Clinical trials: Cocaine-related Disorders
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Cocaine, Substance Abuse
The Maternal Lifestyle Study (MLS)
This is a longitudinal, multi-site observational study of the long-term effects of a mother's use of cocaine and/or opiates during pregnancy on her infant.
- Conditions
- Cocaine, Substance Abuse, Infant, Newborn, Pregnancy
- Trial name
- MLS (NCT00059540)
- Where
- 5 sites in United States
- Volunteers
- 11,811 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Cocaine Dependence
Glutamatergic Modulation of Cocaine-related Deficits
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
- Trial name
- NCT01790490
- Testing
- Ketamine 0.41 mg/kg, Ketamine 0.71 mg/kg, Lorazepam 2 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1
The purpose of this study is to assess potential interactions between intravenous (i.v.) cocaine and atomoxetine (Strattera) administered orally in four escalating doses.
- Trial name
- NCT00265265
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction
Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder
Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction.
- Trial name
- NCT03025321
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- Erasmus Medical Center
Alcoholism, Cocaine Addiction
The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues
High relapse rates among substance dependent individuals are likely due to a combination of factors that involve limbic circuits in the brain involved in craving, including vulnerability to salient cues.
- Conditions
- Alcoholism, Cocaine Addiction, Drug Addiction
- Trial name
- addictionTBS (NCT02939352)
- Testing
- Real continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Drug Abuse, Cocaine Dependence
Brain Glutamate Receptors and Cocaine Dependence
Objective: Cocaine addiction continues to be an important public health problem with over 1.7 million users in the US alone. Cocaine addiction is characterized by compulsive drug use despite adverse consequences and high rates of…
- Trial name
- NCT00951314
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-related Disorders
Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT…
- Trial name
- NCT00877435
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Cocaine Addiction
Integrative Meditation (IM) for Cocaine Addiction
Cocaine addiction continues to be a major problem in the U.S. with no FDA-approved pharmaceutical therapy. Finding effective treatment for cocaine addiction has long been a challenge to scientists and clinicians.
- Trial name
- NCT01211418
- Testing
- Integrative Meditation, Supportive Counseling
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Maryland, Baltimore
Cocaine Use Disorder
Efficacy of Repetitive Transcranial Magnetic Stimulation in Reducing Cocaine Intake in Addicted Patients
The study evaluates the efficacy of 3 weeks of repetitive transcranial magnetic stimulation (rTMS), 5 sessions/weekly, in reducing cocaine consumption immediately after and within the 8 weeks following the treatment in addicted…
- Trial name
- MagneTox (NCT03607591)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Cocaine-Related Disorders
Carbamazepine Treatment for Cocaine Dependence - 5
The purpose of this study is to assess carbamazepine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000191
- Testing
- Carbamazepine
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Measuring Distress Tolerance With Functional MRI
Background: People who are in treatment for substance abuse often feel distress during the withdrawal period and afterward. Some individuals feel distress more acutely than others, and this distress has been linked to poor…
- Trial name
- NCT01038232
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
The investigators plan to explore the effects of acute pre-treatment with the glucagon like peptide-1 (GLP-1) agonist, exenatide versus placebo, on the subjective (e.g., euphoric) and behavioral effects (e.g.…
- Trial name
- NCT02302976
- Testing
- cocaine hydrochloride, exenatide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Cocaine Withdrawal, Cocaine Smoking
Use of Intranasal Oxytocin During Detoxification of Crack Cocaine
This study investigated whether adding oxytocin nasal spray to usual inpatient treatment could reduce withdrawal, anxiety, and depressive symptoms in women hospitalized for cocaine detoxification.
- Conditions
- Cocaine Withdrawal, Cocaine Smoking, Cocaine-Related Disorders
- Trial name
- NCT04306354
- Testing
- Oxytocin nasal spray, Conventional Inpatient Treatment
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Substance Abuse, Intravenous
The Long-Term Treatment of Drug Addiction and Unemployment
The purpose of this clinical trial is to evaluate the effectiveness and economic benefits of a Wage Supplement Model of arranging long-term exposure to employment-based abstinence reinforcement.
- Trial name
- NCT02487745
- Testing
- Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Johns Hopkins University
Substance Use Disorder, Cocaine Dependence
Cannabidiol and Cocaine Craving/Dependence
In this study, the investigators seek to evaluate the effects of cannabidiol (CBD) on cocaine craving and relapse. Cocaine addiction is characterized by compulsive substance use and repetitive urges to consume the drug even after…
- Conditions
- Substance Use Disorder, Cocaine Dependence, Withdrawal From Addictive Substance; Detoxification
- Trial name
- CBD (NCT02559167)
- Testing
- Cannabidiol
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cocaine Dependence
Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence
In a randomized, double-blind controlled trial the investigators will evaluate the efficacy of rTMS in reducing impulsivity for cocaine addicts through - Quantitative and qualitative analysis - such behavior and possible…
- Trial name
- TMSCOCAINE (NCT01397266)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy for Schizophrenic Drug Users - 6
The purpose of this study is to evaluate maintenance neuroleptics for Schizophrenic patients who are cocaine abusers.
- Conditions
- Cocaine-Related Disorders, Substance-Related Disorders, Shcizophrenia
- Trial name
- NCT00000281
- Testing
- Amantadine
- Where
- United States
- Sponsor
- Yale University
Cocaine Dependence
Ovarian Hormones and Stress Induced Drug Craving
The study is investigating the impact of progesterone and estrogen on brain areas that are involved with stress response and drug craving.
- Trial name
- NCT02098434
- Testing
- Montreal Imaging Stress Task
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Abuse, Cocaine-Related Disorders
The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3
Gamma-aminobutyric acid (GABA) is a type of neurotransmitter, which is a chemical that transmits information within and from the brain to all parts of the body.
- Trial name
- NCT00142883
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University