Clinical trials: Cocaine Addiction
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Related Disorders
Contingency Management Treatment for Crack Addiction - Study With Brazilian Population
Crack addiction has become a severe health problem in Brazil. Today, crack addiction is the primary cause for inpatient treatment for all illicit substances.
- Trial name
- NCT01815645
- Testing
- ST+CM, standard treatment
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Federal University of São Paulo
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer program.
- Trial name
- NCT00809835
- Testing
- Galantamine, Computer Assisted Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Alcohol Use, Drug Use
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators.
- Conditions
- Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
- Trial name
- NCT00249496
- Testing
- Contingency management, Employment Only
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Cocaine Dependence, Cocaine Withdrawal
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
- Trial name
- NCT01171183
- Testing
- controlled release carvedilol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Cocaine Abuse, Cocaine Dependence
Progesterone for Postpartum Cocaine Relapse
The investigators propose a placebo-controlled, randomized clinical trial that would enroll 50 postpartum women with a history of cocaine abuse or dependence to assess whether progesterone (100mgs twice daily) decreases…
- Trial name
- NCT01249274
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Cocaine Dependence
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Currently, no effective drug treatment exists for cocaine dependence. Glutamate levels are disrupted with long-term cocaine use.
- Trial name
- NAC (NCT00218491)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse…
- Trial name
- NCT01535937
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Dependence
Brain Function and Structure in Cocaine Dependence
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
- Trial name
- NCT02080832
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Beta-blockade Effects on Memory for Cocaine Craving
The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.
- Trial name
- NCT00830362
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence, Depression
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
This research study is being done to look at the safety of the medication Mirtazapine (Remeron) in people who have cocaine dependence and depression. Hypotheses I.
- Trial name
- NCT00322309
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Cocaine Dependence
Effectiveness of Extended Treatments for Drug Dependence
This study tests the effectiveness of two 24 month, telephone-based adaptive continuing care interventions for patients with cocaine dependence.
- Trial name
- ETDD (NCT00685659)
- Testing
- Intensive Outpatient Treatment, Adaptive telephone-based counseling, Adaptive telephone-based counseling plus incentives
- Where
- 2 sites in United States
- Volunteers
- 332 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
A Multi-Center Trial of Nepicastat for Cocaine Dependence
The objective of this study is to evaluate the safety and efficacy of Nepicastat in improving the number of subjects that achieve abstinence from cocaine and reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT01704196
- Testing
- Nepicastat
- Where
- 10 sites in United States
- Volunteers
- 179 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-related Disorder
Study to Investigate Whether AFQ056 Reduces Cocaine Use in Patients Diagnosed With Cocaine Use Disorder (CUD)
This study assessed whether AFQ056 had a beneficial effect by reducing cocaine use in Cocaine Use Disorder (CUD) patients as assessed by Timeline Follow-Back cocaine self-report.
- Trial name
- NCT03242928
- Testing
- AFQ056
- Where
- 8 sites in Argentina, Spain and 1 more
- Volunteers
- 68 people
- Sponsor
- Novartis Pharmaceuticals