Clinical trials: Cocaine-related Disorders
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine Dependence
Modafinil, Sleep Architecture and Cocaine Relapse
The medication modafinil has been shown to reduce cocaine use in some cocaine users. The investigators have shown that modafinil taken in the morning improves sleep in chronic cocaine users.
- Trial name
- NCT01137396
- Testing
- Modafinil, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Yale University
Cocaine Dependence, Alcohol Dependence
HBPL Study of the Impact of the NK1 Antagonist Aprepitant
The proposed research will focus on investigating the determinants and consequences of CAD via measurement of physiological, behavioral and subjective effects of physiologic and psychologic stress cues in CAD volunteers in the…
- Trial name
- NCT01176591
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Acoustic Startle Reduction In Cocaine Dependence
Chronic cocaine administration leads to changes in brain function that persist long after the acute withdrawal phase. The acoustic startle response (ASR) is a well characterized reflexive response to a sudden acoustic stimulus.
- Trial name
- NCT00430690
- Testing
- acoustic startle testing
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Emory University
Addiction, Cocaine
Attention Training for Opioid-maintained Cocaine Users
The purpose of this study is to determine the feasibility and preliminary efficacy of attention training using a portable electronic device for opioid-dependent cocaine-users stabilized on methadone.
- Conditions
- Addiction, Cocaine, Methadone, Opiates
- Trial name
- NCT01870882
- Testing
- Attentional retraining, Control condition
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Cocaine Abuse and Dependence
Use of Donepezil for Treatment of Cocaine Dependence
The purpose of this study is to determine the safety of intravenous cocaine in subjects receiving oral donepezil.
- Trial name
- NCT00467389
- Testing
- Donepezil, 5 mg daily
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Cocaine Dependence, Healthy
Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 1H-MRS
This study is designed to look at the relationship between brain glucose utilization, neurotransmission (e.g., glutamate, also known as the main excitatory amino-acid neurotransmitter in the brain), and synaptic density.
- Trial name
- NCT02124941
- Testing
- N-acetyl cysteine, [18F]FDG PET scan, 1H MRS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Use Disorder, Cocaine Dependence
Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder.
- Trial name
- Co-Boost (NCT06125054)
- Testing
- Ketamine, real-time fMRI neurofeedback training
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Marcus Herdener
Stimulant Abuse, HIV Prevention
Integrated BA and HIV RR Counseling for MSM With Stimulant Abuse
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the efficacy of Project IMPACT, an intervention that integrates Behavioral Activation (BA) with HIV risk reduction (RR) counseling for…
- Conditions
- Stimulant Abuse, HIV Prevention, Substance Abuse
- Trial name
- NCT03175159
- Testing
- IMPACT, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern
Cocaine Addiction
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence.
- Trial name
- NCT00729300
- Testing
- disulfiram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Cocaine Use Disorder
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
The purpose of this study is to evaluate semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in combination with cognitive behavioral therapy (CBT) for the treatment of cocaine use disorder (CUD).
- Trial name
- NCT07227948
- Testing
- Semaglutide, cognitive behavioral therapy (CBT).
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders
Infusion Laboratory: Protocol 5 (Flupenthixol) - 14
The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as…
- Trial name
- NCT00000349
- Testing
- Flupenthixol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Infusions, Intravenous
Cocaine-Metyrapone Interaction Study - 1
The purpose of this study is to examine the safety of two consecutive days of metyrapone (MRP) in subjects who may use cocaine concurrently.
- Trial name
- NCT00033098
- Testing
- Metyrapone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
GBR 12909 Study in Cocaine Experienced African American Volunteers - 1
The purpose of this study is to assess GBR 12909 in cocaine experienced African American Volunteers.
- Trial name
- NCT00089687
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
This is a residential pilot trial to evaluate the pharmacodynamic interaction between zonisamide and cocaine, with the goal of evaluating zonisamide's potential for the treatment of cocaine dependence.
- Trial name
- NCT01137890
- Testing
- Zonisamide, Cocaine Hydrochloride, Neurocognitive and Performance Battery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Impact of a Non-Drug Choice on Cocaine Reinforcement
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for…
- Trial name
- NCT01906346
- Testing
- Cocaine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cocaine Dependence
Clinical Trial of Topiramate for Cocaine Addiction
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment.
- Trial name
- NCT00685178
- Testing
- topiramate, Contingency Reinforcement
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cocaine-Related Disorders
Piracetam for Treatment of Cocaine Addiction, Phase II - 4
The purpose of this study is to follow patients in Phase I of an inpatient study in an eight week open label assessment of piracetam in an outpatient treatment program.
- Trial name
- NCT00000199
- Testing
- Piracetam
- Where
- United States
- Sponsor
- University of Pennsylvania