Clinical trials: Cocaine Related Disorders
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Propranolol for Treatment of Cocaine Addiction - 2
The purpose of this study is to evaluate the safety and efficacy of propanolol in the early treatment of cocaine dependence.
- Trial name
- NCT00000197
- Testing
- Propranolol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues
Cocaine dependence is a chronic, relapsing disorder in which stress/negative mood and exposure to drug-related stimuli or "cues" are associated with high rates of relapse (McKay et al., 1995; O'Brien et al., 1998; R.
- Trial name
- NCT00585520
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Amphetamine-Related Disorders, Cocaine-Related Disorders
Computerized Exercise to Alter Stimulant Approach Responses
The purpose of this study is to evaluate the Computerized Exercise to Alter Stimulant Approach Responses (CEASAR), a novel stimulant use cessation intervention, for clients currently enrolled in a treatment centre for mental…
- Conditions
- Amphetamine-Related Disorders, Cocaine-Related Disorders, Substance-Related Disorders
- Trial name
- CEASAR (NCT03902405)
- Testing
- Active CEASAR Intervention
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Substance Use Disorders, Contingency Management
Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil
Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or…
- Conditions
- Substance Use Disorders, Contingency Management, Addiction, Cocaine
- Trial name
- NCT03345394
- Testing
- Contingency Management, Standard treatment
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Federal University of São Paulo
Cocaine-Related Disorders
Dopamine Reuptake Inhibitors of Cocaine Abuse - 1
The purpose of this study is to evaluate dopamine reuptake inhibitors for cocaine abuse.
- Trial name
- NCT00000276
- Testing
- Bupropion
- Where
- United States
- Sponsor
- Yale University
Cocaine, Substance Abuse
The Maternal Lifestyle Study (MLS)
This is a longitudinal, multi-site observational study of the long-term effects of a mother's use of cocaine and/or opiates during pregnancy on her infant.
- Conditions
- Cocaine, Substance Abuse, Infant, Newborn, Pregnancy
- Trial name
- MLS (NCT00059540)
- Where
- 5 sites in United States
- Volunteers
- 11,811 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Cocaine Related Disorders
Interactions Between Intravenous (IV) Cocaine and Lofexidine
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and treatment with lofexidine.
- Trial name
- NCT01148992
- Testing
- Lofexidine
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Mazindol for Cocaine Abuse - 2
The purpose of this study is to evaluate high and low dose mazindol for cocaine abuse.
- Trial name
- NCT00000277
- Testing
- Mazindol
- Where
- United States
- Sponsor
- Yale University
Methamphetamine or Cocaine Dependence
Doxazosin for Psychostimulant Dependence
Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder.
- Trial name
- NCT01371851
- Testing
- Doxazosin extended release
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arkansas
Cocaine Addiction
Vigabatrin Ph 1 Cocaine Interaction Study
This is a Phase 1 safety/tolerably study to determine if there are clinically significant interactions between oral vigabatrin (gamma vinyl-gamma-amino butyric acid; VGB) concurrent with intravenous (IV) cocaine infusions.
- Trial name
- NCT00626834
- Testing
- Vigabatrin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Opioid-Related Disorders
Combining Behavioral Treatment With Agonist Maintenance - 1
The purpose of this study is to evaluate whether the community reinforcement approach (CRA) plus contingency management (CM) is more effective overall than CRA only in reducing illicit opioid and cocaine use during agonist…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000311
- Testing
- Buprenorphine, methadone
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Yale University
Substance Abuse
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
This placebo-controlled, double-blind, randomized pilot clinical trial will evaluate atomoxetine (Strattera®) for the treatment of cocaine dependence.
- Trial name
- NCT00617201
- Testing
- atomoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Schizophrenia, Schizoaffective Disorder
Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia
It is hypothesized that the atypical antipsychotic, Seroquel, will cause significant reduction in drug and alcohol cravings in patients with schizophrenia and comorbid cocaine and/methamphetamine dependence compared to the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Abuse, Substance Dependence
- Trial name
- NCT00208143
- Testing
- Quetiapine, Risperidone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol-Related Disorders, Cocaine-Related Disorders
Interactions Between Cocaine and Ethanol and Disulfiram - 1
The purpose of this study is to assess potential interactions between intravenous cocaine and ethanol and oral disulfiram.
- Trial name
- NCT00094289
- Testing
- Disulfiram
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1
The purpose of this study is to confirm whether a blood level ""ceiling"" exists on desipramine effect in cocaine abuse.
- Trial name
- NCT00000245
- Testing
- Desipramine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the brain.
- Trial name
- NCT00134901
- Testing
- Memantine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Addiction
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence.
- Trial name
- NCT00729300
- Testing
- disulfiram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine