Clinical trials: Cocaine-related Disorders
Cocaine Dependence, Cocaine Addiction
Exercise as a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to test the effects of exercise on cocaine use, fitness, and cravings for cocaine and nicotine. This study is part of an effort to develop treatments for cocaine abuse.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01601743
- Testing
- Sitting, Running, Walking
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Cocaine Dependence, Depressive Disorder, Major
Integrated Treatment for Cocaine and Mood Disorders - 1
The purpose of this study is to test whether cognitive behavioral therapy and bupropion hydrochloride will help cocaine users, who are depressed, reduce or end their cocaine use and improve their mood.
- Trial name
- NCT00227812
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cannabis Dependence
Risk Perception in Drug-Dependent Adults With and Without Schizophrenia
Background: Several studies of risk perception have demonstrated a common bias known as unrealistic optimism, in which individuals feel they are less likely than other people to experience unpleasant or harmful events in their…
- Conditions
- Cocaine Dependence, Cannabis Dependence, Schizophrenia
- Trial name
- NCT01031563
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Interaction Between Cocaine and Quetiapine - 1
The purpose of this study is to assess the safety of intravenous (IV) cocaine in subjects taking quetiapine at 3 dosage levels.
- Trial name
- NCT00087750
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.
- Trial name
- NCT00100113
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Neurocircuit Strategy to Decrease Cocaine Cue Reactivity
The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.
- Trial name
- COCA (NCT04155632)
- Testing
- N-acetylcysteine, Theta-burst stimulation (TBS)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
High Dose Nimodipine Treatment Adjunct - 1
The purpose of this study is to determine if nimodipine is more effective than placebo in reducing stimulated craving for cocaine in cocaine dependent individuals denied access to cocaine in inpatient unit.
- Trial name
- NCT00000332
- Testing
- Nimodipine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals
Preliminary research has shown that venlafaxine, a medication currently used for treating depression, may also discourage cocaine use in depressed individuals.
- Trial name
- NCT00249483
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Treatment of Cocaine Dependence With Lisdexamfetamine
This protocol is a 2-group double-blind placebo-controlled outpatient study investigating lisdexamfetamine for treatment of cocaine dependence. The investigators plan to enroll 100 subjects in a 14-week trial.
- Trial name
- NCT00958282
- Testing
- lisdexamfetamine/Behavior Therapy
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Cocaine Dependence
Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence
The primary objective of this study is to assess the efficacy of vigabatrin for the treatment of cocaine dependence, based on the twice-weekly qualitative urine toxicologies for cocaine.
- Trial name
- NCT00527683
- Testing
- Vigabatrin, Group therapy
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cocaine Dependence
Impulsivity, Neural Deficits and Cocaine Addiction
The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of…
- Trial name
- NCT00744601
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Opioid Use Disorder, Cocaine Use Disorder
Cocaine Opioid Oxytocin Option - Limited
This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.
- Trial name
- COOOL (NCT02028533)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Alcohol-Related Disorders, Cocaine-Related Disorders
Disulfiram for Cocaine-Alcohol Abuse - 3
The purpose of this study is to evaluate disulfiram for cocaine-alcohol abuse.
- Trial name
- NCT00000278
- Testing
- Disulfiram
- Where
- United States
- Sponsor
- Yale University
Cocaine Dependence
Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid
A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
- Trial name
- NCT04411914
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Temple University
Cocaine-Related Disorders
Dextroamphetamine-Cocaine Behavioral Intervention - 5
The purpose of this study is to examine dextroamphetamine-cocaine behavioral intervention in cocaine dependent patients.
- Trial name
- NCT00000308
- Testing
- Dextroamphetamine, D-amphetamine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Psychostimulant Abuse - Novel Treatment Approaches - 1
To determine if acute assessments of profasi and factrel affect plasma cocaine levels and cocaine-induced behavioral changes in men.
- Trial name
- NCT00000325
- Testing
- Gonadorelin
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.
- Trial name
- NCT00032929
- Testing
- Selegiline
- Where
- 16 sites in United States
- Volunteers
- 269 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1
The purpose of this study is to confirm whether a blood level ""ceiling"" exists on desipramine effect in cocaine abuse.
- Trial name
- NCT00000245
- Testing
- Desipramine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)