Clinical trials: Cocaine Related Disorders
Cocaine Dependence
A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
This is a double-blind placebo-controlled clinical trial (n = 156) of varenicline for the treatment of cocaine dependence that utilizes contingency management to promote treatment attendance.
- Trial name
- NCT01680887
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder, Cocaine Dependence
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
- Trial name
- NCT05857852
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Drug Use, Substance Abuse
Harm Reduction Services
The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve harm reduction service utilization among Black and Latinx people who…
- Conditions
- Drug Use, Substance Abuse, Mental Illness
- Trial name
- HRS (NCT05776316)
- Testing
- Integrated Harm Reduction Intervention (IHRI)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Cocaine Dependence, Opioid Dependency
Disulfiram for Cocaine Abuse in Buprenorphine Treatment
The investigators are proposing a placebo-controlled clinical trial to evaluate the efficacy and potential mechanisms of action of disulfiram (versus placebo) for treating cocaine abuse in subjects with concurrent opiate…
- Trial name
- NCT00913484
- Testing
- Disulfiram
- Where
- 2 sites in United States
- Volunteers
- 177 people
- Sponsor
- Yale University
Adult Attention Deficit Hyperactivity Disorder, Cocaine Dependence
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
The proposed protocol is a 3 group double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) in the treatment of comorbid ADHD and cocaine dependence.
- Trial name
- CAMP (NCT00553319)
- Testing
- Adderall-XR
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Abuse
Galantamine Effects on Cognitive Function in Abstinent Cocaine Users
To evaluate galantamine's effects on cognitive performance in abstinent cocaine users. Galantamine, a medication approved for treatment of Alzheimer's disease, is an acetylcholine esterase inhibitor.
- Trial name
- NCT00606801
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Modafinil Treatment for Cocaine-Dependent Individuals
Despite years of active research, there are still no approved medications for the treatment of cocaine dependence. The purpose of this study is to determine the effectiveness of modafinil in treating cocaine-dependent individuals.
- Trial name
- NCT00129285
- Testing
- Low Dose Modafinil, High Dose Modafinil
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Topiramate to Reduce Cocaine Dependence
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Topiramate, a medication which lowers dopamine levels, may have the ability to diminish cocaine cravings in addicts.
- Trial name
- NCT00223626
- Testing
- Topiramate
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Bankole Johnson
Cocaine-Related Disorders
Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine use in depressed and non-depressed females with cocaine abuse/dependence.
- Trial name
- NCT00000293
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effects of Vigabatrin on Cocaine Self-Administration
The objective of this study is to determine if vigabatrin will decrease cocaine self-administration, cardiovascular effects, subjective effects and craving compared to placebo.
- Trial name
- NCT00373581
- Testing
- Vigabatrin, Cocaine
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Drug Addiction
Treating the Partners of Drug Using Pregnant Women: Stage II
This is a two group randomized design that will compare a novel therapy package (i.e., Research supported treatment intervention, Contingency-based voucher incentives for the male partner's drug abstinence, Specialized MI couples…
- Trial name
- HOPE (NCT00496990)
- Testing
- Enhanced care, control
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Modafinil Treatment for Cocaine Dependence and HIV High-Risk Behavior
The purpose of study is to determine if modafinil promotes cocaine abstinence and reduces high risk behavior in cocaine dependent subjects.
- Trial name
- MOD6 (NCT00368290)
- Testing
- Modafinil, Cognitive Behavioral Therapy (CBT)
- Volunteers
- 94 people
- Sponsor
- Kyle Kampman
Cocaine Dependence, Cocaine Use Disorder
Predicting Relapse After Cocaine Inpatient Cessation
Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.
- Trial name
- QUIT-COC (NCT02416050)
- Testing
- Brain MRI imagery
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Substance Use Disorders, Opioid Use Disorder
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
The overarching goal of this study phase, Phase II component is to implement Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR) device in substance use disorder (SUD)…
- Conditions
- Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder
- Trial name
- EDITOR (NCT06434818)
- Testing
- EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Evon Medics LLC
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 2
The purpose of this study is to evaluate the effects of fluoxetine maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.
- Trial name
- NCT00000213
- Testing
- Fluoxetine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine-Related Disorders
Naltrexone in Treatment of Cocaine Dependence - 5
The purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2) decreased cocaine use by self-report, 3) decreased…
- Trial name
- NCT00015080
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Mental Disorder
Cost Effective Treatment for Dually Diagnosed Homeless
This randomized controlled trial examined whether an abbreviated treatment using abstinence contingency management for housing and work/training (CM, n=103) with cocaine dependent, non-psychotic, dually diagnosed homeless…
- Conditions
- Cocaine Dependence, Mental Disorder, Homelessness, Unemployment
- Trial name
- NCT00368524
- Testing
- contingency management and behavioral day treatment
- Volunteers
- 160 people
- Sponsor
- University of Alabama at Birmingham