Clinical trials: Cocaine-Related Disorders
Cocaine-Related Disorders
Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1
Although a great amount of research has been conducted to resolve cocaine dependence, an effective treatment has yet to be discovered. Topiramate is a drug that was found to be useful in treating alcohol dependence.
- Trial name
- NCT00249691
- Testing
- Topiramate + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bankole Johnson
Cocaine-Related Disorders
Effects of Labetalol on Human Cocaine Use - 8
The purpose of this study is to determine the effect of labetalol treatment on the subjective and physiological effects of cocaine.
- Trial name
- NCT00000291
- Testing
- Labetalol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence, Cocaine Dependence
Novel Pharmacotherapy for Dual Dependence
The purpose of this study is to evaluate the effects of Topiramate and Cognitive Behavioral Therapy for the treatment of alcohol and cocaine dependence.
- Trial name
- NCT00448825
- Testing
- Topiramate + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bankole Johnson
Cocaine-related Disorders
Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT…
- Trial name
- NCT00877435
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Cocaine Dependence
A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
The purpose of this study is to see if a drug called Candesartan will help to reduce use of cocaine.
- Trial name
- NCT01938664
- Testing
- Candesartan with CBT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Modafinil Treatment for Cocaine-Dependent Individuals
Despite years of active research, there are still no approved medications for the treatment of cocaine dependence. The purpose of this study is to determine the effectiveness of modafinil in treating cocaine-dependent individuals.
- Trial name
- NCT00129285
- Testing
- Low Dose Modafinil, High Dose Modafinil
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Cocaine Dependence
Brain Function and Structure in Cocaine Dependence
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
- Trial name
- NCT02080832
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Virginia Commonwealth University
Cocaine Use Disorder
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive…
- Trial name
- NCT05529927
- Testing
- Sustained-release Dexamphetamine
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Parnassia Addiction Research Centre
Substance Use Disorders, Opioid Use Disorder
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
The overarching goal of this study phase, Phase II component is to implement Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR) device in substance use disorder (SUD)…
- Conditions
- Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder
- Trial name
- EDITOR (NCT06434818)
- Testing
- EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Evon Medics LLC
Cocaine Dependence
The Efficacy of Doxazosin for Cocaine Users
Doxazosin, an alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine dependent participants.
- Trial name
- NCT00880997
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Pemoline for Cocaine Abuse - 7
The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse.
- Trial name
- NCT00000282
- Testing
- Pemoline
- Where
- United States
- Sponsor
- Yale University
Bipolar Disorder, Cocaine Dependence
Valproate Efficacy in Cocaine-Bipolar Comorbidity
This proposal will test the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder.
- Trial name
- NCT00240110
- Testing
- Valproate, Lithium Carbonate
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cocaine Addiction
Developing Computer Based Treatments for Addiction
The purpose of our research is to examine the promise of a new computer based approach to use in usual drug counseling when treating crack cocaine addiction.
- Trial name
- NCT00586534
- Testing
- I/GDC + VR/CER, I/GDC
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Duke University
Substance-Related Disorders
Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder
This is a randomized, double-blind, placebo-controlled phase 2b pilot clinical trial to determine whether non-ergoline D3/D2/D1 dopamine (DA) receptor agonist rotigotine (RTG), in combination with treatment as usual, including…
- Trial name
- NCT05886582
- Testing
- Rotigotine Transdermal System [Neupro]
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 2
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000211
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cocaine Addiction
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
The purpose of this study is to determine the safety and effects of rivastigmine and huperzine A (HupA), potential treatments for cocaine abuse, when used before experimental administration of cocaine, on a number of physical and…
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01030692
- Testing
- Rivastigmine 3 mg, Huperzine A 0.4 mg, Rivastigmine 6 mg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Cocaine Addiction
Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder
Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction.
- Trial name
- NCT03025321
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- Erasmus Medical Center
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine Use Disorder, Cocaine Dependence
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
- Trial name
- NCT05857852
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Virginia