Clinical trials: Cocaine Related Disorders
Cocaine-Related Disorders
Selegiline in Treatment of Cocaine Dependence - 2
The purpose of this study is to assess selegiline as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000188
- Testing
- Selegiline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorder, Opiate Dependence
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
This 18-week, randomized, double blind clinical trial provided treatment for 160 cocaine-dependent opioid addicts, aged 18-65 years.
- Trial name
- NCT00580827
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Yale University
Cocaine-Related Disorders, Drug Administration Schedule
Evaluation of Modafinil as a Cocaine Treatment Medication and Interactions With Cocaine - 1
The purpose of this study is to evaluate modafinil, a cocaine treatment medication, and its interactions with intravenous (IV) cocaine.
- Conditions
- Cocaine-Related Disorders, Drug Administration Schedule, Infusions, Intravenous
- Trial name
- NCT00033046
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction, Treatment
Effects of Repeated Transcranial Magnetic Stimulation (rTMS) on the Treatment of Cocaine Addicted Patients
Cocaine addiction is a serious disease. Nowadays we still have no efficient method reducing craving and extending the abstinence period of this patients during treatment.
- Conditions
- Cocaine Addiction, Treatment, Transcranial Magnetic Stimilation
- Trial name
- TMSCOCDEPEND (NCT01259362)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine-Related Disorders
Dose Response Trial of Pergolide for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.
- Trial name
- NCT00000248
- Testing
- Pergolide
- Where
- United States
- Sponsor
- Medical University of South Carolina
Cocaine-related Disorders
Buprenorphine Naltrexone-P1 A-Cocaine
The purpose of this study is to determine if the opioid agonist effects of doses of 4/1 mg, 8/2 mg, and 16/4 mg of buprenorphine/naloxone can be completely blocked by 50 mg of oral naltrexone.
- Trial name
- NCT00733720
- Testing
- Suboxone
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern
Drug Abuse
Stimulant Abuser Groups to Engage in 12-Step
The purpose of this study is to determine whether a combined group and individual 12-Step facilitative (TSF) intervention, Stimulant Abuser Groups to Engage in 12 -Step (STAGE-12), improves substance -related outcomes.
- Trial name
- STAGE-12 (NCT00573183)
- Testing
- STAGE-12, Treatment as Usual
- Where
- 10 sites in United States
- Volunteers
- 471 people
- Sponsor
- University of Washington
Cocaine-Related Disorders
Effects of Labetalol on Human Cocaine Use - 8
The purpose of this study is to determine the effect of labetalol treatment on the subjective and physiological effects of cocaine.
- Trial name
- NCT00000291
- Testing
- Labetalol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use, Opioid Use Disorder
Treating Polysubstance Use Using a Novel Digital Technology
The goal of this clinical trial is to determine the effects of an app to reduce opioid and cocaine use when layered atop methadone treatment as usual among people using both opioids and cocaine.
- Conditions
- Opioid Use, Opioid Use Disorder, Cocaine Use, Cocaine Use Disorder
- Trial name
- POLY (NCT05766631)
- Testing
- DynamiCare Health, Methadone Treatment-As-Usual
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- Friends Research Institute, Inc.
Cocaine-Related Disorders, Heroin Dependence
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users.
- Conditions
- Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00149669
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder
Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder
Cocaine is the 2nd most used illicit substance in Europe and its use implies numerous health complications as well as an annual social cost of 8.7 G d'€.
- Trial name
- PICOC (NCT05833529)
- Testing
- Virtual Reality Cue Exposure (VRCE) Therapy for Cocaine Craving - 2 weeks, Memory Focused Cognitive Therapy (MFCT) - 1 week, Pictures-based Cue Exposure (PCE) Therapy for Cocaine Craving - 3 weeks
- Where
- 2 sites in Martinique
- Volunteers
- 54 people
- Sponsor
- Thomas Lehoux
Cocaine Dependence, Substance-induced Sleep Disorder
Modafinil, Sleep, and Cognition in Cocaine Dependence
Subjects participating in this protocol will participate in three phases: 1) pre-admission, 2) inpatient admission, and 3) follow-up.
- Conditions
- Cocaine Dependence, Substance-induced Sleep Disorder, Substance-induced Cognitive Disorder
- Trial name
- NCT00582491
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Effects of Carvedilol on Cocaine Use in Humans - 11
The purpose of this study is to examine carvedilol effects in response to cocaine.
- Trial name
- NCT00000294
- Testing
- Carvedilol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Enhanced and Attendance-based Prize CM in Community Settings
The purpose of this study is to address the conditions under which prize contingency management (CM) for abstinence and attendance may improve outcomes of cocaine-dependent patients.
- Trial name
- NCT00606853
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 443 people
- Sponsor
- UConn Health
Cocaine-Related Disorders
Infusion Laboratory: Protocol 5 (Flupenthixol) - 14
The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as…
- Trial name
- NCT00000349
- Testing
- Flupenthixol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Exercise as an Adjunctive Treatment for Cocaine Dependent Patients
The purpose of this study is to evaluate if exercise added to usual treatment improves cocaine dependence treatment. The primary objective of this study is to investigate if exercise can facilitate cocaine craving reduction.
- Trial name
- NCT01832649
- Testing
- Exercise, Health education
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cocaine-Related Disorders
Infusion Laboratory: Protocol 2 (Lisuride) - 3
The purpose of this study is to evaluate clinical safety issues pertaining to lisuride, to cocaine, and to its interaction in a chronic, crack dependent population, and to determine how pretreatment with lisuride modifies the…
- Trial name
- NCT00000338
- Testing
- Lisuride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effectiveness and Costs of Enhanced Cocaine Treatments
The study will evaluate the effectiveness, economic benefits, and costs of voucher reinforcement for cocaine and alcohol abstinence, additional counseling services, and their combination in a sample of cocaine dependent patients…
- Trial name
- NCT00167258
- Testing
- Voucher Reinforcement, Extra Counseling Services, Voucher Reinforcement + Extra Counseling Services
- Where
- United States
- Sponsor
- University of Pennsylvania