Clinical trials: Co-occurring Mental and Substance Use Disorders
Opioid Use Disorder, Mental Health Disorder
Supporting Treatment Access and Recovery in COD
This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team…
- Trial name
- STAR-COD (NCT05138614)
- Testing
- Medication for Opioid Use Disorder, MISSION Critical Time Intervention, MISSION Peer Support
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Massachusetts, Worcester
ADHD, Cannabis Use Disorder
Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder
The goal of this clinical trial is to look at how delayed-release, extended-release methylphenidate (Jornay PM), an FDA-approved medication for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), works to treat ADHD…
- Trial name
- NCT07838311
- Testing
- Delayed-release, extended-release methylphenidate
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Massachusetts General Hospital
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms
Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails
Opioid overdose is the leading cause of death among people recently released from incarceration. Recent evidence also shows a rise in stimulant use among justice-involved populations, as well as growing rates of concurrent opioid…
- Conditions
- Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder
- Trial name
- HOPE (NCT07490717)
- Testing
- Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
- Where
- 2 sites in United States
- Volunteers
- 338 people
- Sponsor
- University of Arkansas
Tuberculosis, Alcohol Use Disorders
Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, Russia
The primary goal of this study is to assess the effectiveness of two alcohol interventions administered singly or in combination as an integrated component of TB care provided to patients with co-occurring TB and AUDs in Tomsk…
- Trial name
- IMPACT (NCT00675961)
- Testing
- Brief Counseling Intervention (BCI), Naltrexone, BCI + Naltrexone
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Alcohol Abuse, Posttraumatic Stress Disorder
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder
The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency and symptoms of Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT01518972
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Substance Use Disorder, Mental Health Disorder
MISSION-CJ for Justice-Involved Homeless Veterans
The purpose of this study is to determine whether Maintaining Independence and Sobriety through Systems Integration, Outreach and Networking - Criminal Justice version (MISSION-CJ) is effective for reducing criminal recidivism…
- Conditions
- Substance Use Disorder, Mental Health Disorder, Homelessness
- Trial name
- MISSION-CJ (NCT04523337)
- Testing
- Maintaining Maintaining Independence and Sobriety through Systems Integration Outreach and Networking- Criminal Justice, Maintaining Maintaining Independence and Sobriety through Systems Integration Outreach and Networking Peer Support
- Where
- 3 sites in United States
- Volunteers
- 134 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Opioid Use Disorder
tAN for PTSD and OUD in Buprenorphine Therapy
The goal of this research study supported by the HEAL Initiative (https://heal.nih.gov) is to investigate the effects transcutaneous auricular neurostimulation (tAN), as delivered through the Sparrow Ascent device, on helping…
- Trial name
- NCT06130501
- Testing
- Sparrow Ascent tAN
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Substance Use Disorders, Bipolar Disorder
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
This study proposes to use quetiapine as an adjunct treatment to treatment as usual to improve both substance use disorder (SUD) and mood symptoms in youth with SUD and severe mood dysregulation (SMD).
- Conditions
- Substance Use Disorders, Bipolar Disorder, Mood Disorders
- Trial name
- NCT02845453
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Medical Center
PTSD, AUD
PTSD and Alcohol Couples Treatment for Veterans
Treatment of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) treatment for Veterans is challenging for Veterans.
- Trial name
- PACT-V (NCT07388654)
- Testing
- COPE + BFIT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder (AUD), PTSD
PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
This study is a phase 2 single-site, double-blind, placebo-controlled, randomized clinical trial with an open-label extension phase to examine the safety of psilocybin (25 mg) combined with psychological support (Psi-PS) for…
- Trial name
- Psi-PS (NCT06853912)
- Testing
- Psilocybin 25 mg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nathan Brashares Sackett
Mental Health Disorders, Substance Use Disorders
Supporting Treatment Access and Recovery Through Linkage and Support
This 3-year Hybrid Type 1 study will randomize 208 people with co-occurring substance use and mental health disorders (COD) referred from the Worcester Hub.
- Trial name
- STAR-LS (NCT05713695)
- Testing
- Full MISSION, Linkage Only Delivered by a Peer Specialist
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Massachusetts, Worcester
Posttraumatic Stress Disorder, Substance Use Disorders
Emotional Regulation in People With Co-occurring Posttraumatic Stress Disorder and Substance Use Disorder
The aim of this project is to look at emotional regulation in people with posttraumatic stress disorder (PTSD) and substance use disorder (SUD).
- Conditions
- Posttraumatic Stress Disorder, Substance Use Disorders, Emotional Regulation
- Trial name
- NCT05531318
- Testing
- Qualitative Interview
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- King's College London
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Integrated Treatment for Opioid Use Disorder and PTSD
This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone…
- Trial name
- NCT06641115
- Testing
- HOPE Therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Stress Disorders, Post-Traumatic, Opioid Use Disorder
MDMA for Co-occurring PTSD and OUD After Childbirth
This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD).
- Trial name
- NCT05219175
- Testing
- MDMA Assisted Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Chronic Pain, Opioid Use Disorder
Combined THC and CBD for OUD and Chronic Pain
The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid…
- Trial name
- NCT06544291
- Testing
- CBD 300mg, CBD 600mg
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Yale University
Mental Health Issue, Substance Use Disorders
Co-Active Therapeutic Theatre (Co-ATT) for Dual-Diagnosis Patients
Drama Therapy involves of the use of theatrical techniques (such as script development, acting exercises, improvisation, etc.) to help treat patients' mental illness and improve their functioning and overall sense of wellbeing.
- Trial name
- Co-ATT (NCT06187701)
- Testing
- Co-Active Therapeutic Theatre (Co-ATT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Medical Center
Stress Disorders, Post-Traumatic, Substance Use Disorders
Psychotherapy for PTSD Among Veterans Also Receiving Drug or Alcohol Treatment
Many people who have posttraumatic stress disorder (PTSD) also struggle with problematic alcohol or drug use (substance use disorders [SUD]). Patients with both conditions prefer PTSD be treated alongside SUD.
- Trial name
- COMPASS (NCT04581434)
- Testing
- Prolonged Exposure Therapy, Cognitive Processing Therapy, Present Centered Therapy
- Where
- 14 sites in United States
- Volunteers
- 426 people
- Sponsor
- Center for Veterans Research and Education
Opioid-use Disorder
Response to Relapse in Office-Based Opioid Treatment Trial
In a sample of individuals with co-occurring OUD and mental disorders, the investigators plan to test two medications for opioid use disorder (MOUD) treatment protocols that involve differing approaches to the use of opioids and…
- Trial name
- RR-OBOT (NCT03812107)
- Testing
- Moderate Treatment Approach, Intensive Treatment Approach
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Boston Medical Center
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Suvorexant for Treatment of AUD and PTSD
This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD), Insomnia
- Trial name
- SUV (NCT06679062)
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Anxiety Disorder, Posttraumatic Stress Disorder
Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use
Individual with anxiety and post-traumatic stress disorder often use alcohol in ways that could cause them harm. Treating both mental health concerns and alcohol use at the same time can help reduce difficulties engaging in…
- Conditions
- Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
- Trial name
- NCT04871100
- Testing
- Unified Protocol- Alcohol, Usual care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development