Clinical trials: Cocaine-related Disorders
Cocaine Use Disorder, Cocaine Dependence
TDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study
Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation in which low level electrical currents are applied to the scalp in order to alter brain function.
- Trial name
- NCT04994821
- Testing
- transcranial direct current stimulator (tDCS), Cognitive Reappraisal
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Soterix Medical
Cocaine Dependence
Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
The proposed protocol is a multi-site double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (MAS-ER) and topiramate in the treatment of cocaine dependence.
- Trial name
- TACT2 (NCT01811940)
- Testing
- Adderall-ER, Topiramate
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders, Substance-Related Disorders
Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5
The purpose of this study is the use of Methylphenidate in the treatment of cocaine dependence and Attention Deficit Hyperactivity Disorder (ADHD) comorbidity.
- Trial name
- NCT00015223
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Behavioral Incentives to Increase Exercise in Cocaine Dependent Women
While physical activity has been associated with decreased craving and increased abstinence rates in smokers, few published studies have examined the effects of exercise on recovery from other drugs such as cocaine.
- Trial name
- NCT01283191
- Testing
- Behavioral Incentives, Education Control
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Cocaine Addiction
Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving
We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue…
- Trial name
- LIDO (NCT01929343)
- Testing
- lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Bryon Adinoff
Cocaine Addiction
Efficacy of N-acetylcysteine on the Craving Symptoms of Abstinent Hospitalized Patients With Cocaine Addiction
Cocaine abuse is associated with serious physical, psychiatric and social problems. Addiction results in the compulsive use of a substance with loss of control and persistence despite the negative consequences.The act of…
- Trial name
- NCT03423667
- Testing
- N-acetylcysteine, Lactose powder
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- Salvatore Campanella
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 2
The purpose of this study is to evaluate the effects of fluoxetine maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.
- Trial name
- NCT00000213
- Testing
- Fluoxetine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
An fMRI Study of SYN115 in Cocaine Dependent Subjects
The dopamine system is critical in modulation of reward and has been implicated in the initiation and maintenance of addiction (Volkow et al 2004).
- Trial name
- NCT00783276
- Testing
- SYN115
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders
Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.
- Trial name
- NCT00100113
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine
Cocaine abuse continues to represent a significant public-health concern. Cocaine likely creates its addictive effects by increasing levels of dopamine, a chemical found in the brain.
- Trial name
- NCT00218166
- Testing
- GABA Agonists
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Impulsivity
Impulsivity and Stimulant Administration
Examine the interaction between stimulants, such as cocaine and methylphenidate, and impulsivity.
- Trial name
- NCT01978431
- Testing
- cocaine hydrochloride, methylphenidate
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine-Related Disorders
Dopamine Reuptake Inhibitors of Cocaine Abuse - 1
The purpose of this study is to evaluate dopamine reuptake inhibitors for cocaine abuse.
- Trial name
- NCT00000276
- Testing
- Bupropion
- Where
- United States
- Sponsor
- Yale University
Cocaine Abuse
Prize Contingency Management for Cocaine-Dependent Methadone Patients
The investigators will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a contingency management condition that arranges a 100% probability of winning a prize with each draw and…
- Trial name
- NCT01401270
- Testing
- prize contingency management
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- UConn Health
Cocaine-Related Disorders
Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1
Although a great amount of research has been conducted to resolve cocaine dependence, an effective treatment has yet to be discovered. Topiramate is a drug that was found to be useful in treating alcohol dependence.
- Trial name
- NCT00249691
- Testing
- Topiramate + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bankole Johnson
Cocaine-Related Disorders, Substance-Related Disorders
Quetiapine for Cocaine Use and Cravings
The purpose of this study was to collect pilot data on whether quetiapine may be effective in the reduction of cocaine use and cravings in cocaine dependent individuals.
- Trial name
- NCT00232336
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Cocaine Dependence, Cocaine Addiction
Exercise as a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to test the effects of exercise on cocaine use, fitness, and cravings for cocaine and nicotine. This study is part of an effort to develop treatments for cocaine abuse.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01601743
- Testing
- Sitting, Running, Walking
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Substance Related Disorders, Drug Addiction
Contingency Management for Cocaine Dependence: Cash Versus Vouchers
Contingency management (CM) is a demonstrably efficacious intervention for substance abuse and dependence. Although CM protocols have employed a variety of reinforcers, they have almost exclusively relied upon non-cash privileges…
- Conditions
- Substance Related Disorders, Drug Addiction, Substance Abuse
- Trial name
- NCT01366716
- Testing
- Cash CM, Voucher CM
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Treatment Research Institute
Cocaine Dependence, Opiate Dependence
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
The main goal of this study is to evaluate the safety and tolerability of 40 or 80 mg atomoxetine as a treatment for cocaine dependence.
- Trial name
- NCT01802515
- Testing
- Atomoxetine, low dose, Atomoxetine, high dose
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University