v strain reduces the risk of Clostridium difficile infection (CDI) among patients receiving antibiotics and hospitalized in the nephrology and transplantation ward.
- Trial name
- NCT06859437
- Testing
- Prevention of C. difficile infections using LP299v strain LP299v
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC)
Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics
This is a large-scale observational study aiming to evaluate the long-term effectiveness and safety of Fecal Microbiota Transplantation (FMT).
- Conditions
- Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC), Crohn Disease (CD), Irritable Bowel Syndrome (IBS)
- Trial name
- NCT07261826
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Chen QiYi
Tetanus
TETANUS Antibody Detection in Saliva Study
This study aims to design, develop and optimise a non-invasive, saliva sample-based point-of-care lateral flow test for use in low and middle income settings that can return a qualitative result on whether an individual has or…
- Trial name
- TETANUS (NCT07446166)
- Testing
- Point of care, saliva-based lateral flow test, Blood based immunoassay
- Where
- Rwanda
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Tetanus
A Phase Ⅲ Clinical Study of SNA02-48 Injection
The primary objective of this clinical trial is to compare the efficacy and safety of SNA02-48 injection with Human Tetanus Immunoglobulin (HTIG) for tetanus prophylaxis.
- Trial name
- NCT07633119
- Testing
- SNA02-48, Human tetanus immunoglobulin (HTIG)
- Where
- 30 sites in China
- Volunteers
- 600 people
- Sponsor
- Sinovac Life Sciences Co., Ltd.