Clinical trials: Cocaine-related Disorders
Cocaine Dependence, Cannabis Dependence
Risk Perception in Drug-Dependent Adults With and Without Schizophrenia
Background: Several studies of risk perception have demonstrated a common bias known as unrealistic optimism, in which individuals feel they are less likely than other people to experience unpleasant or harmful events in their…
- Conditions
- Cocaine Dependence, Cannabis Dependence, Schizophrenia
- Trial name
- NCT01031563
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000316
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Modafinil, a medication that enhances mood, increases energy, and improves concentration, may be useful in preventing…
- Trial name
- NCT00218387
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Piracetam for Treatment of Cocaine Addiction - 3
The purpose of this study is to evaluate the effects of IV cocaine administration in cocaine dependent subjects maintained on piracetam while they are residing in an inpatient addictions treatment research unit and to…
- Trial name
- NCT00000198
- Testing
- Piracetam
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Cocaine Abuse and ADHD - 10
The purpose of this study is to evaluate the safety and efficacy of buproprion in treating individuals with adult attention-deficit hyperactivity disorder (ADHD) and cocaine dependence.
- Trial name
- NCT00000275
- Testing
- Flupenthixol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Cocaine-Related Disorders, Substance-Related Disorders
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1
The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in cocaine treatment; an evaluation of the ""replacement"" strategy.
- Trial name
- NCT00000304
- Testing
- Dextroamphetamine, D-Amphetamine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Dose Response Trial of Pergolide for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.
- Trial name
- NCT00000248
- Testing
- Pergolide
- Where
- United States
- Sponsor
- Medical University of South Carolina
Cocaine Use Disorder
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
The purpose of this study is to assess effects of intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham on electrophysiological…
- Trial name
- NCT05986578
- Testing
- TMS to dmPFC, TMS to dlPFC
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Agonist Replacement Therapy for Cocaine Dependence
Cocaine dependence is a significant public health concern. The proposed research will provide important clinical information regarding the efficacy of agonists replacement therapies for managing cocaine dependence.
- Trial name
- NCT00697138
- Testing
- d-Amphetamine; Atomoxetine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Kentucky
Cocaine-Related Disorders, Substance-Related Disorders
Reserpine for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of reserpine for the treatment of cocaine dependence.
- Trial name
- NCT00033033
- Testing
- Reserpine
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Addiction, Opioid Dependence
Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction
The purpose of this study is determine the safety, efficacy and tolerability of a novel drug APH-1501 as a pharmacotherapy for Opioid Dependence. The investigators will evaluate the safety of escalating doses APH-1501.
- Conditions
- Addiction, Opioid Dependence, Opioid Withdrawal
- Trial name
- NCT03813095
- Testing
- APH-1501
- Volunteers
- 32 people
- Sponsor
- Aphios
Cocaine Dependence
A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts
This study represents a randomized, double blind placebo-controlled trial. Thirty cocaine dependant patients will be included in this study during their hospitalization for withdrawal.
- Trial name
- RAPID (NCT02134002)
- Testing
- Disulfiram
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cocaine Addiction, Cocaine Abuse
Pramipexole as a Treatment for Cocaine Dependence
The purposes of this study are as follows: 1. To assess the cardiovascular and subjective effects of cocaine during treatment with pramipexole and placebo. 2.
- Conditions
- Cocaine Addiction, Cocaine Abuse, Cocaine Dependence, Substance Abuse
- Trial name
- NCT01651377
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Serotonin/Dopamine Antagonism of Cocaine Effect: 2 - 2
The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.
- Trial name
- NCT00000310
- Testing
- Risperidone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence, Cocaine Dependence
Human Behavioral Pharmacology Laboratory (HBPL) Study of Varenicline's Impact on Cocaine and Alcohol Craving
This is a Phase II within-subjects double-blind placebo-controlled human laboratory study. The purpose of the study is to determine the efficacy of varenicline (Chantix) for reducing cue-induced cocaine and alcohol craving.
- Trial name
- NCT01151813
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
A Placebo-Controlled Double-Blind Combined Treatment of Modafinil and CBT for Cocaine Dependence
The purpose of this study is to test whether a cognitive behavioral therapy (CBT) and a medication called modafinil, which is approved to treat sleep disorders, will help individuals who are abusing cocaine.
- Trial name
- NCT00344565
- Testing
- Modafinil, Cognitive Behavioral Therapy--Relapse Prevention
- Volunteers
- 15 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Cocaine-Related Disorders
Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the treatment of cocaine dependence using reserpine, gabapentin, or lamotrigine vs. an unmatched placebo control.
- Trial name
- NCT00015106
- Testing
- Lamotrigine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effectiveness and Costs of Enhanced Cocaine Treatments
The study will evaluate the effectiveness, economic benefits, and costs of voucher reinforcement for cocaine and alcohol abstinence, additional counseling services, and their combination in a sample of cocaine dependent patients…
- Trial name
- NCT00167258
- Testing
- Voucher Reinforcement, Extra Counseling Services, Voucher Reinforcement + Extra Counseling Services
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Metabolic Effects of Cocaine
The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence
- Trial name
- NCT00451230
- Testing
- cocaine, hydrocortisone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Drug Abuse (NIDA)