Clinical trials: Cocaine-related Disorders
Substance Abuse Problem, Pregnancy
Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology
The purpose of this research is to study the effects of nasal oxytocin administration on maternal behaviors that may be influenced by cocaine use during pregnancy.
- Trial name
- NOX (NCT02872467)
- Testing
- Syntocinon treatment
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cocaine-Related Disorders
Modafinil for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of modafinil in reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT00100100
- Testing
- Modafinil
- Where
- 6 sites in United States
- Volunteers
- 210 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Assessment of Potential Interactions Between Cocaine and Tolcapone - 1
The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.
- Trial name
- NCT00033059
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Heroin Abuse
Effect of Clonidine on Responses to Imagery Scripts
Background: Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats.
- Trial name
- NCT00318760
- Testing
- Clonidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effect of Oxytocin on Stress Response in Cocaine-dependent Individuals
Stress is associated with drug craving and relapse in substance-dependent individuals. Hormones released from the brain may mediate the behavioral response to stress.
- Trial name
- NCT01963091
- Testing
- oxytocin, saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Substance-Related Disorders
Flupenthixol and Haloperidol for Treating Cocaine Abuse Schizophrenics - 9
The purpose of this study is to evaluate the safety and efficacy of flupenthixol and haloperidol for cocaine dependence in individuals with schizophrenia/schizoaffective illness.
- Trial name
- NCT00000274
- Testing
- Flupenthixol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse…
- Trial name
- PET-CRA (NCT00376558)
- Testing
- Community Reinforcement Approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Chantix for Treating Cocaine Dependence
The purpose of this study is to determine whether varenicline (Chantix), is effective for the treatment of cocaine dependence.
- Trial name
- NCT00567008
- Testing
- varenicline
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Effects of Propranolol on Responses to Drug-Related Imagery Scripts
Background: Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of…
- Trial name
- NCT00688805
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse or Dependence, Cocaine Related Disorders
Effects of N-acetylcysteine on Brain Chemistry and Behavior in Cocaine Abusers (NAC)
N-acetylcysteine (NAC) is a medication that the Food and Drug Administration (FDA) has approved for several medical uses, such as dissolving mucus in patients with breathing problems, treating overdose from acetaminophen…
- Trial name
- NAC (NCT01392092)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine Dependence
Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336 in Healthy, Male Subjects
This is the first study to be conducted in humans for RTI-336, a new chemical entity, with evaluations focusing on the safety, tolerability, and pharmacokinetics of RTI-336 following administration of single, oral doses.
- Trial name
- NCT00808119
- Testing
- RTI-336 (CTDP 31862)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- RTI International
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy and Intensive Treatment of Drug Abuse - 1
The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.
- Trial name
- NCT00000217
- Testing
- Carbamazepine
- Where
- United States
- Sponsor
- University of Kansas
Cocaine-Related Disorders, Opiate Dependence
Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1
Many opioid-dependent individuals are also dependent on cocaine. Methadone is a widely used and effective method for treating opioid dependence. However, it is not effective in treating other drugs of abuse.
- Trial name
- NCT00129298
- Testing
- Tiagabine
- Volunteers
- 80 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Opioid-Related Disorders
Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid Use Disorder and Cocaine Use Disorder
The purpose of Project 2 is to execute phase I functional magnetic resonance imaging (fMRI) studies to assess the effects of lorcaserin on brain target engagement (measured by fMRI brain activation and neural connectivity) in…
- Trial name
- NCT03143543
- Testing
- Group A Lorcaserin (10mg), Group A2 Lorcaserin (20 mg)
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000315
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Clavulanic Acid for the Treatment of Cocaine Use Disorder
A dose escalation study to assess the efficacy and safety of Clavulanic Acid (CLAV) vs. placebo (PBO) for the treatment of cocaine use disorder (CUD)
- Trial name
- NCT05562349
- Testing
- Clavulanic Acid Only Product
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Temple University
Cocaine-Related Disorder, Opiate Dependence
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
This 18-week, randomized, double blind clinical trial provided treatment for 160 cocaine-dependent opioid addicts, aged 18-65 years.
- Trial name
- NCT00580827
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Amantadine, a medication that improves muscle control, and propranolol, a medication that lowers blood pressure, may be…
- Trial name
- NCT00158132
- Testing
- Propranolol, Amantadine
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders, Substance-Related Disorders
Nefazodone in the Treatment of Cocaine Dependence and Depression - 4
The purpose of this study is the use of Nefazodone in the treatment of cocaine dependence and depression comorbidity.
- Trial name
- NCT00015210
- Testing
- Nefazodone, Psychosocial Treatment
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Boston Medical Center
Bipolar Disorder, Cocaine Dependence
A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence
The purpose of this study is to determine whether quetiapine or risperidone are effective in treating mood symptoms, drug cravings and use in bipolar disorder with concurrent cocaine or methamphetamine dependence.
- Conditions
- Bipolar Disorder, Cocaine Dependence, Methamphetamine Dependence
- Trial name
- NCT00227123
- Testing
- quetiapine, risperidone
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Texas Southwestern Medical Center