Clinical trials: Cocaine-related Disorders
Cocaine-Related Disorders
Effects of Labetalol on Human Cocaine Use - 8
The purpose of this study is to determine the effect of labetalol treatment on the subjective and physiological effects of cocaine.
- Trial name
- NCT00000291
- Testing
- Labetalol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Pharmacogenetics of Doxazosin for Cocaine Dependence
Doxazosin, an alpha 1-adrenergic receptor antagonist, may play an important role in cocaine addiction in humans. This study will evaluate to what extent the prospective screening for catecholamine related polymorphisms for alpha…
- Trial name
- NCT01145183
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Methylphendidate Treatment of Cocaine Dependent Patients With Attention Deficit Hyperactivity Disorder - 3
The purpose of this study is to demonstrate the feasibility of methylphenidate (MPD) as effective and safe in the outpatient treatment of cocaine-dependent patients with a comorbid DSM-IV diagnosis of Attention Deficit…
- Trial name
- NCT00015054
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Addiction
Treating the Partners of Drug Using Pregnant Women: Stage II
This is a two group randomized design that will compare a novel therapy package (i.e., Research supported treatment intervention, Contingency-based voucher incentives for the male partner's drug abstinence, Specialized MI couples…
- Trial name
- HOPE (NCT00496990)
- Testing
- Enhanced care, control
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Johns Hopkins University
Cocaine-Related Disorders
Neurocircuit Strategy to Decrease Cocaine Cue Reactivity
The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.
- Trial name
- COCA (NCT04155632)
- Testing
- N-acetylcysteine, Theta-burst stimulation (TBS)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Risperidone Treatment in Dually-Diagnosed Individuals - 2
The purpose of this study is to evaluate the safety and efficacy of risperidone for cocaine dependence in individuals with schizophrenia/schizoaffective illness.
- Trial name
- NCT00000267
- Testing
- Risperidone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder
Smoking Cessation Treatment for Substance Use Dependents
The present research project aims to develop an innovative and empirically validated intervention protocol for smoking cessation among patients with substance use disorders (SUDs).
- Trial name
- NCT03551704
- Testing
- CBT + EFT, CBT + EFT + CM
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Oviedo
Cocaine Dependence, Alcoholism
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol and cocaine dependence.
- Trial name
- NCT00167232
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Pennsylvania
Cocaine Abuse
ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine
The purpose of this study is to assess the safety and tolerability of ALKS33-BUP when administered to opioid-experienced cocaine abusers.
- Trial name
- NCT01366001
- Testing
- ALKS 33-BUP, ALKS 33
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Alkermes, Inc.
Alcohol-Related Disorders, Cocaine-Related Disorders
Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4
The purpose of this study is to evaluate naltrexone as an adjunct in alcoholic cocaine dependent patients; concurrent relapse prevention theory.
- Trial name
- NCT00000307
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Behavioral Treatment for Cocaine Dependent Women
To compare the efficacy of Community Reinforcement Approach (CRA) and 12-Step Facilitation (TSF) counseling and of voucher based reward therapy (VBRT) and a yoked, non-contingent voucher control (VC) for the treatment of cocaine…
- Trial name
- NCT00914381
- Testing
- Behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 145 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Cocaine Effects in Humans: Physiology and Behavior - 1
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving, in opiate-dependent cocaine…
- Trial name
- NCT00000200
- Testing
- Methadone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1
The purpose of this study is to confirm whether a blood level ""ceiling"" exists on desipramine effect in cocaine abuse.
- Trial name
- NCT00000245
- Testing
- Desipramine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cocaine Abuse
Modafinil - Escitalopram Study for Cocaine Dependence
The purpose of this study is to improve the efficacy of modafinil as a potential treatment for cocaine dependence.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01601730
- Testing
- Modafinil and Escitalopram, Modafinil, Escitalopram
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Baylor College of Medicine
Schizophrenia, Cocaine Dependence
A Double-Blind, Controlled Study of Aripiprazole in Co-Morbid Schizophrenia and Cocaine Dependence
The purpose of this study is to gather systematic clinical data on whether aripiprazole, a partial dopamine agonist, beneficially affects schizophrenia plus cocaine dependence subjects.
- Trial name
- NCT00737256
- Testing
- Aripiprazole, Perphenazine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Paul Saenger
Cocaine Use Disorders
D-Cycloserine Facilitation of Cocaine - Cue Extinction
The purpose of this study is to explore the use of d-cycloserine (DCS) to facilitate extinction of response to cocaine cues in cocaine-dependent individuals, in hopes that it may lead to the development of new treatment options…
- Trial name
- NCT00759473
- Testing
- D-Cycloserine (DCS)
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Naltrexone in Treatment of Cocaine Dependence - 5
The purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2) decreased cocaine use by self-report, 3) decreased…
- Trial name
- NCT00015080
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Selegiline in Treatment of Cocaine Dependence - 2
The purpose of this study is to assess selegiline as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000188
- Testing
- Selegiline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Modafinil for Smoked Cocaine Self-Administration
Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied.
- Trial name
- NCT01778010
- Testing
- Modafinil 0 mg, Modafinil 200 mg, Modafinil 400 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute