Clinical trials: Cocaine Related Disorders
Neural Systems, Drug Abuse
PET Assays of Striatal Dopamine Marker in Cocaine Craving
Background: Cues related to past drug use induce a particular pattern of brain activation, which has been correlated with craving for cocaine in active cocaine abusers.
- Conditions
- Neural Systems, Drug Abuse, Cocaine Dependence
- Trial name
- NCT01036516
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction
Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder
Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction.
- Trial name
- NCT03025321
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- Erasmus Medical Center
HIV, Drug Addiction
Treating South African Pregnant Women for Methamphetamine
The purpose of this study was to develop and initially evaluate an efficacious, comprehensive, culturally sensitive, women-centered model of care for pregnant South African women by adapting and refining PI Jones'…
- Trial name
- NCT01386138
- Testing
- Psycho-education, Experimental
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- RTI International
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine Use Disorder
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
The purpose of this study is to assess effects of intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham on electrophysiological…
- Trial name
- NCT05986578
- Testing
- TMS to dmPFC, TMS to dlPFC
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts.
- Trial name
- NCT03471182
- Testing
- Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence
Effectiveness of Extended Treatments for Drug Dependence
This study tests the effectiveness of two 24 month, telephone-based adaptive continuing care interventions for patients with cocaine dependence.
- Trial name
- ETDD (NCT00685659)
- Testing
- Intensive Outpatient Treatment, Adaptive telephone-based counseling, Adaptive telephone-based counseling plus incentives
- Where
- 2 sites in United States
- Volunteers
- 332 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders, Substance-Related Disorders
Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11
The purpose of this study is to evaluate PET methodology to study in vivo synaptic dopamine release.
- Trial name
- NCT00015301
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction
Efficacy of N-acetylcysteine on the Craving Symptoms of Abstinent Hospitalized Patients With Cocaine Addiction
Cocaine abuse is associated with serious physical, psychiatric and social problems. Addiction results in the compulsive use of a substance with loss of control and persistence despite the negative consequences.The act of…
- Trial name
- NCT03423667
- Testing
- N-acetylcysteine, Lactose powder
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Salvatore Campanella
Cocaine-Related Disorders
Modafinil for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of modafinil in reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT00100100
- Testing
- Modafinil
- Where
- 6 sites in United States
- Volunteers
- 210 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000316
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
ADHD, Opioid-Related Disorders
Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
The purpose of this study is to treat Adult Attention Deficit Hyperactivity Disorder (ADHD) in methadone patients.
- Conditions
- ADHD, Opioid-Related Disorders, Cocaine Dependence
- Trial name
- NCT00061087
- Testing
- Methylphenidate, Bupropion
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorders
D-Cycloserine Facilitation of Cocaine - Cue Extinction
The purpose of this study is to explore the use of d-cycloserine (DCS) to facilitate extinction of response to cocaine cues in cocaine-dependent individuals, in hopes that it may lead to the development of new treatment options…
- Trial name
- NCT00759473
- Testing
- D-Cycloserine (DCS)
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000210
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Tryptophan and Behavior Therapy for Cocaine Abuse - 1
The purpose of this study is to assess the efficacy of tryptophan vs. placebo, and voucher payments vs. a control condition, in the treatment of cocaine dependence.
- Trial name
- NCT00000324
- Testing
- Tryptophan
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Behavior, Addictive
The Effectiveness of a Brief Motivational Nursing Intervention
This was a two-staged study undertaken in entertainment-sector workers in Spain: the first part was transversal and observational, and the second was semi-experimental.
- Trial name
- BMNI (NCT04125303)
- Testing
- brief motivational psychoeducational therapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Cocaine Dependence, in Remission, Cocaine Abuse, in Remission
Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid
The main purpose of this study is to determine how the study drug, clavulanic acid, affects glutamate in the brain using Magnetic Resonance (MR/MRI) scans.
- Conditions
- Cocaine Dependence, in Remission, Cocaine Abuse, in Remission, Cocaine-Related Disorders
- Trial name
- CLAVMRPilot (NCT03986762)
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Temple University
Cocaine-Related Disorders
Acoustic Startle Reduction In Cocaine Dependence
Chronic cocaine administration leads to changes in brain function that persist long after the acute withdrawal phase. The acoustic startle response (ASR) is a well characterized reflexive response to a sudden acoustic stimulus.
- Trial name
- NCT00430690
- Testing
- acoustic startle testing
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Emory University
Cocaine Abuse and Dependence
Use of Donepezil for Treatment of Cocaine Dependence
The purpose of this study is to determine the safety of intravenous cocaine in subjects receiving oral donepezil.
- Trial name
- NCT00467389
- Testing
- Donepezil, 5 mg daily
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Cocaine Addiction
Integrative Meditation (IM) for Cocaine Addiction
Cocaine addiction continues to be a major problem in the U.S. with no FDA-approved pharmaceutical therapy. Finding effective treatment for cocaine addiction has long been a challenge to scientists and clinicians.
- Trial name
- NCT01211418
- Testing
- Integrative Meditation, Supportive Counseling
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Maryland, Baltimore