Clinical trials: Cocaine-related Disorders
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Substance Abuse
Evaluation of Atomoxetine for Cocaine Dependence: A Pilot Trial
This placebo-controlled, double-blind, randomized pilot clinical trial will evaluate atomoxetine (Strattera®) for the treatment of cocaine dependence.
- Trial name
- NCT00617201
- Testing
- atomoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Cocaine Dependence
Cognitive Remediation for Cocaine Dependence
The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.
- Trial name
- NCT01393457
- Testing
- levodopa/carbidopa, Ropinirole 2 mg/d, Ropinirole 4 mg/d
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center, Houston
Substance-Related Disorders
Methylphenidate for Cocaine Dependence
This phase II pilot study aims at evaluating the benefits and the risks of methylphenidate (Concerta®) for the treatment of cocaine/crack dependence in terms of cocaine/crack use reduction and adverse events.
- Trial name
- ANRS STIMAGO (NCT03090269)
- Testing
- Methylphenidate Pill
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Mania, Hypomania
Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence
The purpose of this research is to determine if a citicoline supplement is associated with a reduction in cocaine use and craving in patients with bipolar disorder (a mental disorder marked by alternating periods of mania and…
- Conditions
- Mania, Hypomania, Cocaine Abuse, Cocaine Dependence
- Trial name
- NCT00223236
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Texas Southwestern Medical Center
Cognition Disorders, Cocaine Dependence
Repetitive Transcranial Magnetic Stimulation in Symptoms of Attention Deficit Hyperactivity Disorder and Cognitive Function In Cocaine Addicts
Even in the absence of a preliminary diagnosis of Attention Deficit Hyperactivity Disorder, symptoms of attention deficit, hyperactivity and cognitive impairment are common in cocaine addicts.
- Conditions
- Cognition Disorders, Cocaine Dependence, ADHD
- Trial name
- rTMSinADHD (NCT01593982)
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine Dependence
Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence
Trial to determine the safety, efficacy and tolerability of acamprosate for the treatment of cocaine dependence.
- Trial name
- CAMPRAL (NCT00385268)
- Testing
- acamprosate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
High Dose Nimodipine Treatment Adjunct - 1
The purpose of this study is to determine if nimodipine is more effective than placebo in reducing stimulated craving for cocaine in cocaine dependent individuals denied access to cocaine in inpatient unit.
- Trial name
- NCT00000332
- Testing
- Nimodipine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction, Alcohol Addiction
Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.
This study evaluates the use of N-acetylcysteine in the treatment of alcohol and cocaine use disorders. Alcohol users will be split in two groups, one will receive the active N-acetylcysteine and the other placebo.
- Trial name
- NCT03018236
- Testing
- Alcohol N-acetylcysteine, Cocaine N-acetylcysteine
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cocaine-Related Disorders
Cocaine-Methylphendidate Interaction Study - 4
The purpose of this study is to attempt to identify possible dangerous interactions between cocaine and methylphenidate (MPD). Additional objectives are to determine: a) if MPD reduces the craving and high for cocaine; b) if…
- Trial name
- NCT00015067
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse…
- Trial name
- NCT01535937
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Developing Adaptive Interventions for Cocaine Cessation and Relapse Prevention
First, the investigators will determine whether Acceptance and Commitment Therapy in combination with Contingency Management increases initial treatment response rates.
- Trial name
- NCT02896712
- Testing
- Acceptance and Commitment Therapy (ACT), Drug Counseling (DC), Contingency Management (CM)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Enhanced and Attendance-based Prize CM in Community Settings
The purpose of this study is to address the conditions under which prize contingency management (CM) for abstinence and attendance may improve outcomes of cocaine-dependent patients.
- Trial name
- NCT00606853
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 443 people
- Sponsor
- UConn Health
Cocaine-Related Disorders
Development of Human Laboratory Study Model of Cocaine Relapse Prevention. - 1
The purpose of this study is to assess the development of human laboratory study model of cocaine relapse prevention.
- Trial name
- NCT00040066
- Testing
- Cocaine (IV)
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Stimulant Use Disorder
Smartphone Services for Stimulant Use Disorder
This study is testing two approaches to treating Stimulant Use Disorder, or problems with cocaine, crack, methamphetamine, etc. Stimulant Use Disorder is a national epidemic in the U.S.
- Trial name
- NCT07092059
- Testing
- Smartphone digital therapeutic system
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- DynamiCare Health
Cocaine Dependence
Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function.
- Trial name
- NCT06189690
- Testing
- rTMS
- Where
- Mexico
- Volunteers
- 102 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Opioid Dependence, Cocaine Abuse
Combined Behavioral and Pharmacologic Treatment of Polydrug Abuse
The primary goal of this study is to determine how contingency management can best be combined with standard or high doses of methadone to increase simultaneous abstinence from heroin and cocaine.
- Trial name
- NCT00292123
- Testing
- Methadone, Contingency Management
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders
To use pregnenolone (PREG; 300; 500mg) daily versus placebo (PLA) as a probe to assess the role of neuroactive steroids in individuals with cocaine use disorder (CUD).
- Trial name
- NCT03953612
- Testing
- Pregnenolone (PREG)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Predictive Values of Serotonergic Alterations for Outcome - 2
The purpose of this study is to evaluate the predictive value of serotonergic alterations for outcome.
- Trial name
- NCT00000313
- Testing
- Fenfluramine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder, Cocaine Use Disorder
Navigation Services to Avoid Rehospitalization (NavSTAR)
This study will examine the clinical effectiveness and health economic profile of services to link hospital patients with substance use disorders to addiction treatment, promote their medical stabilization, and reduce hospital…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Alcohol Use Disorder
- Trial name
- NavSTAR (NCT02599818)
- Testing
- NavSTAR
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Friends Research Institute, Inc.