Clinical trials: Coeliac Disease
Pancreatic Cancer
Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN)With Alcohol in Unresectable Pancreatic Cancer: a Pilot Study
The purpose of this study is to obtain preliminary safety and efficacy data after endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) in patients with locally advanced or unresectable pancreatic adenocarcinoma.
- Trial name
- NCT00578279
- Testing
- dehydrated alcohol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Pain, Postoperative, Nerve Block
Application of Celiac Plexus Block in Postoperative Analgesia of Whipple Surgery
This subject intends to explore the value of intraoperative celiac plexus block in postoperative acute pain management and its promoting effect on patients' rapid recovery during Whipple surgery through a randomized controlled…
- Trial name
- NCT05205720
- Testing
- Celiac plexus block, Ropivacaine
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Cancer
EUS Guided Neurolysis Celiac Block w/wo Bupivacaine in Patient Being Treated Palliatively for Pancreatic Cancer
The goal of this project is to determine if EUS-CPN without Bupivacaine (versus EUS-CPN with Bupivacaine) can reduce pain scores and improve quality of life in patients with inoperable pancreatic cancer by reducing the morbidity…
- Trial name
- EUS-CPN (NCT02682082)
- Testing
- Endoscopic ultrasound-guided celiax plexus neurolysis, Bupivacaine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Celiac Disease
PRV-015 in Gluten-free Diet Non-responsive Celiac Disease
This study will evaluate the efficacy and safety of PRV-015 in adult patients with non-responsive celiac disease (NRCD) who are on a gluten-free diet (GFD).
- Trial name
- PROACTIVE (NCT04424927)
- Testing
- PRV-015
- Where
- 38 sites in United States, Canada and 2 more
- Volunteers
- 388 people
- Sponsor
- Provention Bio, a Sanofi Company
Celiac Disease
Evaluation of Patient Reported Outcome Instruments in Celiac Disease Patients
This is an evaluation of celiac-specific patient reported outcome instruments in celiac disease patients.
- Trial name
- NCT01560169
- Where
- 10 sites in United States, Canada
- Volunteers
- 110 people
- Sponsor
- Alvine Pharmaceuticals Inc.
Pancreatitis, Chronic
Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis
The purpose of this study is to determine if celiac bloc (with injection of steroid and local anesthetic) is superior to a sham procedure for pain control and quality of life improvement in patient with chronic pancreatitis and…
- Trial name
- NCT01318590
- Testing
- EUS procedure with drug injection, EUS procedure
- Where
- 2 sites in Belgium, Canada
- Volunteers
- 2 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Helicobacter Pylori Infection, Celiac Disease
Assessing the Histological Quality of Biopsy Samples Obtained With Multibite Forceps
Biopsies are routinely taken during endoscopy and colonoscopy in order to facilitate histological analysis of various disease processes.
- Trial name
- NCT05227079
- Testing
- MultCROC multibite forcep, Conventional double bite forcep
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Lawrence Charles Hookey
Celiac Disease
Behavioral Intervention for Celiac Disease
Celiac disease (CD) is a chronic autoimmune condition whose only currently available treatment is a strict, burdensome gluten-free diet (GFD).
- Trial name
- NCT05204446
- Testing
- GROW Project, GROW+ Project
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Children's National Research Institute
Cancer
Radiofrequency Splanchnic Denervation ,Neurolytic Retrocrural Celiac Plexus Block Chronic Upper Abdominal Cancer Pain
To compare between the efficacy of radiofrequency splanchnic denervation and neurolytic retrocrural celiac plexus block in chronic upper abdominal cancer pain
- Trial name
- NCT06678061
- Testing
- radiofrequency
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
The Objective is to Confirm the Role of Gluten in Triggering the Digestive and Extradigestive Symptoms of NCGS
GlutN : Randomized, Double-blind, Crossover Clinical Trial to Confirm the Role of Gluten in Non-celiac Gluten Sensitivity
For 25 years, non-celiac gluten sensitivity (NCGS) has been the subject of very prolific and confusing scientific literature. This clinical entity is defined by the appearance of digestive and extradigestive symptoms in the…
- Trial name
- GLUTN (NCT06347341)
- Testing
- Clinical study comparing a gluten-containing diet to a gluten-free diet
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Celiac Disease, Autoimmune Enteropathy
Pathogenic Study of Adult Immune Enteropathies
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced…
- Conditions
- Celiac Disease, Autoimmune Enteropathy, Inflammatory Bowel Diseases
- Trial name
- ENTEROPATH (NCT04280510)
- Testing
- Blood sample collection; gastrointestinal biopsy
- Where
- 4 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Abdominal Cancer, Cancer Pain
Permanent Celiac Plexus Block: Comparison of Pain Score in Unilateral and Bilateral Posterior Percutaneous Approach
The goal of this prospective, interventional, non-randomized study was to compare pain score in unilateral and bilateral posterior percutaneous neurolytic celiac plexus block (NCPB) in upper abdominal cancer patients.
- Conditions
- Abdominal Cancer, Cancer Pain, Cancer of Pancreas
- Trial name
- NCT06316908
- Testing
- Unilateral Neurolytic Celiac Plexus Block with Absolute Alcohol, Bilateral Neurolytic Celiac Plexus Block with Absolute Alcohol
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Sindh Institute of Urology and Transplantation
Tryptophan Metabolism Alterations, Celiac Disease
Tryptophan for Impaired AhR Signaling in Celiac Disease
This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD)…
- Trial name
- TIARSCeD (NCT05576038)
- Testing
- L-Tryptophan, Freedom SimpleCap Powder
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Celiac Disease
Effects of Omega-3 Fatty Acids on Inflammation and Gut Microbiota in Celiac Disease
The goal of this clinical trial is to learn if omega-3 fatty acid supplements (n-3 PUFAs) can help reduce inflammation and promote intestinal healing in adults newly diagnosed with celiac disease (CD).
- Trial name
- OMEGA-CD (NCT07585669)
- Testing
- n-3 Polyunsaturated Fatty Acids (PUFAs)
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Diabetes, Celiac Disease
Gfree - For Improved Blood Sugar and Reduced Inflammation.
The goal of this clinical trial is to reduce inflammation and improve glycemic control in healthy volunteers, parents, as well as children, adolescents and adults with or without diabetes.
- Conditions
- Diabetes, Celiac Disease, Autoimmunity, Metabolic Disease
- Trial name
- NCT05894746
- Testing
- gluten-free, probiotic, gluten
- Where
- 2 sites in Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Celiac Disease
Gluten Challenge in Celiac Disease
Up till 30 participants with celiac disease on a glutenfree diet are asked to consume gluten containing cookies or bread for 3 days. Questionnaires and sampling of blood is done before, during and after.
- Trial name
- NCT02464150
- Testing
- Gluten challenge
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Oslo University Hospital
Celiac Disease, Dentin Hypersensitivity
Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients
This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel…
- Conditions
- Celiac Disease, Dentin Hypersensitivity, Tooth Demineralization
- Trial name
- CELIADENT (NCT07069127)
- Testing
- Biorepair Toothpaste and Mousse, Biorepair® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Not-celiac Gluten (Wheat) Sensitivity
Bioelectrical Impedance Analysis of Not-celiac Wheat Sensitivity Patients
Aim of the investigators' study is to evaluate one of the symptoms described by patients affected with the so-called "not-celiac wheat sensitivity" (NCWS).
- Trial name
- NCT01762566
- Testing
- wheat, xylose
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Celiac Disease
Effects of Kefir on Celiac Disease
This study will investigate whether regular consumption of kefir can reduce gastrointestinal symptoms and improve quality of life in adults with celiac disease who follow a strict gluten-free diet.
- Trial name
- CeliKef (NCT07777666)
- Testing
- kefir
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Maribor
Eosinophilic Esophagitis, Celiac Disease
Dose Escalation Study to Evaluate an Experimental New Treatment (CALY-002) in Healthy Subjects and Subjects With Celiac Disease and Eosinophilic Esophagitis
This is a single and multiple ascending study to characterize the safety, PK, PD and clinical effect in healthy volunteers and participants with Celiac Disease and Eosinophilic Esophagitis.
- Trial name
- NCT04593251
- Testing
- CALY-002
- Where
- 13 sites in Belgium, Finland and 3 more
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Calypso Biotech BV