Clinical trials: Coagulation Disorder, Blood
Liver Cirrhosis, Coagulation Disorder
Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes
Rifaximin is an antibiotic that acts locally in the gastrointestinal tract with a broad spectrum of antibacterial activity. The efficacy of rifaximin is well documented in the prevention of acute hepatic encephalopathy.
- Conditions
- Liver Cirrhosis, Coagulation Disorder, Platelet Disorder, Endotoxemia
- Trial name
- NCT06630572
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Hemophilia A
Prospective, Non-interventional Study to Evaluate the Effectiveness of Elocta Compared to Conventional Factor Products
The purpose of the study is to evaluate the effectiveness of Elocta compared to conventional factor products in the prophylactic treatment of patients with haemophilia A over a 24-month prospective period.
- Trial name
- NCT02976753
- Testing
- efmoroctocog alfa, Factor VIII
- Where
- 36 sites in Austria, Belgium and 7 more
- Volunteers
- 361 people
- Sponsor
- Swedish Orphan Biovitrum
Haemophilia A, Haemophilia B
A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or B
Elocta (rFVIIIFc) and Alprolix (rFIXFc) are recombinant extended half-life coagulation factor products. The purpose of this non-interventional study is to describe the real-world usage and effectiveness of Elocta and Alprolix in…
- Trial name
- PREVENT (NCT03055611)
- Testing
- ELOCTA, ALPROLIX
- Where
- 22 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Swedish Orphan Biovitrum
Hemophilia a, Hemophilia B
Study of TU7710 in Warfarin Anti-coagulated Healthy Male Subjects
This is a Phase 1a, double-blind, randomized, placebo- controlled, SAD study to assess safety, tolerability, PK, and PD of TU7710 in warfarin treated healthy male participants.
- Conditions
- Hemophilia a, Hemophilia B, Blood Coagulation Disorders
- Trial name
- NCT06025552
- Testing
- TU7710, Normal saline
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TiumBio Co., Ltd.
Haemophilia B
A Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B in France
Alprolix (rFIXFc) is a recombinant extended half-life coagulation factor product. The purpose of this non-interventional study is to describe the real-world usage and effectiveness of Alprolix in the on-demand and prophylactic…
- Trial name
- B-SURE (NCT03655340)
- Testing
- Alprolix
- Where
- 18 sites in France
- Volunteers
- 91 people
- Sponsor
- Swedish Orphan Biovitrum
Blood Coagulation Disorder
The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin
The aim of this project is to assess the influence of exercise on pharmacokinetics (PK) and pharmacodynamics (PD) of a single dose of subcutaneously (sc) administered unfractionated heparin (UFH).
- Trial name
- NCT06174961
- Testing
- Unfractionated heparin, Double-legged cycle ergometer exercise, Single-legged cycle ergometer exercise, with unfractionated heparin injection in the exercising leg
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Kristian Karstoft
Haemophilia A, Haemophilia B
Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and B
The puropse of this non-interventional register and survey study is to identify the patterns of prescribed pain, anti-depressive and anti-anxiety medication and management of pain, depression and anxiety for people with…
- Trial name
- MIND (NCT03276130)
- Where
- 5 sites in Denmark, Finland and 1 more
- Volunteers
- 2,300 people
- Sponsor
- Swedish Orphan Biovitrum
Head and Neck Cancer, Intraoperative Complications
Coagulation and Vitamin K in Head and Neck Microvascular Free Flap Surgery
For patients with large head and neck tumors the recommended treatment, in many cases, is a combination of extensive surgery and postoperative radiotherapy.
- Conditions
- Head and Neck Cancer, Intraoperative Complications, Coagulation Disorder, Blood, Vitamin K Deficiency
- Trial name
- MVL-COAG (NCT04517461)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Adeno-Associated Virus (AAV), Blood Coagulation Disorder
Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors
SPK-8016 is in development for the treatment of patients with inhibitors to FVIII. This Phase 1/2, open-label, non-randomized, dose-finding study to evaluate the safety, efficacy, and tolerability of SPK-8016 in adult males with…
- Conditions
- Adeno-Associated Virus (AAV), Blood Coagulation Disorder, Blood Coagulation Disorders, Inherited, Coagulation Protein Disorders
- Trial name
- NCT03734588
- Testing
- SPK-8016
- Where
- 11 sites in United States
- Volunteers
- 4 people
- Sponsor
- Spark Therapeutics, Inc.
Pre-Eclampsia; Complicating Pregnancy, Blood Loss
Blood Loss and Preeclampsia
Study of blood loss in preeclamptic patients using mathematical formulae
- Conditions
- Pre-Eclampsia; Complicating Pregnancy, Blood Loss, Coagulation Disorder
- Trial name
- NCT04777097
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Hemophilia A
A Study to Learn More About Treatment With Damoctocog Alfa Pegol, How it is Used in Every Day Practice ("Real-World"), and How Satisfied People Who Receive Damoctocog Alfa Pegol Are in United States (US) Hemophilia Treatment Centers
People with hemophilia A do not have enough of a protein found naturally in the blood called "clotting factor 8", also known as FVIII. This protein helps the blood to clump together to prevent and stop bleeding.
- Trial name
- REAL (NCT05395858)
- Testing
- No intervention
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Bayer
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Hemophilia A
Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg
This Phase III clinical study will assess the efficacy of BMN 270 defined as FVIII activity, during weeks 49-52 following intravenous infusion of BMN 270 and assess the impact of BMN 270 on usage of exogenous FVIII replacement…
- Trial name
- GENEr8-2 (NCT03392974)
- Testing
- Valoctocogene Roxaparvovec
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- BioMarin Pharmaceutical
Kidney Disease, Chronic, Pediatric Kidney Disease
Hemostatic Profiles in Pediatric CKD
This cross-sectional pilot study will examine the blood clotting patterns in children with chronic kidney disease stages 3, 4, and 5.
- Conditions
- Kidney Disease, Chronic, Pediatric Kidney Disease, Renal Insufficiency, Chronic, Blood Coagulation Disorders in Children
- Trial name
- NCT05064267
- Testing
- phlebotomy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's Healthcare of Atlanta
Psoriasis, Inflammation
Subclinical Impairment of Cardiovascular System in Patients With Psoriasis
A cross-sectional study will be conducted, which will include 80 young patients with psoriasis, aged 30-45 years, treated with five different types of antipsoriatic treatment, and 20 healthy patients.
- Conditions
- Psoriasis, Inflammation, Endothelial Dysfunction, Metabolic Disturbance
- Trial name
- PaS (NCT05957120)
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Neoplasm Metastasis, Blood Coagulation Disorder With Shortened Coagulation Time (Disorder)
Application of a New Type of Whole Blood Coagulation Time Measurement in Evaluating the Hypercoagulable State of Malignant Tumors
Malignant tumors are closely related to deep vein thrombosis, Pulmonary embolism and other diseases. Tumor patients usually have a hypercoagulable state (HCS) in their blood, and the proportion of thrombosis caused by HCS is more…
- Conditions
- Neoplasm Metastasis, Blood Coagulation Disorder With Shortened Coagulation Time (Disorder), Venous Thromboembolism
- Trial name
- GCTHCM (NCT05939960)
- Testing
- CGT test
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Tianjin Medical University General Hospital
Blood Coagulation Disorder, Blood Coagulation Disorders, Inherited
Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants
The aim of this prospective, observational study is to establish a dataset on the frequency of bleeding events, as well as other characteristics of bleeding events and FVIII infusions, in patients with clinically severe…
- Conditions
- Blood Coagulation Disorder, Blood Coagulation Disorders, Inherited, Coagulation Protein Disorders, Hemophilia A
- Trial name
- NCT03876301
- Testing
- Standard of Care FVIII Replacement therapy
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 25 people
- Sponsor
- Spark Therapeutics, Inc.
Hemorrhagic Shock, Blood Coagulation Disorders
Study Using Plasma for Patients Requiring Emergency Surgery
Information on the management of casualties from the ongoing conflicts in Afghanistan and Iraq has brought in to question the traditional approach to blood transfusion in hemorrhaging patients.
- Conditions
- Hemorrhagic Shock, Blood Coagulation Disorders, Blood Products, Trauma
- Trial name
- SUPPRES (NCT01221389)
- Testing
- Human Plasma
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Blood Coagulation Disorder
Biomarkers and Prediction of Tigecycline Induced Coagulation Dysfunction
This study is to screen out the biomarkers and establish the model to predict coagulation dysfunction induced tigecycline
- Trial name
- NCT05698160
- Volunteers
- 200 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Blood Coagulation Disorder
Ondansetron and Blood Coagulation
Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron.
- Trial name
- NCT04499274
- Testing
- 0 ul of ondansetron, 0.2 ul of ondansetron, 2 ul of ondansetron
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital