Clinical trials: Cocaine Related Disorders
Cocaine-Related Disorders
Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1
The purpose of this study is to assess potential interactions between intravenous (i.v.) cocaine and atomoxetine (Strattera) administered orally in four escalating doses.
- Trial name
- NCT00265265
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Opioid Dependence
Levetiracetam (Keppra) Tolerability in Cocaine Abusing Methadone-maintained Patients.
The proposed investigation will use methadone maintained patients who have concurrent cocaine dependence in order to take advantage of the excellent (over 80%) treatment retention in this patient group and to maximize treatment…
- Trial name
- Keppra (NCT00593125)
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Cocaine Dependence
Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals
Stress is associated with drug craving and relapse in substance-dependent individuals. Hormones released from the brain may mediate the behavioral response to stress.
- Trial name
- NCT01963091
- Testing
- oxytocin, saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Drug Addiction
Integration of the Therapeutic Workplace in Drug Court
Drug Courts were developed as a therapeutic alternative to incarceration of drug-involved offenders by providing 'judicially supervised' drug abuse treatment and probation for nonviolent offenders in lieu of criminal prosecution…
- Trial name
- NCT00607360
- Testing
- Therapeutic Workplace Intervention
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine-Related Disorders
The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3
Gamma-aminobutyric acid (GABA) is a type of neurotransmitter, which is a chemical that transmits information within and from the brain to all parts of the body.
- Trial name
- NCT00142883
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
Cocaine Use Disorder, Tobacco Use Disorder
Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)
This is a study of EMB-001 (a combination of two FDA-approved drugs, metyrapone and oxazepam) in otherwise healthy adults who are regular cigarette smokers.
- Trial name
- NCT02406066
- Testing
- metyrapone & oxazepam
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Embera NeuroTherapeutics, Inc.
Cocaine Dependence, Alcohol Dependence
VIVITROL as a Treatment for Cocaine and Alcohol Dependence
To evaluate the efficacy of VIVITROL (naltrexone for extended-release injectable suspension) for the treatment of co-occurring cocaine and alcohol dependence
- Trial name
- NCT00777062
- Testing
- VIVITROL (Naltrexone extended-release injectable suspension)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence, Opioid Dependency
Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients
Concurrent dependence on cocaine occurs in up to 50% of the over one million opiate dependent patients in spite of methadone maintenance treatment being highly effective for opiate dependence and having excellent treatment…
- Trial name
- Keppra-DB (NCT00577005)
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Opioid-use Disorder, Cocaine Use Disorder
Feasibility and Validation of a Standard Phenotyping Assessment Battery
The overall goal of this project is to collect preliminary data on psychosocial measures and behavioral performance comparing individuals with Opioid Use Disorder, Cocaine Use Disorder, dual diagnosis of Opioid and Cocaine Use…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Marijuana Use Disorder, Healthy Controls
- Trial name
- PhAB (NCT03495869)
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence
The study aims to evaluate the safety and efficacy of modafinil (200 mg/day) over 10 weeks plus a tailored cognitive behavioural therapy program in the treatment of cocaine dependence.
- Trial name
- NCT00123383
- Testing
- Modafinil
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- The University of New South Wales
Cocaine-Related Disorders, Substance-Related Disorders
A Study of Cabergoline for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess cabergoline for the Treatment of Cocaine Dependence
- Trial name
- NCT00033111
- Testing
- Cabergoline
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Developing Adaptive Interventions for Cocaine Cessation and Relapse Prevention
First, the investigators will determine whether Acceptance and Commitment Therapy in combination with Contingency Management increases initial treatment response rates.
- Trial name
- NCT02896712
- Testing
- Acceptance and Commitment Therapy (ACT), Drug Counseling (DC), Contingency Management (CM)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Abuse, Cocaine-Related Disorders
Progesterone for the Treatment of Cocaine Dependence - 1
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high.
- Trial name
- NCT00218257
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota
Cocaine Dependence, Cocaine Addiction
Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study
The main purpose of this study is to determine if it is safe to use the study drug, clavulanic acid, in combination with cocaine.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
- Trial name
- NCT02563769
- Testing
- Clavulanic acid, Intravenous cocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Temple University
Cognitive Dysfunction, Stimulant Use
Change in Cognitive Function in Stimulant Users
In Hong Kong, methamphetamine use is common and cocaine use has increased steadily over the past few years. While the use of ketamine decreased from 35.8% in 2015 to 13.9% in 2017, methamphetamine and cocaine have become the most…
- Conditions
- Cognitive Dysfunction, Stimulant Use, Methamphetamine Abuse, Cocaine Use
- Trial name
- SToP-S_CogFx (NCT04061941)
- Testing
- Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 93 people
- Sponsor
- The University of Hong Kong
Bipolar Disorder, Cocaine Dependence
Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency
The purpose of this study is to determine if lamotrigine add-on therapy is associated with decreased cocaine craving and improvement in depressive symptom severity than placebo in a group of outpatients with bipolar disorder and…
- Trial name
- NCT00280293
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine Dependence
Investigation of Mifepristone (RU486) on Stress Sensitivity and Relapse Prevention in Cocaine Dependent Patients
This research will evaluate the impact of blocking central and peripheral glucocorticoid receptors on stress sensitivity and the risk of relapse to cocaine use in treatment-seeking cocaine-dependent individuals.
- Trial name
- NCT01134198
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Modafinil, a medication that enhances mood, increases energy, and improves concentration, may be useful in preventing…
- Trial name
- NCT00218387
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Substance-Related Disorders
Quetiapine for Cocaine Use and Cravings
The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals.
- Trial name
- NCT00232336
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Cocaine Dependence
A Study of Baclofen ER
This is a Phase II, randomized, double-blind, placebo-controlled study that will examine the efficacy of extended-release baclofen (Baclofen ER) for the treatment of cocaine dependence.
- Trial name
- CURE (NCT02003664)
- Testing
- Baclofen ER
- Where
- United States
- Sponsor
- University of Pennsylvania