Clinical trials: Cocaine Abuse
Cocaine-Related Disorders, Substance-Related Disorders
Quetiapine for Cocaine Use and Cravings
The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals.
- Trial name
- NCT00232336
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Stimulant Abuse, HIV Prevention
Integrated BA and HIV RR Counseling for MSM With Stimulant Abuse
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the efficacy of Project IMPACT, an intervention that integrates Behavioral Activation (BA) with HIV risk reduction (RR) counseling for…
- Conditions
- Stimulant Abuse, HIV Prevention, Substance Abuse
- Trial name
- NCT03175159
- Testing
- IMPACT, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Neural Systems, Drug Abuse
PET Assays of Striatal Dopamine Marker in Cocaine Craving
Background: Cues related to past drug use induce a particular pattern of brain activation, which has been correlated with craving for cocaine in active cocaine abusers.
- Conditions
- Neural Systems, Drug Abuse, Cocaine Dependence
- Trial name
- NCT01036516
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate-Related Disorders, Cocaine-Related Disorders
Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency Management
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292110
- Testing
- Methadone, Contingency Management, Methadone dose
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 2
The purpose of this study is to evaluate the effects of fluoxetine maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.
- Trial name
- NCT00000213
- Testing
- Fluoxetine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Tryptophan and Behavior Therapy for Cocaine Abuse - 1
The purpose of this study is to assess the efficacy of tryptophan vs. placebo, and voucher payments vs. a control condition, in the treatment of cocaine dependence.
- Trial name
- NCT00000324
- Testing
- Tryptophan
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Addiction
Comparing Acute and Continuous Drug Abuse Treatment: A Randomized Clinical Trial
The purpose of this 2 year study is to conduct a fully powered effectiveness trial comparing recovery trajectories of 200 drug dependent adults (the subjects) who will be randomly assigned to Treatment as Usual (TAU) or TAU +…
- Trial name
- NCT01003496
- Testing
- Treatment as Usual (TAU), TAU + Long-Term Recovery Management
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Wright State University
Cocaine Dependence, Cannabis Dependence
Risk Perception in Drug-Dependent Adults With and Without Schizophrenia
Background: Several studies of risk perception have demonstrated a common bias known as unrealistic optimism, in which individuals feel they are less likely than other people to experience unpleasant or harmful events in their…
- Conditions
- Cocaine Dependence, Cannabis Dependence, Schizophrenia
- Trial name
- NCT01031563
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder, Crack Abuse or Dependence
Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder
This is a single-center, randomized intervention study in a volunteer population of patients with cocaine/crack use disorder to evaluate the pharmacological treatment of cocaine/crack craving, comparing the drug clonidine with…
- Trial name
- NCT07313371
- Testing
- clonidine, clonazepam 0,25 mg
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
HIV Seroconversion, Stimulant Abuse
Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
This study seeks to evaluate the efficacy of a contingency management (CM) intervention compared to a yoked control condition for eliminating illicit stimulant use and for decreasing time to initiating post exposure prophylaxis…
- Trial name
- NCT01140880
- Testing
- Truvada
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Cocaine Abuse
Prize Contingency Management for Cocaine-Dependent Methadone Patients
The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and…
- Trial name
- NCT01401270
- Testing
- prize contingency management
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- UConn Health
Addiction, Opioid Dependence
Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction
The purpose of this study is determine the safety, efficacy and tolerability of a novel drug APH-1501 as a pharmacotherapy for Opioid Dependence. The investigators will evaluate the safety of escalating doses APH-1501.
- Conditions
- Addiction, Opioid Dependence, Opioid Withdrawal
- Trial name
- NCT03813095
- Testing
- APH-1501
- Volunteers
- 32 people
- Sponsor
- Aphios
Cocaine Abuse, Cocaine-Related Disorders
Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent Individuals
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218049
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine Dependence
Substance Abuse Pre-Treatment Screening Study
The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for…
- Conditions
- Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00439049
- Testing
- modafinil, d-amphetamine, L-Dopa
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Enhanced and Attendance-based Prize CM in Community Settings
The purpose of this study is to address the conditions under which prize contingency management (CM) for abstinence and attendance may improve outcomes of cocaine-dependent patients.
- Trial name
- NCT00606853
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 443 people
- Sponsor
- UConn Health
Cocaine Dependence
Cocaine Use Reduction With Buprenorphine
The aim of this study is to investigate the safety and effectiveness of buprenorphine in the presence of naltrexone for the treatment of cocaine dependence.
- Trial name
- CURB (NCT01402492)
- Testing
- Buprenorphine + Naltrexone
- Where
- 11 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of California, Los Angeles