Clinical trials: Cocaine Related Disorders
Cocaine-Related Disorders
Evaluation of N-Acetylcysteine Efficacy to Reduce the Craving and to Prolong Abstinence Time of Coca Paste
Introduction: The Cocaine Base Paste (or Coca Paste or CBP), a highly toxic and addictive smokable drug (a by-product of the cocaine extraction chain), has become in the last years a real social scourge for Chile.
- Trial name
- NAC-PBC (NCT03556371)
- Testing
- N-Acetylcysteine
- Where
- 5 sites in Chile
- Volunteers
- 140 people
- Sponsor
- University of Concepcion, Chile
Cocaine Addiction
Developing Computer Based Treatments for Addiction
The purpose of our research is to examine the promise of a new computer based approach to use in usual drug counseling when treating crack cocaine addiction.
- Trial name
- NCT00586534
- Testing
- I/GDC + VR/CER, I/GDC
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Duke University
Cocaine Dependence
A Placebo-Controlled Double-Blind Combined Treatment of Modafinil and CBT for Cocaine Dependence
The purpose of this study is to test whether a cognitive behavioral therapy (CBT) and a medication called modafinil, which is approved to treat sleep disorders, will help individuals who are abusing cocaine.
- Trial name
- NCT00344565
- Testing
- Modafinil, Cognitive Behavioral Therapy--Relapse Prevention
- Volunteers
- 15 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Pre-natal Cocaine Exposure, Risk-Taking
Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults
Reward processing will be examined in prenatally exposed emerging adults in a longitudinal design. Participants will be followed for one year to see if neural markers of reward processing prospectively predict risk-taking…
- Trial name
- NCT03268759
- Testing
- fMRI
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Use Disorders
D-Cycloserine and Cue Exposure in Cocaine-Dependent Individuals
In summary, this pilot study will explore the use of an innovative pharmacologic approach to the treatment of substance dependence through the facilitation of extinction of response to cocaine-conditioned cues in…
- Trial name
- NCT00780442
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Pemoline for Cocaine Abuse - 7
The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse.
- Trial name
- NCT00000282
- Testing
- Pemoline
- Where
- United States
- Sponsor
- Yale University
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cocaine Dependence
Modafinil, Sleep Architecture and Cocaine Relapse
The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users.
- Trial name
- NCT01137396
- Testing
- Modafinil, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Yale University
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218062
- Testing
- D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Withdrawal, Cocaine Smoking
Use of Intranasal Oxytocin During Detoxification of Crack Cocaine
This study investigated whether adding oxytocin nasal spray to usual inpatient treatment could reduce withdrawal, anxiety, and depressive symptoms in women hospitalized for cocaine detoxification.
- Conditions
- Cocaine Withdrawal, Cocaine Smoking, Cocaine-Related Disorders
- Trial name
- NCT04306354
- Testing
- Oxytocin nasal spray, Conventional Inpatient Treatment
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Cocaine Dependence, Healthy
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS
This study is designed to look at the relationship between brain glucose utilization, neurotransmission (e.g., glutamate, also known as the main excitatory amino-acid neurotransmitter in the brain), and synaptic density.
- Trial name
- NCT02124941
- Testing
- N-acetyl cysteine, [18F]FDG PET scan, 1H MRS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Cocaine Use Disorder, Methamphetamine Abuse
rTMS for Stimulant Use Disorders
The purpose of the study is to determine feasibility of repetitive transcranial magnetic stimulation (rTMS) for individuals with moderate to severe cocaine or methamphetamine use disorder (CUD/MUD).
- Conditions
- Cocaine Use Disorder, Methamphetamine Abuse, Cocaine Dependence, Methamphetamine Dependence
- Trial name
- CTN-0108 (NCT04907357)
- Testing
- rTMS
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Anhedonia
Targeting Anhedonia in Cocaine Use Disorder
The purpose of this study is to examine anhedonia as a potential moderator of treatment outcomes for Cocaine Use Disorder (CUD).
- Trial name
- NCT02773212
- Testing
- d-amphetamine, Contingency management
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Illinois Chicago
Cocaine Addiction, Cocaine Dependence
Vigabatrin for the Treatment of Cocaine Dependency
The objective of this 26-28 week study is to demonstrate that the rate of cocaine dependent subjects treated with CPP-109 vigabatrin in addition to counseling, who completely stop use of cocaine in the last 2 weeks of the study's…
- Trial name
- NCT01281202
- Testing
- Vigabatrin
- Where
- 13 sites in United States
- Volunteers
- 207 people
- Sponsor
- Catalyst Pharmaceuticals, Inc.
Cocaine Dependence
Behavioral Treatment for Cocaine Dependent Women
To compare the efficacy of Community Reinforcement Approach (CRA) and 12-Step Facilitation (TSF) counseling and of voucher based reward therapy (VBRT) and a yoked, non-contingent voucher control (VC) for the treatment of cocaine…
- Trial name
- NCT00914381
- Testing
- Behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 145 people
- Sponsor
- Yale University
Cocaine-related Disorder
Study to Investigate Whether AFQ056 Reduces Cocaine Use in Patients Diagnosed With Cocaine Use Disorder (CUD)
This study assessed whether AFQ056 had a beneficial effect by reducing cocaine use in Cocaine Use Disorder (CUD) patients as assessed by Timeline Follow-Back cocaine self-report.
- Trial name
- NCT03242928
- Testing
- AFQ056
- Where
- 8 sites in Argentina, Spain and 1 more
- Volunteers
- 68 people
- Sponsor
- Novartis Pharmaceuticals
Cocaine Abuse
Prize Contingency Management for Cocaine-Dependent Methadone Patients
The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and…
- Trial name
- NCT01401270
- Testing
- prize contingency management
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- UConn Health
Cocaine-Related Disorders, Substance-Related Disorders
Pergolide Treatment for Substance Abusers - 4
The purpose of this study is to evaluate the safety and efficacy of pergolide for cocaine dependence.
- Trial name
- NCT00000269
- Testing
- Pergolide
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)