Clinical trials: Coccidioidomycosis Infection
Toxoplasmosis
Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects
Pyrimethamine in combination with a sulphonamide is known to be effective in the treatment of toxoplasmosis. However, Pyrimethamine has not been approved by the Japanese regulatory body (Pharmaceutical and Medical Devices Agency…
- Trial name
- NCT03258762
- Testing
- Pyrimethamine, Calcium folinate
- Where
- Australia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections, Cryptosporidiosis
Interleukin 12 (IL-12) for the Treatment of Cryptosporidiosis in AIDS Patients
There is no proven effective treatment for chronic diarrhea caused by the parasite Cryptosporidium in advanced AIDS. This trial will test the safety of interleukin-12 (IL-12) as part of a combination therapy for this parasite.
- Trial name
- NCT00057486
- Testing
- IL-12
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Toxoplasmosis, Rhd
Measuring the Prevalence of Toxoplasmosis and Its Socio-economic Consequences
The investigators propose a fast and inexpensive procedure to determine the prevalence of the Toxoplasmosis infection (Toxoplasma Gondii) in the general population, using response times in a cognitive task instead of costly…
- Trial name
- EconToxo (NCT05860998)
- Testing
- Presence of Toxoplasma gondii IgG Antibodies
- Volunteers
- 120 people
- Sponsor
- University of Zurich
HIV Infections, Cryptosporidiosis
Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children
Cryptosporidium parvum (C. parvum) is a parasite that can cause chronic diarrhea and is a significant problem for HIV infected children in developing countries. C. parvum infection can be treated with the drug nitazoxanide (NTZ).
- Trial name
- NCT00055107
- Testing
- Nitazoxanide
- Where
- 2 sites in South Africa, Thailand
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Meningitis, HIV Infections
Open, Non-Comparative Study of Fluconazole in Patients With Coccidioidal Meningitis
The study is intended to examine the efficacy of fluconazole for the treatment of coccidioidal meningitis in patients with new onset of infection, relapse of previous infection, or failed previous therapy.
- Trial name
- NCT00002010
- Testing
- Fluconazole
- Where
- 3 sites in United States
- Sponsor
- Pfizer
Cerebral Toxoplasmosis, AIDS
Cerebral Toxoplasmosis and AIDS
With a HIV incidence much higher in the DFA than in European French territory, this disease is a major public health problem in these areas, especially in French Guiana.
- Trial name
- TOXODFA (NCT00803621)
- Testing
- Toxoplasma PCR assay
- Where
- 5 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Limoges
Rift Valley Fever
Safety and Immunogenicity of a Candidate Rift Valley Fever Vaccine (RVF003)
The goal of this clinical trial is to learn if ChAdOx1 RVF, a candidate vaccine against RVF, provides an adequate immune response and determine its safety among Kenyan adults.
- Trial name
- RVF003 (NCT06799234)
- Testing
- ChAdOx1 RVF, Rabies Vaccine
- Where
- Kenya
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Colonic Neoplasms, Cryptosporidiosis
Cryptosporidium Infection and Human Colorectal Cancer
It has been reported that Cryptosporidium parvum, a species of a protozoan frequently isolated from humans and animals, is able to induce digestive adenocarcinoma in a rodent model.
- Trial name
- Crypto-K (NCT04332705)
- Testing
- Detection of Cryptosporidium infection
- Where
- France
- Volunteers
- 324 people
- Sponsor
- Lille Catholic University
Cryptosporidiosis, HIV Infections
Safety and Effectiveness of Nitazoxanide for the Treatment of Cryptosporidiosis in AIDS Patients
The purpose of this study is to see if it is safe and effective to treat cryptosporidiosis in AIDS patients with nitazoxanide.
- Trial name
- NCT00004986
- Testing
- Nitazoxanide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Romark Laboratories L.C.
Cryptosporidiosis, HIV Infections
A Study of Nitazoxanide in Patients With AIDS and Diarrhea Caused by Cryptosporidium
To determine the frequency of complete, marked, and partial clinical responses in patients with cryptosporidiosis treated with 6 weeks of NTZ versus 21 days of placebo.
- Trial name
- NCT00001081
- Testing
- Nitazoxanide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ocular Toxoplasmosis
Spectral Optical Coherence Tomography Findings in Patients With Ocular Toxoplasmosis
Ocular toxoplasmosis is the most common cause of infectious uveitis worldwide. The diagnosis of ocular toxoplasmosis is primarily clinical when it is a typical presentation .With an atypical presentation in the fundus…
- Trial name
- NCT04219176
- Testing
- Spectral optical coherence tomography
- Volunteers
- 9 people
- Sponsor
- Université de Sousse
Toxoplasmosis
Role of Circulating MicroRNAs in Differentiating Psychological Disorders Among Women With Chronic Toxoplasmosis
Chronic Toxoplasma gondii (T. gondii) infection is a widespread condition that can negatively affect brain function and is considered a risk factor for various psychiatric conditions, including depression and schizophrenia.
- Trial name
- NCT07346833
- Testing
- Circulating miRNA Expression and T. gondii Serology
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Benha University
Invasive Fungal Infections
Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options
A study to evaluate olorofim (F901318) for the treatment of invasive fungal infections in participants lacking suitable alternative treatment options.
- Trial name
- FORMULA-OLS (NCT03583164)
- Testing
- Olorofim
- Where
- 82 sites in United States, Australia and 15 more
- Volunteers
- 203 people
- Sponsor
- F2G Biotech GmbH
Cryptosporidiosis, HIV Infections
A Study of Spiramycin in the Treatment of Patients With AIDS-Related Diarrhea
To determine the safety and effectiveness of intravenous spiramycin in patients with AIDS-related cryptosporidial diarrhea. Spiramycin, a macrolide antibiotic, has been studied in the United States for the treatment of…
- Trial name
- NCT00000980
- Testing
- Spiramycin
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Rhone-Poulenc Rorer
Coccidioidomycosis
Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment
The purpose of this study is to determine if nikkomycin Z is safe when administered at different dose levels for 14 days. The study will also determine blood levels and urinary excretion of nikkomycin Z in relation to dose…
- Trial name
- NCT00614666
- Testing
- nikkomycin Z
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Arizona
RVF, Rift Valley Fever
A Study to Assess the New Candidate Rift Valley Fever Virus Vaccine in Healthy Adults
Randomised, single blind, placebo - controlled, dose-escalation, phase I clinical trial recruiting healthy adults aged 18-50 years
- Trial name
- NCT04672824
- Testing
- ChAdOx1 RVF, Saline
- Where
- Uganda
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Valley Fever, Coccidioidomycosis
Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment
This will be a multi-visit study that will take approximately 3 hours in total. Up to 200 subjects from the BUMC Valley Fever and BUMC Dermatology clinics will be enrolled in this study and assigned to one of three cohorts…
- Trial name
- NCT03618992
- Testing
- Cholesterol-containing moisturizers
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Arizona
HIV Infections, Tuberculosis
Prevalence of HIV +ve Cases With AIDS Defining Opportunistic Infections Among ART Naive Patients Attending ART Centre
HIV patients are likely to suffer from opportunistic infections, in absence of highly active retroviral therapy. This happens due to lack of awareness of HIV status among patients or unresponsive to anti retroviral drugs.
- Conditions
- HIV Infections, Tuberculosis, Candidiasis, Esophageal, Cryptococcosis
- Trial name
- ADC (NCT03993093)
- Testing
- CD4 cell count
- Where
- India
- Volunteers
- 257 people
- Sponsor
- Singh, Ranjan Kumar, M.D.
HIV, PCP
Antiretroviral Drug Interaction Study in Volunteers With HIV
Background: People who are infected with the human immunodeficiency virus (HIV) are at risk of getting certain diseases. Two of these diseases are a type of pneumonia known as PCP and a brain infection called toxoplasmosis.
- Conditions
- HIV, PCP, Toxoplasmosis
- Trial name
- NCT01479361
- Testing
- Atovaquone 750 mg twice daily, Atovaquone 1500 mg twice daily
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Congenital Toxoplasmosis
Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis
Toxoplasmosis is a benign disease in healthy adults, but can be serious in the case of contamination during pregnancy: the parasite can pass through the placental barrier and infect the foetus.
- Trial name
- TOSCANE (NCT01202500)
- Testing
- reducing treatment to 3 months, registered length of treatment
- Where
- France
- Volunteers
- 302 people
- Sponsor
- Centre Hospitalier Universitaire Dijon