Clinical trials: Cocaine Related Disorders
Cocaine Use Disorders
D-Cycloserine Facilitation of Cocaine - Cue Extinction
The purpose of this study is to explore the use of d-cycloserine (DCS) to facilitate extinction of response to cocaine cues in cocaine-dependent individuals, in hopes that it may lead to the development of new treatment options…
- Trial name
- NCT00759473
- Testing
- D-Cycloserine (DCS)
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence, Opiate Dependence
Cocaine Withdrawal and Pharmacotherapy Response
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day)…
- Trial name
- Carvedilol (NCT00566969)
- Testing
- sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the brain.
- Trial name
- NCT00134901
- Testing
- Memantine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse…
- Trial name
- NCT01535937
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Related Disorders
Stress and Medication Effects on Cocaine Cue Reactivity
Stressful situations and cues associated with cocaine can lead to craving in cocaine dependent individuals. The purpose of this study is to determine whether guanfacine or modafinil are effective in reducing stress and cue…
- Trial name
- NCT00613015
- Testing
- Guanfacine, Modafinil
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.
This proposal describes a combined laboratory and clinical trial preliminary investigation to advance medication development for cocaine dependence.
- Trial name
- NCT02255357
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorder, Methamphetamine Abuse
rTMS for Stimulant Use Disorders
The purpose of the study is to determine feasibility of repetitive transcranial magnetic stimulation (rTMS) for individuals with moderate to severe cocaine or methamphetamine use disorder (CUD/MUD).
- Conditions
- Cocaine Use Disorder, Methamphetamine Abuse, Cocaine Dependence, Methamphetamine Dependence
- Trial name
- CTN-0108 (NCT04907357)
- Testing
- rTMS
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Medical University of South Carolina
Cocaine Addiction, Cocaine-related Disorder
Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
The use of crack-cocaine is growing at alarming rate in our country and it is absolutely worrisome the fast establishment of addiction to it.
- Conditions
- Cocaine Addiction, Cocaine-related Disorder, Executive Dysfunction
- Trial name
- NCT01337297
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Espirito Santo
Cocaine Dependence
Cognitive Remediation for Cocaine Dependence
The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.
- Trial name
- NCT01393457
- Testing
- levodopa/carbidopa, Ropinirole 2 mg/d, Ropinirole 4 mg/d
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence
Glutamatergic Modulation of Cocaine-related Deficits
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
- Trial name
- NCT01790490
- Testing
- Ketamine 0.41 mg/kg, Ketamine 0.71 mg/kg, Lorazepam 2 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Cocaine Dependence
Chantix for Treating Cocaine Dependence
The purpose of this study is to determine whether varenicline (Chantix), is effective for the treatment of cocaine dependence.
- Trial name
- NCT00567008
- Testing
- varenicline
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Modafinil, a medication that enhances mood, increases energy, and improves concentration, may be useful in preventing…
- Trial name
- NCT00218387
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders, Contingency Management
Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil
Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or…
- Conditions
- Substance Use Disorders, Contingency Management, Addiction, Cocaine
- Trial name
- NCT03345394
- Testing
- Contingency Management, Standard treatment
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Federal University of São Paulo