Clinical trials: Co-occurring Mental and Substance Use Disorders
Bipolar Disorder, Substance Use Disorder
Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders
This study is being done to see if icariin will help with depression in patients with bipolar disorder and alcohol or cocaine use disorders. The pills used in this study contain 20% icariin.
- Trial name
- NCT01979133
- Testing
- Icariin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT04587791
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Post Traumatic Stress Disorder, Alcohol Use Disorder
Zonisamide Outpatient Study
The objective of this study is to determine if, compared to placebo, zonisamide (400mg/day) is a safe and efficacious treatment for post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) in Veterans with PTSD and…
- Trial name
- NCT03376139
- Testing
- Zonisamide
- Where
- United States
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Cannabis Dependence, Tobacco Dependence
Varenicline for Co-occurring Cannabis and Tobacco Use
Pilot, eight week, open-label, within-subject cross over trial of four weeks of standard clinical care (SCC) in an outpatient substance use disorder treatment program and four weeks of SCC and varenicline among current and former…
- Trial name
- NCT04595318
- Testing
- Standard clinical care first, followed by standard clinical care and varenicline, Standard clinical care and varenicline first, followed by standard clinical care
- Volunteers
- 7 people
- Sponsor
- Albert Einstein College of Medicine
PTSD, Alcohol Use Disorder
Oxytocin to Enhance Integrated Treatment for AUD and PTSD
The primary objective of the proposed Stage II study is to examine the efficacy of oxytocin (OT) as compared to placebo in reducing (1) alcohol use disorder (AUD) symptoms, and (2) post-traumatic stress disorder (PTSD) symptoms…
- Trial name
- COPE+OT (NCT04523922)
- Testing
- 40 IU Intranasal Oxytocin, Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Depression, Substance Use Disorders
BA Trial for Co-Occurring Depression and Substance Use
A large proportion of people seeking treatment for drug and alcohol issues also have clinically significant depression symptoms.
- Trial name
- NCT03661580
- Testing
- Behavioural Activation, Treatment as Usual
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Sheffield
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder, Anxiety Disorder/Anxiety State
Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes
Alcohol dependence is among the most common and costly public health problems affecting the nation. Among individuals with alcohol use disorder (AUD), those with (vs.
- Conditions
- Alcohol Use Disorder, Anxiety Disorder/Anxiety State, Stress Disorder, Hypothalamic Pituitary Adrenal
- Trial name
- NCT03056872
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anxiety Disorders, Mood Disorders
Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders
The purpose of this study is to determine whether Integrated Treatment is effective in the treatment of anxiety and/or depression with co-occurring substance use disorders.
- Conditions
- Anxiety Disorders, Mood Disorders, Substance Use Disorders
- Trial name
- ROP (NCT00447733)
- Testing
- Integrated mental health and substance use treatment, Treatment as usual
- Volunteers
- 76 people
- Sponsor
- University of Oslo
Depression, Substance Use Disorders
Effectiveness of Depression and Substance Use Module for Patients With Co-occurring Disorders
The purpose of this study is to evaluate the adaptation and effectiveness of an integrated treatment module, the Depression and Substance Use Disorder Module (D-SUD-M), for male patients experiencing co-occurring depression and…
- Trial name
- D-SUD-M (NCT07705113)
- Testing
- Experimental Group: Treatment Module D-SUD-M, Control Group
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- International Islamic University, Islamabad
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Alcoholism, Alcohol Drinking
Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression
The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for…
- Conditions
- Alcoholism, Alcohol Drinking, Drinking Behavior, Alcohol-Related Disorders
- Trial name
- NCT04934553
- Testing
- Amplification of Positivity Training, Cognitive-behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Charles Taylor
Alcohol Use Disorder, Opioid Use Disorder
Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Opioid Use
This project aims to improve the health of individuals engaged in co-occurring alcohol and opioid use by supporting the maintenance of behavior change initiated in substance use treatment.
- Trial name
- NCT05325788
- Testing
- e-Covery, Comparator Condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Pain, Opioid Use Disorder
Mindfulness-Based Ecological Momentary Intervention for Opioid Use Disorder and Chronic Pain
The goal of this clinical trial is to evaluate whether a smartphone app-based ecological momentary intervention called Mindful Journey, which teaches mindfulness skills, can support adults in recovery from both opioid use…
- Trial name
- NCT06947122
- Testing
- Mindfulness based smartphone app
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Arizona State University
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Chronic Pain, Opioid-use Disorder
Pain and Opioids: Integrated Treatment In Veterans
This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD).
- Conditions
- Chronic Pain, Opioid-use Disorder, Opioids; Harmful Use
- Trial name
- POSITIVE (NCT04648228)
- Testing
- ACT+MBRP, Education control
- Where
- 4 sites in United States
- Volunteers
- 157 people
- Sponsor
- University of New Mexico
Concussion, Mild Traumatic Brain Injury, Brain Injury
Expanding Access to mTBI Treatment for Veterans and Service Members With Co-occurring Substance Use
The purpose of this research is to determine whether military veterans and service members with mild traumatic brain injury with and without co-occurring substance use can complete and benefit from integrated interdisciplinary…
- Conditions
- Concussion, Mild Traumatic Brain Injury, Brain Injury, Traumatic Brain Injury, Substance Use
- Trial name
- ExpandAccess (NCT06620900)
- Testing
- Integrated Model of Care
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Shepherd Center, Atlanta GA
Alcohol Use Disorder
Enhancing the Effects of Alcohol Treatment With L-Carnitine
The primary objective of this study is to evaluate the effects of L-carnitine, 2.97g daily on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 4 weeks of daily dosing among participants ages 18-25…
- Trial name
- NCT05355311
- Testing
- L-carnitine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown University
Posttraumatic Stress Disorder, Alcohol Use Disorder
Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD
The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD).
- Trial name
- CPT+RP (NCT05959434)
- Testing
- Cognitive Processing Therapy + Relapse Prevention, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Texas A&M University