Clinical trials: Cocaine Use Disorder, open to volunteers
Cocaine Use Disorder (CUD), Cognitive Impairments
The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users
The study aims to address the neurobiological basis of cognitive impairments in chronic cocaine users by investigating the potential impact of an acute potassium channel blockade on working memory performance and other cognitive…
- Trial name
- POTCHICUD (NCT07532460)
- Testing
- 4-aminopyridine (4-AP)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Boris Quednow
Cocaine Use Disorder
Impact of Cocaine Use and Withdrawal on Sleep
This study investigates how cocaine use and withdrawal affect sleep and circadian rhythms in individuals undergoing inpatient detoxification.
- Trial name
- CokeSo (NCT07119567)
- Testing
- Multimodal Sleep and Biomarker Assessment
- Where
- 3 sites in France
- Volunteers
- 32 people
- Sponsor
- Hôpital le Vinatier
Cocaine Use Disorder (CUD)
Examination of Transcranial Focused Ultrasound on Brain Activity in Adults With Cocaine Use Disorder
The investigators aim to examine the effect of transcranial focused ultrasound (tFUS) on brain activity and cocaine craving in adults with cocaine use disorder.
- Trial name
- NCT07852923
- Testing
- tFUS
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Mary Phillips, MD MD (Cantab)
Cocaine Use Disorder, Cocaine Dependence
Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder.
- Trial name
- Co-Boost (NCT06125054)
- Testing
- Ketamine, real-time fMRI neurofeedback training
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Marcus Herdener
Stimulant Use Disorder
Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
The purpose of this study is to determine the effects of suvorexant (SUVO), on sleep, stress, and drug craving during early abstinence from stimulants and to determine the effects of treatment (SUVO vs.
- Trial name
- NCT06444256
- Testing
- SUVO, TAU
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Use Disorder
Imaging CRF X NOP Interactions in CUD
This study uses [11C]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in…
- Trial name
- NCT05008146
- Testing
- Baseline [C-11]NOP-1A PET Scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET Scan
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Stimulant Use Disorder
Smartphone Services for Stimulant Use Disorder
This study is testing two approaches to treating Stimulant Use Disorder, or problems with cocaine, crack, methamphetamine, etc. Stimulant Use Disorder is a national epidemic in the U.S.
- Trial name
- NCT07092059
- Testing
- Smartphone digital therapeutic system
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- DynamiCare Health
Stimulant Use Disorder, Cocaine Use Disorder
LDART for Stimulant Use Disorder
The goal of this study is to evaluate the feasibility, acceptability, and preliminary efficacy of a digital intervention called LDART in adults with stimulant use disorder.
- Conditions
- Stimulant Use Disorder, Cocaine Use Disorder, Methamphetamine Use Disorder
- Trial name
- LDART (NCT07221396)
- Testing
- LDART, Psychoeducational booklet
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Cocaine Dependence
Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function.
- Trial name
- NCT06189690
- Testing
- rTMS
- Where
- Mexico
- Volunteers
- 102 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine Use Disorder
CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations
This research focuses on behavioral sensitization (BS) a specific behavioural disturbance in crack-cocaine addiction. The primary objective is to observe whether BS can be demonstrated in an ecological setting in crack dependent…
- Trial name
- CRACK-TARGET (NCT06050304)
- Testing
- Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter, 3 blood tests
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cocaine Use Disorder
Open-label Feasibility Trial of HD-tDCS During Cognitive Behavioral Therapy for Cocaine Use Disorder
Cocaine Use Disorder (CocUD) is a significant public health issue with increasing cocaine-related overdose mortality. Effective treatments for CocUD are highly needed.
- Trial name
- NCT07829263
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Virginia Commonwealth University
Crack Cocaine Use
NEUROphysiology of CRACK Use Disorder in ITaly
The goal of this randomized clinical trial is to verify if a Scott-Kaiser neurofeedback protocol can improve inhibitory control, reduce craving, and enhance treatment adherence in individuals with crack cocaine use disorder.
- Trial name
- NEURO-CRACK-IT (NCT07735923)
- Testing
- EEG-Biofeedback - Scott-Kaiser Protocol
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Cocaine Use Disorder, Cocaine Dependence
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder or opioid use disorder.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder
- Trial name
- NCT07318480
- Testing
- Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine Use Disorder
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD).
- Trial name
- NCT05011760
- Testing
- Baseline [C-11]NPA PET Scan, d-amphetamine, Post-amphetamine [C-11]NPA PET Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rajesh Narendran
Cocaine Use Disorder, Healthy Controls Group - Age and Sex-matched
Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study
Studies proposed in this application will image mitochondrial Complex-I in cocaine use disorder (CUD) and matched healthy controls
- Trial name
- NCT07773649
- Testing
- [F-18]BCPP-EF
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Cocaine Use Disorder
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
The purpose of this study is to evaluate semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in combination with cognitive behavioral therapy (CBT) for the treatment of cocaine use disorder (CUD).
- Trial name
- NCT07227948
- Testing
- Semaglutide, cognitive behavioral therapy (CBT).
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern
Cocaine Use Disorder (CUD)
Contingency Management Plus Deep Transcranial Magnetic Stimulation for the Treatment of Cocaine Use Disorder
The purpose of this study is to evaluate the effects of Contingency Management (CM)+transcranial magnetic stimulation (TMS) on treatment outcomes in individuals who are initial non-responders and to evaluate the effects of CM+TMS…
- Trial name
- NCT07490600
- Testing
- Contingency Management (CM), Transcranial Magnetic Stimulation (TMS) experimental
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Use Disorder
Cocaine Cue-reactivity Incubation Study
In this study, the research team proposes to longitudinally assess incubation of cue-reactivity, its reduction with cognitive reappraisal (CR; a self-regulation technique) and examine the impact of CR on clinical outcomes in…
- Trial name
- NCT07091877
- Testing
- Cognitive Reappraisal, Control cue-reactivity task
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Icahn School of Medicine at Mount Sinai