Clinical trials: Cocaine
Cocaine Use Disorder
A Study to Evaluate EMB 001 in Subjects With Cocaine Use Disorder
EMB-001 is a combination of 2 drugs: the cortisol synthesis inhibitor, metyrapone (Metopirone®), and the benzodiazepine receptor agonist, oxazepam (original trade name Serax®; now marketed as oxazepam (generic) only).
- Trial name
- NCT04501874
- Testing
- EMB-001
- Where
- 4 sites in United States
- Volunteers
- 82 people
- Sponsor
- Embera NeuroTherapeutics, Inc.
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Mild Cognitive Impairment, So Stated, Cocaine Use Disorder
Occupational Therapy-Based Cognitive Rehabilitation of Cocaine Abusers: A Pilot Study
This study integrates a model of occupational-therapy based cognitive rehabilitation as part of a comprehensive treatment plan for cocaine abusers.
- Trial name
- NCT01684293
- Testing
- Occupational therapy-based cognitive rehabilitation, Psychoeducation/games
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Cocaine Dependence, Cocaine Withdrawal
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
- Trial name
- NCT01171183
- Testing
- controlled release carvedilol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Amphetamine-Related Disorders, Cocaine-Related Disorders
Computerized Exercise to Alter Stimulant Approach Responses
The purpose of this study is to evaluate the Computerized Exercise to Alter Stimulant Approach Responses (CEASAR), a novel stimulant use cessation intervention, for clients currently enrolled in a treatment centre for mental…
- Conditions
- Amphetamine-Related Disorders, Cocaine-Related Disorders, Substance-Related Disorders
- Trial name
- CEASAR (NCT03902405)
- Testing
- Active CEASAR Intervention
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Drug Abuse, Cocaine Dependence
Reward Processing in Cocaine Addiction
Background: Cocaine affects the brain's ability to process information. However, different people respond to cocaine in different ways, and differences in brain structure and function may affect how cocaine alters brain activity.
- Trial name
- NCT01036074
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol-Related Disorders, Cocaine-Related Disorders
Disulfiram for Cocaine-Alcohol Abuse - 3
The purpose of this study is to evaluate disulfiram for cocaine-alcohol abuse.
- Trial name
- NCT00000278
- Testing
- Disulfiram
- Where
- United States
- Sponsor
- Yale University
Orbital Floor (Blow-Out) Open Fracture, Enophthalmos Traumatic
3D Printed Titanium Mesh vs Guided Autogenous Graft
In this study, the hypothesis states that there is no significant difference between specified populations. In our case, the 3D printed patient-specific titanium mesh is thought to have the same effect and results in comparison…
- Trial name
- NCT05550285
- Testing
- orbital floor recontriction
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Mohammed Ghassan Mohammed Shaalan
Cocaine Abuse, Cocaine Dependence
Progesterone for Postpartum Cocaine Relapse
The investigators propose a placebo-controlled, randomized clinical trial that would enroll 50 postpartum women with a history of cocaine abuse or dependence to assess whether progesterone (100mgs twice daily) decreases…
- Trial name
- NCT01249274
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Cocaine Dependence
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Currently, no effective drug treatment exists for cocaine dependence. Glutamate levels are disrupted with long-term cocaine use.
- Trial name
- NAC (NCT00218491)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse…
- Trial name
- NCT01535937
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Craving, Emotional Dysfunction
Process of Regulation in Addictions: Vulnerability Emotional Factors to Craving
The aim of this study is to have a better understanding of the relationship between self-controle difficulties (and more specifically the inhibition deficit in impulsivity), emotional regulation disorders such as alexithymia and…
- Conditions
- Craving, Emotional Dysfunction, Self-Regulation, Emotion, Alexithymia
- Trial name
- Procrav (NCT05076201)
- Testing
- Patients with completed rehab
- Where
- France
- Volunteers
- 80 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 1
The purpose of this study is to evaluate the effects of desipramine DMI maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.
- Trial name
- NCT00000212
- Testing
- Desipramine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Cocaine Effects in Humans: Physiology and Behavior - 1
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving, in opiate-dependent cocaine…
- Trial name
- NCT00000200
- Testing
- Methadone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Alcoholism
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol and cocaine dependence.
- Trial name
- NCT00167232
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Brain Function and Structure in Cocaine Dependence
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
- Trial name
- NCT02080832
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder (CUD), Cognitive Impairments
The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
The study aims to address the neurobiological basis of cognitive impairments in chronic cocaine users by investigating the potential impact of an acute potassium channel blockade on working memory performance and other cognitive…
- Trial name
- POTCHICUD (NCT07532460)
- Testing
- 4-aminopyridine (4-AP)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Boris Quednow
Cocaine Dependence
Beta-blockade Effects on Memory for Cocaine Craving
The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.
- Trial name
- NCT00830362
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina