Clinical trials: Coeliac Disease
Celiac Disease
A Study of TAK-062 in Treatment of Active Celiac Disease in Participants Attempting a Gluten-Free Diet
The main aim is to see how TAK-062 works to reduce celiac-related symptoms and improve small intestinal damage due to gluten exposure, in participants with celiac disease (CeD) attempting to maintain a gluten-free diet (GFD) in…
- Trial name
- NCT05353985
- Testing
- TAK-062, Simulated Inadvertent Gluten Exposure (SIGE) Gluten-Bar, Simulated Inadvertent Gluten Exposure (SIGE) Gluten-free Bar
- Where
- 102 sites in United States, Belgium and 6 more
- Volunteers
- 153 people
- Sponsor
- Takeda
Celiac Disease, Iron Deficiency Anemia
Sucrosomial Iron in Patients With Celiac Disease and IDA
Sucrosomial iron (Sideral® Forte) is a preparation of ferric pyrophosphate conveyed within a phospholipid membrane associated with ascorbic acid, is a new-generation oral iron which shows a high gastrointestinal absorption and…
- Trial name
- NCT02916654
- Testing
- sucrosomial iron, Sulphate iron
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Non-celiac Wheat Sensitivity
Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have CD or wheat allergy.
- Trial name
- NCT03017274
- Testing
- Abdominal ultrasound examination
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Gluten Intolerance
Development of a Celiac Safe Food Additive
The goal of this clinical trial was to investigate if intestinal deamidation of gliadin from wheat bread could be hindered by adding a E304i/zinc additive.
- Trial name
- NCT06005376
- Testing
- Breakfast rolls consisting of wheat flour with and without a E304i/zinc additive
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chalmers University of Technology
Pancreatitis, Chronic, Abdominal Pain
Clinical Trial to Evaluate the Endoscopic Ultrasound Guided Celiac Plexus Block for Treatment of Pain in Chronic Pancreatitis
AIM: To compare pain relief in patients randomly assigned to endoscopic ultrasound-guided celiac ganglia block (EUS-CGB) vs standard endoscopic ultrasound-guided celiac plexus block (EUS-CPB).
- Trial name
- NCT03070210
- Testing
- EUS-celiac ganglia block (EUS-CGB), EUS-celiac plexus block (EUS-CPB)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Cleveland Clinic
Mesenteric Ischemia, Median Arcuate Ligament Syndrome
Coeliac Artery Release or Sham Operation
In patients with Median Arcuate Ligament Syndrome (MALS), significant external compression of the coeliac artery (CA) by the median arcuate ligament (MAL) increasing mucosal ischemia (1,2) is assumed to cause chronic disabling…
- Conditions
- Mesenteric Ischemia, Median Arcuate Ligament Syndrome, Dunbar Syndrome, Coeliac Artery Compression
- Trial name
- CARoSO (NCT05468580)
- Testing
- Endoscopic Coeliac Artery Release (eCAR)
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Medisch Spectrum Twente
Celiac Disease
Coeliac Disease in Spain: Determination of Disease Prevalence and Risk Factors
Previous studies have showed that Coeliac Disease (CD) prevalence is significantly higher in children compared with adults. The largest epidemiologic study carried out in Spain to date (n=4230) reported a higher CD prevalence in…
- Trial name
- NCT05094232
- Where
- Spain
- Volunteers
- 4,826 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Coeliac Disease, Probiotic
Efficacy of Symprove Probiotics in Coeliac Disease
Coeliac Disease (CD) is a lifelong autoimmune condition where eating gluten (a protein found in wheat, barley, and rye) causes damage to the small intestine. It affects around 1 in 100 people.
- Conditions
- Coeliac Disease, Probiotic, Gluten
- Trial name
- NCT07360106
- Testing
- Symprove Probiotic
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Celiac Disease
Rifaximin for the Treatment of Persistent Symptoms in Patients With Celiac Disease
Celiac disease is a condition in which the small intestine is damaged by gluten, the storage protein of wheat and similar proteins in barley and rye.
- Trial name
- NCT01137955
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Celiac Disease
Assessment of Coeliac Disease in Patients With Type 2 Diabetes
This study aims to screen and diagnose coeliac disease in patients with type 2 diabetes and monitor the effect of gluten-free diet on the metabolic status
- Trial name
- NCT06283264
- Volunteers
- 100 people
- Sponsor
- Assiut University
Celiac Disease
Evaluating the Efficacy and Tolerability of ZED1227 in Subjects With Non-responsive Celiac Disease
A study to discover if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
- Trial name
- CEC-013/CEL (NCT07298343)
- Testing
- ZED1227 + SIGE
- Where
- Germany
- Volunteers
- 356 people
- Sponsor
- Dr. Falk Pharma GmbH
Celiac Disease, Gluten
HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease
The investigators will evaluate the use of an HLA-DQ2-gliadin tetramer for staining of gluten specific T cells in the diagnostics of uncertain celiac disease.
- Trial name
- NCT01100099
- Testing
- Gluten challenge.
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Celiac Disease in Children
Prevention of Celiac Disease in Skåne
This study aims to investigate the impact of being on a gluten free diet the first three years of life compared to a daily intake of a probiotic supplementation or placebo on the risk of developing celiac disease autoimmunity or…
- Trial name
- PreCiSe (NCT03562221)
- Testing
- Gluten free diet, Probiotics
- Where
- Sweden
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Lund University
Celiac Disease
Impact of a Low-FODMAP Gluten-free Diet on Gut Microbiota and Circulating miRNAs in Celiac Disease Patients
15 patients with refractory celiac disease (RCD) and 15 patients with CD responsive to the GFD between the ages of 21 and 60 will be enrolled.
- Trial name
- FODMAP2019 (NCT04655495)
- Testing
- Low FODMAPs /balanced gluten free diet
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Celiac Disease
Safety of Prolonged Administration of Triticum Monococcum in Celiac Disease
Preliminary studies on safety profile of Triticum Monococcum (Tm, a variety of Ancient Wheat) have provided conflicting results with some in vitro and ex vivo studies consistent with non toxicity and other suggestive of toxicity.
- Trial name
- NCT02220166
- Testing
- Triticum monococcum
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Università degli Studi di Brescia
Celiac Disease
Tissue Destruction and Healing in Celiac Disease
The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells…
- Trial name
- NCT05680012
- Testing
- Gluten containing snack bar
- Where
- 3 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Unidentified Gastrointestinal Symptoms Following Gluten-free Oats Consumption
Gluten-free Oats and Gastrointestinal Health in Coeliac Disease, Part 2
The research aims to investigate the effects of gluten-free oats to the gastrointestinal health in celiac disease patients and healthy subjects.
- Trial name
- NCT02761785
- Where
- Finland
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Turku
Celiac Disease
Study of the Safety, Tolerability, Pharmacokinetics and Biomarker of DONQ52 in Celiac Disease Patients
This study is to characterize the safety and tolerability of an investigational drug called DONQ52 and consists of a single ascending dose part (Part A) and a multiple ascending dose part (Part B) in well-controlled celiac…
- Trial name
- NCT05425446
- Testing
- DONQ52
- Where
- 21 sites in United States, Australia
- Volunteers
- 56 people
- Sponsor
- Chugai Pharmaceutical
Crohn's Disease, Short Bowel Syndrome
Citrulline: A Plasmatic Marker to Assess and Monitor Small Bowel Crohn's Disease Patients
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Crohn's Disease, Short Bowel Syndrome, Malabsorption Syndromes, Celiac Disease
- Trial name
- NCT00138879
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- St Mark's Hospital Foundation
Celiac Disease Patients Following Recommendations of ESPGHAN, HLA-DQ2 Typing Include HLA-DR7-DQ2 Haplotypes
Clinical Relevance of Typing HLA-DR7-DQ2
Celiac disease patients with HLA-DR7-DQ2 haplotype have the same histological, analytical and clinical behaviour as patients with HLA-DR3-DQ2 haplotype.
- Trial name
- HLA (NCT01813383)
- Testing
- There is not any intervention
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Corporacion Parc Tauli