Clinical trials: Cocaine Addiction
Cocaine Dependence
Modafinil Treatment for Cocaine Dependence and HIV High-Risk Behavior
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces high risk behavior in cocaine dependent subjects.
- Trial name
- MOD6 (NCT00368290)
- Testing
- Modafinil, Cognitive Behavioral Therapy (CBT)
- Volunteers
- 94 people
- Sponsor
- Kyle Kampman
Cocaine Dependence
Modafinil for Smoked Cocaine Self-Administration
Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied.
- Trial name
- NCT01778010
- Testing
- Modafinil 0 mg, Modafinil 200 mg, Modafinil 400 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Therapeutic Cocaine Vaccine: Human Laboratory Study
Clinical data demonstrate that a cocaine vaccine (TA-CD: Celtic Pharmaceutical) produces selective anti-cocaine antibodies, yet the impact of these antibodies on cocaine's direct effects is unknown.
- Trial name
- NCT00965263
- Testing
- Cocaine vaccine (TA-CD)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Addiction
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving
We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue…
- Trial name
- LIDO (NCT01929343)
- Testing
- lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Bryon Adinoff
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Crack-cocaine Addiction
In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics for substance abuse disorder treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive…
- Trial name
- tDCS_CRACK (NCT02091167)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Cocaine Dependence
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer program.
- Trial name
- NCT00809835
- Testing
- Galantamine, Computer Assisted Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Cocaine Abuse, Cocaine Dependence
Progesterone for Postpartum Cocaine Relapse
The investigators propose a placebo-controlled, randomized clinical trial that would enroll 50 postpartum women with a history of cocaine abuse or dependence to assess whether progesterone (100mgs twice daily) decreases…
- Trial name
- NCT01249274
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Cocaine Dependence
Caffeine and Cocaine
This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse.
- Trial name
- NCT00733993
- Testing
- Caffeine 150 MG, Amphetamine, Caffeine 300 MG
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
5HT2CR Balance in Brain Connectivity in Cocaine Dependence
This project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as compared to non-drug using controls.
- Trial name
- NCT03921151
- Testing
- Mirtazapine 15 MG Oral Tablet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Cognitive Remediation for Cocaine Dependence
The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.
- Trial name
- NCT01393457
- Testing
- levodopa/carbidopa, Ropinirole 2 mg/d, Ropinirole 4 mg/d
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Dependence, Opioid Dependence
Pharmacogenetics of Disulfiram for Cocaine
Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment.
- Trial name
- Disulfiram (NCT00149630)
- Testing
- Disulfiram, Methadone, CBT
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Baylor College of Medicine
Cocaine Use Disorder, Alcohol Use Disorder
PPARγ Agonist Treatment for Cocaine Dependence
The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine…
- Trial name
- NCT02774343
- Testing
- Pioglitazone, Therapy, Contingency Management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence, Opiate Dependence
Cocaine Withdrawal and Pharmacotherapy Response
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day)…
- Trial name
- Carvedilol (NCT00566969)
- Testing
- sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Yale University
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Substance Use Disorders, Contingency Management
Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil
Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or…
- Conditions
- Substance Use Disorders, Contingency Management, Addiction, Cocaine
- Trial name
- NCT03345394
- Testing
- Contingency Management, Standard treatment
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Federal University of São Paulo
Methamphetamine or Cocaine Dependence
Doxazosin for Psychostimulant Dependence
Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder.
- Trial name
- NCT01371851
- Testing
- Doxazosin extended release
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arkansas