Clinical trials: Coagulation
Blood Coagulation Disorders, Atrial Fibrillation
Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease
The purpose of this study is to evaluate the superiority of left atrial appendage occlusion in comparison to oral anticoagulation with a vitamin K antagonist (INR 2-3) related to the frequency of occurrence of at least one…
- Conditions
- Blood Coagulation Disorders, Atrial Fibrillation, Thrombosis of Left Atrial Appendage, Chronic Kidney Disease Stage 4
- Trial name
- WatchAFIB (NCT02039167)
- Testing
- Left atrial appendage occlusion
- Where
- 4 sites in Germany
- Volunteers
- 14 people
- Sponsor
- University of Magdeburg
Blood Coagulation Disorders
Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months
With the advent of measures to try to decrease the incidence of transfusion-related acute lung injury (TRALI), the Blood Bank industry is attempting to avoid collection of plasma from female donors who have been pregnant in order…
- Trial name
- NCT02774317
- Testing
- Plasma
- Where
- United States
- Sponsor
- University of Chicago
Septic Shock, Thrombocytopenia
Platelet Reactivity in Septic Shock
Coagulation disorders and thrombocytopenia are common in patients with septic shock. Despite the clinical relevance of sepsis-induced thrombocytopenia, few studies have focused on the prediction of thrombocytopenia in this…
- Conditions
- Septic Shock, Thrombocytopenia, Sepsis, Platelet Aggregation
- Trial name
- NCT03716310
- Testing
- platelet responsiveness evaluation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Coagulation Defect; Bleeding
ROTEM Versus aPTT/PT in Pediatric Surgery
Hemocoagulation management in perioperative bleeding is nowadays based on standard coagulation testing: activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, D-dimers, platelets.
- Trial name
- NCT03699813
- Testing
- Comparison of two approaches to bleeding management
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Focus of Study, Coagulation Status of Cardiac Surgery Patient
Thromboelastography-derived Functional Fibrinogen Levels
This study hopes to determine if thromboelastography-derived functional fibrinogen (TEG-FF or FLEV) levels obtained during the rewarming phase of cardiopulmonary bypass can provide information on coagulation status sooner…
- Conditions
- Focus of Study, Coagulation Status of Cardiac Surgery Patient, Reducing Excess Blood Transfusion
- Trial name
- TEG-FF (NCT01992757)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Pennsylvania
Health Education, Patient Education as Topic
Efficacy of a Didactic Intervention in Anticoagulated Patients (TAOPE Study)
Background: Oral anticoagulant drugs represent an essential tool in thrombo-embolic events prevention. Most used are vitamin K antagonists (VKA), which plasma level is monitored measuring prothrombin time using the International…
- Conditions
- Health Education, Patient Education as Topic, Blood Coagulation Tests
- Trial name
- TAOPE (NCT03647254)
- Testing
- Patient education group
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Francisco Javier Navarro Moya
Coagulation Disorder
Comparison of Two Point-of-care Devices for Viscoelastic Hemostasis Assays
This study will investigate the correlation and agreement of Quantra-derived parameters with parameters reported by the ROTEM delta and standard laboratory tests in cardiac surgery patients.
- Trial name
- NCT03685097
- Testing
- Quantra System with the QPlus Cartridge
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Blood Coagulation Tests
Evaluation of the Interference of Antithrombotic Agents With Laboratory Monitoring of Heparin Therapy
Oral anticoagulants are increasingly prescribed and the are not discontinued for invasive cardiac procedures . Additional parenteral anticoagulation is necessary for these procedures (FA ablation and invasive coronary…
- Trial name
- ACTARD (NCT02839434)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Disseminated Intravascular Coagulation
International Prospective Registry of Disseminated Intravascular Coagulation
Objectives: to evaluate the current diagnostic and therapeutic approaches for sepis-associated disseminated intravascular coagulation (DIC) in a large prospective registry.
- Trial name
- NCT03577015
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Marcella Muller
Blood Coagulation Test
Clinical Performance of the Investigational GEM Hemochron® 100 in Populations Ages 18 Years and Older
This study is designed to evaluate and verify the clinical accuracy of the Hemochron® MCS 7000 Whole Blood Microcoagulation System; a point-of-care, whole blood Activated Clotting Time (ACT) measurement in comparison with the…
- Trial name
- NCT03074266
- Testing
- GEM Hemochron 100 ACT
- Where
- 9 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Accriva Diagnostics
Coagulation Defect; Puerperal, Post Partum Hemorrhage
Bedside Assessment of Coagulation in Post-partum Hemorrhage by Thromboelastography (TEG ®6S)
Postpartum hemorrhage (PPH) is one of the leading causes of maternal deaths. Its prognosis is directly influenced by the early diagnosis and treatment of the associated coagulopathy.
- Conditions
- Coagulation Defect; Puerperal, Post Partum Hemorrhage, Blood Protein Disorders, Pregnancy Hemorrhage
- Trial name
- HPPTEG6S (NCT03592303)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coagulation Defects, Other and Unspecified
High-Shear Microfluidic Thrombosis Assay
The purpose of this study is to characterize a new test to assess the rate and time it takes to form a blood clot in people who either do or do not take aspirin.
- Trial name
- NCT02422810
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Emory University
Blood Coagulation Disorders
The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
This proposal is designed to mitigate hemodilution (blood diluted with an electrolyte solution) and loss of plasma proteins responsible for normal blood clotting as well as platelets at the completion of cardiopulmonary bypass…
- Trial name
- NCT01435304
- Testing
- method of returning residual CPB blood ( Hemobag®)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MaineHealth
Graves' Disease, Graves Ophthalmopathy
Coagulation After Intravenous Methylprednisolone Administration
The alterations of coagulation and fibrinolysis parameters have been described in patients with endogenous Cushing's syndrome (CS) and those treated with glucocorticosteroids (GCs).
- Conditions
- Graves' Disease, Graves Ophthalmopathy, Blood Coagulation, Venous Thromboembolism
- Trial name
- NCT03535090
- Testing
- Methylprednisolone
- Volunteers
- 26 people
- Sponsor
- Piotr Miskiewicz
Blood Coagulation
Safety of Oral Anticoagulants Registry
The goal of SOAR is to characterize the clinical and economic impact of clinicians' responses to major bleeding complications and pre-procedural concerns for bleeding risk in patients treated with oral anticoagulants (warfarin…
- Trial name
- SOAR (NCT02745054)
- Testing
- mgt of bleeding concerns/complications of oral anticoagulants
- Where
- 9 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Hospital Quality Foundation
Coagulation Disorder, Blood
Blood Transfusion and Postoperative Outcome Before and After Implementing a Coagulation Management Algorithm
Implementing coagulation management algorithms based on Point-of-care (POC) testing devices such as thromboelastography (TEG) or rotational thromboelastometry (ROTEM) have been shown to reduce transfusion rates and the occurrence…
- Trial name
- SONALG (NCT03482128)
- Testing
- Coagulation management guided by SONOCLOT, Standard coagulation management
- Where
- Switzerland
- Volunteers
- 1,754 people
- Sponsor
- Triemli Hospital
Dietary Supplements, Bleeding Tendency; Due to Coagulation Defect
ROTEM and Dietary Supplements
Dietary Supplements can affect platelet activation and aggregation, which could result in bleeding tendencies. This study wishes to evaluate the influence that these supplements has on platelet function using Rotational…
- Trial name
- NCT03125551
- Testing
- Ginger, Garlic, Ginkgo Biloba
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pretoria
Coagulation
Reference Range Study for the Quantra Analyzer With the Quantra Surgical Cartridge
This study will establish reference range intervals for the Quantra System, a next-generation diagnostic platform that provides whole blood coagulation testing at the point-of-care.
- Trial name
- NCT03139097
- Testing
- Quantra System
- Where
- 3 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- HemoSonics LLC
Blood Coagulation Disorders
Transfusion of Plasma Prior to Invasive Procedures Pilot Trial (TOPPIT)
Frozen plasma (FP) is commonly transfused to patients with abnormal coagulation results prior to medical procedures associated with a risk of bleeding (e.g. involving a needle or incision).
- Trial name
- TOPPIT (NCT02561026)
- Testing
- Frozen plasma
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Atrial Fibrillation, Metabolic Syndrome
Atherosclerosis in Atrial Fibrillation
The prevalence of metabolic syndrome in patients suffering from non valvular atrial fibrillation is derived from studies regarding recurrences of atrial fibrillation after catheter ablation.
- Conditions
- Atrial Fibrillation, Metabolic Syndrome, Oxidative Stress, Atherosclerosis
- Trial name
- NCT01882114
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- University of Roma La Sapienza