Clinical trials: Cocaine Abuse
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Seroconversion, Stimulant Abuse
Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
This study seeks to evaluate the efficacy of a contingency management (CM) intervention compared to a yoked control condition for eliminating illicit stimulant use and for decreasing time to initiating post exposure prophylaxis…
- Trial name
- NCT01140880
- Testing
- Truvada
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Substance Abuse
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
This placebo-controlled, double-blind, randomized pilot clinical trial will evaluate atomoxetine (Strattera®) for the treatment of cocaine dependence.
- Trial name
- NCT00617201
- Testing
- atomoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine Abuse
Effects of Aripiprazole on Cocaine Craving and Self-Administration
The purpose of this study is to investigate whether aripiprazole will decrease cocaine self-administration, subjective effects and cravings compared to placebo.
- Trial name
- NCT00373880
- Testing
- Aripiprazole + Cocaine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Atomoxetine for Treating Cocaine Abuse in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Studies have shown that individuals with attention deficit hyperactivity disorder (ADHD) are at greater risk for having a substance use disorder compared to people who do not have ADHD.
- Trial name
- Atom (NCT00218543)
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Abuse
CBT With Disulfiram and Contingency Management
This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).
- Trial name
- NCT00350870
- Testing
- disulfiram, Disulfiram plus Contingency Management
- Where
- United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Use Disorder, Substance Use Disorders
Multiple Ascending Dose Study of TMP-301 in Healthy Subjects
A PHASE 1, RANDOMIZED, PLACEBO CONTROLLED, MULTIPLE ASCENDING DOSE (MAD) STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF TMP-301 IN HEALTHY SUBJECTS.
- Conditions
- Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
- Trial name
- NCT06025396
- Testing
- Cohort 1 - TMP-301, Cohort 2 - TMP-301, Cohort 3 - TMP-301
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tempero Bio, Inc.
Cocaine Dependence
Caffeine and Cocaine
This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse.
- Trial name
- NCT00733993
- Testing
- Caffeine 150 MG, Amphetamine, Caffeine 300 MG
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence, Depression
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
This research study is being done to look at the safety of the medication Mirtazapine (Remeron) in people who have cocaine dependence and depression. Hypotheses I.
- Trial name
- NCT00322309
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University