Clinical trials: Cocaine-related Disorders
Schizophrenia, Cocaine Dependence
A Double-Blind, Controlled Study of Aripiprazole in Co-Morbid Schizophrenia and Cocaine Dependence
The purpose of this study is to gather systematic clinical data on whether aripiprazole, a partial dopamine agonist, beneficially affects schizophrenia plus cocaine dependence subjects.
- Trial name
- NCT00737256
- Testing
- Aripiprazole, Perphenazine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Paul Saenger
Methamphetamine or Cocaine Dependence
Doxazosin for Psychostimulant Dependence
Psychostimulant dependence is a major public health problem and no medications have been shown to be very effective in treating this disorder.
- Trial name
- NCT01371851
- Testing
- Doxazosin extended release
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arkansas
Cocaine Dependence
Pharmacogenetics of Doxazosin for Cocaine Dependence
Doxazosin, an alpha 1-adrenergic receptor antagonist, may play an important role in cocaine addiction in humans. This study will evaluate to what extent the prospective screening for catecholamine related polymorphisms for alpha…
- Trial name
- NCT01145183
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence, Healthy
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS
This study is designed to look at the relationship between brain glucose utilization, neurotransmission (e.g., glutamate, also known as the main excitatory amino-acid neurotransmitter in the brain), and synaptic density.
- Trial name
- NCT02124941
- Testing
- N-acetyl cysteine, [18F]FDG PET scan, 1H MRS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Use, Substance Abuse
Harm Reduction Services
The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve harm reduction service utilization among Black and Latinx people who…
- Conditions
- Drug Use, Substance Abuse, Mental Illness
- Trial name
- HRS (NCT05776316)
- Testing
- Integrated Harm Reduction Intervention (IHRI)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Heroin Dependence, Opioid-Related Disorders
Treatment Study: Reducing Cocaine/Heroin Abuse With SR-Amphetamine and Buprenorphine (ARC)
This research study takes place at Wayne State University and will take about 11 weeks to complete. This is a treatment research study for individuals who currently have cocaine abuse or dependence, and who may also have heroin…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- ARC (NCT00698737)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wayne State University
Cocaine Abuse, Cocaine-Related Disorders
Progesterone for the Treatment of Cocaine Dependence - 1
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high.
- Trial name
- NCT00218257
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota
Cocaine-Related Disorders, Substance-Related Disorders
Pathophysiological Subtyping of Abnormalities in Cocaine Dependence - 9
The purpose of this study is to define pathophysiological subtypes of abnormalities in subjects with cocaine dependence.
- Trial name
- NCT00015275
- Testing
- Cocaine-Related Disorders
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
The investigators' recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other…
- Trial name
- NCT01822587
- Testing
- Propranolol, 40 mg, Propranolol, 80 mg
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence, Depression
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
This research study is being done to look at the safety of the medication Mirtazapine (Remeron) in people who have cocaine dependence and depression. Hypotheses I.
- Trial name
- NCT00322309
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 2
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000211
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence
Cocaine dependence is a major public health problem and the development of a treatment for this disorder is a priority. To date, treatment interventions based on positive incentive principles have shown the strongest effects for…
- Trial name
- NCT00713583
- Testing
- levodopa, Cognitive Behavioral Therapy, Contingency Management
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
A Placebo-Controlled Double-Blind Combined Treatment of Modafinil and CBT for Cocaine Dependence
The purpose of this study is to test whether a cognitive behavioral therapy (CBT) and a medication called modafinil, which is approved to treat sleep disorders, will help individuals who are abusing cocaine.
- Trial name
- NCT00344565
- Testing
- Modafinil, Cognitive Behavioral Therapy--Relapse Prevention
- Volunteers
- 15 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Cocaine-Related Disorders, Substance-Related Disorders
Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11
The purpose of this study is to evaluate PET methodology to study in vivo synaptic dopamine release.
- Trial name
- NCT00015301
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Modeling Impaired Judgement in Cocaine Abusers - 6
The purpose of this study is for the modeling of impaired judgement in cocaine abusers.
- Trial name
- NCT00015236
- Testing
- Amantadine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Modafinil for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and safety of modafinil in reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT00100100
- Testing
- Modafinil
- Where
- 6 sites in United States
- Volunteers
- 210 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effectiveness of Extended Treatment for Drug Dependence (ETDD) in the City Study
This protocol (a supplement to 805466) is to test whether our telephone continuing care model can be implemented successfully by "real world" publicly funded programs.
- Trial name
- NCT01153464
- Testing
- Recovery Support Counseling
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania