Clinical trials: Cocaine-related Disorders
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Abuse, Cocaine Dependence
Substance Abuse Pre-Treatment Screening Study
The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for…
- Conditions
- Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00439049
- Testing
- modafinil, d-amphetamine, L-Dopa
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders
Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3
The purpose of this study is to determine the effects of nefazedone on cocaine self-administration in depressed and non-depressed female cocaine users.
- Trial name
- NCT00000286
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the brain.
- Trial name
- NCT00134901
- Testing
- Memantine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Addiction, Cocaine Abuse
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine
The purpose of the study is to asses the potential interactions between intravenous cocaine and doxazosin in cocaine dependent volunteers who are not seeking treatment.
- Conditions
- Cocaine Addiction, Cocaine Abuse, Cocaine Dependence, Substance Abuse
- Trial name
- NCT01062945
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Cocaine Use Disorders
D-Cycloserine Facilitation of Cocaine - Cue Extinction
The purpose of this study is to explore the use of d-cycloserine (DCS) to facilitate extinction of response to cocaine cues in cocaine-dependent individuals, in hopes that it may lead to the development of new treatment options…
- Trial name
- NCT00759473
- Testing
- D-Cycloserine (DCS)
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders, Opioid-Related Disorders
Combining Behavioral Treatment With Agonist Maintenance - 1
The purpose of this study is to evaluate whether the community reinforcement approach (CRA) plus contingency management (CM) is more effective overall than CRA only in reducing illicit opioid and cocaine use during agonist…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000311
- Testing
- Buprenorphine, methadone
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Yale University
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Methylphenidate Treatment for Cocaine Abuse and ADHD - 1
Many cocaine dependent individuals are also diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Methylphenidate (Ritalin) is currently approved to treat individuals diagnosed with ADHD.
- Trial name
- NCT00136734
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence - 4
The purpose of this study is to empirically test a series of medications to: 1) determine each medication's efficacy in treatment of cocaine abuse/dependence; 2) find most effective dose range for each medication.
- Trial name
- NCT00000301
- Testing
- Amantadine
- Where
- United States
- Sponsor
- University of California, Los Angeles
Cocaine-Related Disorders
Treatment With Transcranial Magnetic Stimulation for Cocaine Addiction: Clinical Response and Functional Connectivity.
The purpose of this study is to investigate the short and long term clinical and cognitive effects of repetitive Transcranial Magnetic Stimulation (rTMS) at 5 Hz and/or 10 Hz frequencies on the left dorsolateral prefrontal cortex…
- Trial name
- TMS_COC_CONN (NCT02986438)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
HIV, AIDS
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
This study will evaluate the efficacy of an integrated "Retention Clinic" in achieving virologic suppression among HIV-infected cocaine (including crack) users by using a two-group randomized, prospective trial.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- NCT01614106
- Testing
- Retention Clinic
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cocaine Dependence
Modafinil for Smoked Cocaine Self-Administration
Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied.
- Trial name
- NCT01778010
- Testing
- Modafinil 0 mg, Modafinil 200 mg, Modafinil 400 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Substance-Related Disorders
Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder
This is a randomized, double-blind, placebo-controlled phase 2b pilot clinical trial to determine whether non-ergoline D3/D2/D1 dopamine (DA) receptor agonist rotigotine (RTG), in combination with treatment as usual, including…
- Trial name
- NCT05886582
- Testing
- Rotigotine Transdermal System [Neupro]
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence, Substance-induced Sleep Disorder
Modafinil, Sleep, and Cognition in Cocaine Dependence
Subjects participating in this protocol will participate in three phases: 1) pre-admission, 2) inpatient admission, and 3) follow-up.
- Conditions
- Cocaine Dependence, Substance-induced Sleep Disorder, Substance-induced Cognitive Disorder
- Trial name
- NCT00582491
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Tryptophan and Behavior Therapy for Cocaine Abuse - 1
The purpose of this study is to assess the efficacy of tryptophan vs. placebo, and voucher payments vs. a control condition, in the treatment of cocaine dependence.
- Trial name
- NCT00000324
- Testing
- Tryptophan
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Cocaine Use Disorder
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
The purpose of this study is to see how well pioglitazone, when used with cognitive behavioral therapy, works at helping people who have recently stopped using cocaine to continue to not use cocaine.
- Trial name
- NCT04843046
- Testing
- Cognitive Behavioral Therapy (CBT), Pioglitazone
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence, Opioid Dependency
Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients
Concurrent dependence on cocaine occurs in up to 50% of the over one million opiate dependent patients in spite of methadone maintenance treatment being highly effective for opiate dependence and having excellent treatment…
- Trial name
- Keppra-DB (NCT00577005)
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Cocaine Dependence
Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.
This proposal describes a combined laboratory and clinical trial preliminary investigation to advance medication development for cocaine dependence.
- Trial name
- NCT02255357
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute