Clinical trials: Cocaine-related Disorders
Cocaine Dependence
Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence
The proposed protocol is an open-label pilot study of the treatment of cocaine dependence using lisdexamfetamine (LDX), a prodrug of d-amphetamine.
- Trial name
- Vyvance (NCT01486810)
- Testing
- Lisdexamfetamine, medication management
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Substance Abuse
Screening Protocol for Research Participants
The Screening Protocol is a system devised to evaluate potential research participants for National Institute on Drug Abuse/Maryland Psychiatric Research Center (NIDA/MPRC) studies.
- Conditions
- Schizophrenia, Substance Abuse, Cocaine Abuse, Tobacco Use Disorder
- Trial name
- ScreenProt (NCT01010620)
- Testing
- Various Screening psychiatric and medical assessments
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cocaine Use Disorder, Cocaine Dependence
TDCS for Cocaine Addiction Craving
Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation in which low level electrical currents are applied to the scalp in order to alter brain function.
- Trial name
- NCT03833583
- Testing
- Soterix Medical mini-CT tDCS stimulator
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Cocaine-Related Disorders
Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine use in depressed and non-depressed females with cocaine abuse/dependence.
- Trial name
- NCT00000293
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV, AIDS
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
This study will evaluate the efficacy of an integrated "Retention Clinic" in achieving virologic suppression among HIV-infected cocaine (including crack) users by using a two-group randomized, prospective trial.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- NCT01614106
- Testing
- Retention Clinic
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Behavior, Addictive, Cocaine Abuse
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2
The purpose of this study is to determine whether long-term exposure to the Therapeutic Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed…
- Conditions
- Behavior, Addictive, Cocaine Abuse, Cocaine Dependence, Heroin Dependence
- Trial name
- NCT00249457
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Complementary Combination Therapy for Cocaine Dependence
The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers.
- Trial name
- NCT02538744
- Testing
- Doxazosin, Modafinil, cocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorders
D-Cycloserine and Cue Exposure in Cocaine-Dependent Individuals
In summary, this pilot study will explore the use of an innovative pharmacologic approach to the treatment of substance dependence through the facilitation of extinction of response to cocaine-conditioned cues in…
- Trial name
- NCT00780442
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Medical University of South Carolina
Cocaine Use Disorder
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
The purpose of this study is to see how well pioglitazone, when used with cognitive behavioral therapy, works at helping people who have recently stopped using cocaine to continue to not use cocaine.
- Trial name
- NCT04843046
- Testing
- Cognitive Behavioral Therapy (CBT), Pioglitazone
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence
Cocaine dependence is a major public health problem and the development of a treatment for this disorder is a priority. To date, treatment interventions based on positive incentive principles have shown the strongest effects for…
- Trial name
- NCT00713583
- Testing
- levodopa, Cognitive Behavioral Therapy, Contingency Management
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- The University of Texas Health Science Center, Houston
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3
The purpose of this study is to determine the effects of nefazedone on cocaine self-administration in depressed and non-depressed female cocaine users.
- Trial name
- NCT00000286
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Serotonin, Impulsivity, and Cocaine Dependence Treatment
The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.
- Trial name
- NCT00297505
- Testing
- citalopram
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Opioid Dependency
Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients
Concurrent dependence on cocaine occurs in up to 50% of the over one million opiate dependent patients in spite of methadone maintenance treatment being highly effective for opiate dependence and having excellent treatment…
- Trial name
- Keppra-DB (NCT00577005)
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Infusion Laboratory: Protocol 1 - Selegeline - 2
The purpose of this study is to determine the effects of selegiline on the subjective and physiological effects of cocaine challenge in chronic crack abusers, and to evaluate clinical safety issues pertaining to selegeline, to…
- Trial name
- NCT00000337
- Testing
- Selegiline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction, Cocaine Abuse
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine
The purpose of the study is to asses the potential interactions between intravenous cocaine and doxazosin in cocaine dependent volunteers who are not seeking treatment.
- Conditions
- Cocaine Addiction, Cocaine Abuse, Cocaine Dependence, Substance Abuse
- Trial name
- NCT01062945
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Pemoline for Cocaine Abuse - 7
The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse.
- Trial name
- NCT00000282
- Testing
- Pemoline
- Where
- United States
- Sponsor
- Yale University
Cocaine-Related Disorders
Lorcaserin in the Treatment of Cocaine Use Disorder
The objective of this study is to evaluate the efficacy and safety of lorcaserin in the treatment of cocaine use disorder.
- Trial name
- NCT03007394
- Testing
- Lorcaserin
- Where
- 12 sites in United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)