Clinical trials: Cocaine Related Disorders
Cocaine Related Disorders
Stress and Medication Effects on Cocaine Cue Reactivity
Stressful situations and cues associated with cocaine can lead to craving in cocaine dependent individuals. The purpose of this study is to determine whether guanfacine or modafinil are effective in reducing stress and cue…
- Trial name
- NCT00613015
- Testing
- Guanfacine, Modafinil
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Medical University of South Carolina
Cocaine Related Disorders
The Effect of Yohimbine on Cocaine Cue Reactivity
Stress and cues reminiscent of cocaine use promote craving and relapse in cocaine dependent individuals. In addition, there appears to be gender differences in determinants of relapse to drug use following abstinence in…
- Trial name
- NCT00535002
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcoholism, Cocaine Dependence
Topiramate for Alcohol and Cocaine Dependence
The primary purpose of this study is to test the effectiveness of topiramate for the treatment of combined alcohol and cocaine dependence. Topiramate is approved for the treatment of seizures.
- Trial name
- TOP2 (NCT00167245)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Kyle Kampman
Cocaine Abuse
Effects of Aripiprazole on Cocaine Craving and Self-Administration
The purpose of this study is to investigate whether aripiprazole will decrease cocaine self-administration, subjective effects and cravings compared to placebo.
- Trial name
- NCT00373880
- Testing
- Aripiprazole + Cocaine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Substance Abuse Disorder
Brain Imaging Studies of the Effects of Cocaine Abstinence
This study evaluates theories regarding cocaine abstinence which propose that increased presynaptic and postsynaptic dopamine activity and increased serotonin activity are associated with abstinence in cocaine dependent subjects…
- Trial name
- NCT00581282
- Testing
- PET scan, fMRI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cocaine-Related Disorders
Cocaine Abuse and Attention Deficit Disorder - 3
The purpose of this study is to evaluate cocaine abuse and Attention Deficit Disorder
- Trial name
- NCT00000268
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Aripiprazole to Reduce Cocaine Relapse
Despite the many behavioral and cognitive treatment therapies that exist for cocaine addiction, individuals who complete cocaine abuse treatment are still at high risk for relapsing.
- Trial name
- NCT00276874
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Craig Rush
Cocaine Dependence
Brain Function and Structure in Cocaine Dependence
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
- Trial name
- NCT02080832
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders, Substance-Related Disorders
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1
The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in cocaine treatment; an evaluation of the ""replacement"" strategy.
- Trial name
- NCT00000304
- Testing
- Dextroamphetamine, D-Amphetamine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
M-CPP and Fenfluramine in Cocaine Addicts - 3
The purpose of this study is to evaluate predictive value of M-CPP and fenfluramine challenges for outcome.
- Trial name
- NCT00000314
- Testing
- M-CPP
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence
Cocaine dependence is a major public health problem and the development of a treatment for this disorder is a priority. To date, treatment interventions based on positive incentive principles have shown the strongest effects for…
- Trial name
- NCT00713583
- Testing
- levodopa, Cognitive Behavioral Therapy, Contingency Management
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence, in Remission
AAV8-hCocH for Cocaine Use Disorder
The purpose of this study is to test the safety of a novel gene viral vector treatment for adults with cocaine use disorder-sustained remission.
- Trial name
- NCT04884594
- Testing
- AAV8-hCocH
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- W. Michael Hooten
Cocaine-Related Disorders
Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine
Cocaine abuse continues to represent a significant public-health concern. Cocaine likely creates its addictive effects by increasing levels of dopamine, a chemical found in the brain.
- Trial name
- NCT00218166
- Testing
- GABA Agonists
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
New Approaches to Cocaine Abuse Medications (A) - 6
The purpose of this study is to measure the effect of desipramine in cocaine abusers selected for major depression or dysthymia.
- Trial name
- NCT00000271
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Clinical Trial of Topiramate for Cocaine Addiction
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment.
- Trial name
- NCT00685178
- Testing
- topiramate, Contingency Reinforcement
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse…
- Trial name
- PET-CRA (NCT00376558)
- Testing
- Community Reinforcement Approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Baclofen for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of baclofen for the treatment of cocaine dependence.
- Trial name
- NCT00082485
- Testing
- Baclofen
- Where
- 8 sites in United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the treatment of cocaine dependence using reserpine, gabapentin, or lamotrigine vs. an unmatched placebo control.
- Trial name
- NCT00015106
- Testing
- Lamotrigine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Gender and Neural Substrates of Stress and Craving
Cocaine dependence is an insidious disease underscored by a powerful proclivity to relapse despite an individual's ability to recognize the deleterious consequences of continued drug use.
- Trial name
- NCT00756925
- Testing
- Acthrel
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Carbamazepine Treatment for Cocaine Dependence - 5
The purpose of this study is to assess carbamazepine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000191
- Testing
- Carbamazepine
- Where
- United States
- Sponsor
- University of Pennsylvania