Clinical trials: Cocaine-related Disorders
Opioid Dependence, Opioid Related Disorders
A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abuse
This is a randomized, 4-sequence, 2-period, double-blind, placebo controlled study in male and female subjects with an American Psychiatric Association Diagnostic and Statistical Manual DSM-IV-TR diagnosis of cocaine abuse.
- Conditions
- Opioid Dependence, Opioid Related Disorders, Cocaine Dependence
- Trial name
- RBP-8000 (NCT01846481)
- Testing
- RBP-8000 100 mg, Cocaine, RBP-8000 200 mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Cocaine-Related Disorders
Developing Adaptive Interventions for Cocaine Cessation and Relapse Prevention
First, the investigators will determine whether Acceptance and Commitment Therapy in combination with Contingency Management increases initial treatment response rates.
- Trial name
- NCT02896712
- Testing
- Acceptance and Commitment Therapy (ACT), Drug Counseling (DC), Contingency Management (CM)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-related Disorders
Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT…
- Trial name
- NCT00877435
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Risperidone for Treatment of Cocaine Dependence in Outpatients - 12
The purpose of this study is to evaluate pharmacological efficacy and clinical safety of risperidone in the treatment of cocaine and amphetamine dependence.
- Trial name
- NCT00000347
- Testing
- Risperidone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Dextroamphetamine as an Adjunct in Cocaine Treatment - 1
The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in cocaine treatment; an evaluation of the ""replacement"" strategy.
- Trial name
- NCT00000304
- Testing
- Dextroamphetamine, D-Amphetamine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Infusion Laboratory: Protocol 2 (Lisuride) - 3
The purpose of this study is to evaluate clinical safety issues pertaining to lisuride, to cocaine, and to its interaction in a chronic, crack dependent population, and to determine how pretreatment with lisuride modifies the…
- Trial name
- NCT00000338
- Testing
- Lisuride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Stimulant Use Disorder
Smartphone Services for Stimulant Use Disorder
This study is testing two approaches to treating Stimulant Use Disorder, or problems with cocaine, crack, methamphetamine, etc. Stimulant Use Disorder is a national epidemic in the U.S.
- Trial name
- NCT07092059
- Testing
- Smartphone digital therapeutic system
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- DynamiCare Health
Cocaine Use Disorder, Cocaine Dependence
TDCS for Cocaine Addiction Craving
Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation in which low level electrical currents are applied to the scalp in order to alter brain function.
- Trial name
- NCT03833583
- Testing
- Soterix Medical mini-CT tDCS stimulator
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 2
The purpose of this study is to evaluate the effects of fluoxetine maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.
- Trial name
- NCT00000213
- Testing
- Fluoxetine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts.
- Trial name
- NCT03471182
- Testing
- Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid-use Disorder, Cocaine Use Disorder
Navigation Services to Avoid Rehospitalization (NavSTAR)
This study will examine the clinical effectiveness and health economic profile of services to link hospital patients with substance use disorders to addiction treatment, promote their medical stabilization, and reduce hospital…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Alcohol Use Disorder
- Trial name
- NavSTAR (NCT02599818)
- Testing
- NavSTAR
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Friends Research Institute, Inc.
Cocaine Use Disorder
Efficacy of Repetitive Transcranial Magnetic Stimulation in Reducing Cocaine Intake in Addicted Patients
The study evaluates the efficacy of 3 weeks of repetitive transcranial magnetic stimulation (rTMS), 5 sessions/weekly, in reducing cocaine consumption immediately after and within the 8 weeks following the treatment in addicted…
- Trial name
- MagneTox (NCT03607591)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Cocaine-Related Disorders
Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218062
- Testing
- D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Abuse
Computer-Based Training in Cognitive Behavior Therapy
The computer-based training program (CBT for CBT) focuses on teaching basic coping skills, presenting examples of effective use of coping skills in a number of realistic situations in video form, and providing opportunities for…
- Trial name
- CBT4CBT (NCT00350610)
- Testing
- Treatment as usual (TAU), CBT for CBT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Addiction, Cocaine
Attention Training for Opioid-maintained Cocaine Users
The purpose of this study is to determine the feasibility and preliminary efficacy of attention training using a portable electronic device for opioid-dependent cocaine-users stabilized on methadone.
- Conditions
- Addiction, Cocaine, Methadone, Opiates
- Trial name
- NCT01870882
- Testing
- Attentional retraining, Control condition
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Adult Attention Deficit Hyperactivity Disorder, Cocaine Dependence
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
The proposed protocol is a 3 group double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) in the treatment of comorbid ADHD and cocaine dependence.
- Trial name
- CAMP (NCT00553319)
- Testing
- Adderall-XR
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders, Substance Withdrawal Syndrome
Acute Withdrawal From Smoked Cocaine - 9
The purpose of this study is to develop an experimental paradigm to examine acute withdrawal symptoms from cocaine.
- Conditions
- Cocaine-Related Disorders, Substance Withdrawal Syndrome, Substance-Related Disorders
- Trial name
- NCT00000292
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Nicotine Dependence
Progesterone and Atomoxetine for Cocaine Cessation
The purpose of this study is to examine the role of progesterone (a hormone found in both men and women) on stopping cocaine use.
- Trial name
- NCT01741376
- Testing
- Progesterone
- Where
- United States
- Sponsor
- University of Minnesota
Cocaine Use Disorders, HIV
Project IMPACT: Improving Memory Performance by Applying Cognitive Training
The purpose of this study is to examine the effects of a cognitive training program in persons with Human Immunodeficiency Virus (HIV) infection who have used cocaine.
- Trial name
- NCT02909101
- Testing
- Active Cognitive Training (ACT), Control Training (CON)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University