Clinical trials: Cognition, open to volunteers
Cognition
Targeted Assessment of Cognition and Tactical-performance With Ingested Ketones
The goal of this study is to determine whether consuming a commercially available exogenous ketone supplement (KetoneIQ®) affects cognition, specifically marksmanship, under physical stress (i.e., exhaustive exercise).
- Trial name
- TACTIK (NCT07771790)
- Testing
- KetoneIQ®
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy Aging, Cognition
Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study
This pilot study aims to investigate the effects of a single oral dose of cannabidiol (CBD) on memory and attention in healthy adults aged 60 to 70 years.
- Trial name
- CBD-MAP (NCT07910292)
- Testing
- Cannabidiol (CBD)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Diabetes Mellitus, Microbiome
Supplementation of Inulin + L. Acidophilus in Elders With T2DM
This study investigates the effects of a symbotic supplement (Inulin + Lactobacillus acidophilus) on cognitive impairment in older adults with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Mellitus, Microbiome, Cognition Disorders
- Trial name
- NCT06830824
- Testing
- Lactobacillus acidophilus
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Cognition, Healthy Volunteers
Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cognition, Dual-Task Performance, and Interoceptive Accuracy
This study aims to determine the simultaneous effects of transcutaneous auricular vagus nerve stimulation (taVNS) at two frequencies (30 Hz and 100 Hz) compared to sham stimulation on cognitive functions, dual-task performance…
- Trial name
- NCT07897175
- Testing
- taVNS 30 Hz, taVNS 100 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Toros University
Gulf War Illness, Chronic Fatigue
Ca-Mg Butyrate in Gulf War Illness
The primary objective of this clinical trial is to determine if treatment with Butyrate formulation that consists of butyric acid as calcium and magnesium derivatives (Ca-Mg Butyrate) improves the physical function of men and…
- Conditions
- Gulf War Illness, Chronic Fatigue, Neurocognitive Dysfunction
- Trial name
- Butyrate (NCT05367245)
- Testing
- Cal-Mag Butyrate
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Autism, Intervention (Training) Condition
Parent-Mediated Social Cognition Intervention for Young Children With Autism Spectrum Disorder
This study evaluates the efficacy of the Companion Mind-Drawing Cooperative Game Program, a parent-mediated, home-based structured play intervention targeting social cognitive development in young children with autism spectrum…
- Conditions
- Autism, Intervention (Training) Condition, Social Cognition, Cognition Improvement
- Trial name
- PMSC-ASD (NCT07708246)
- Testing
- Companion Mind-Drawing Cooperative Game Program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Neurofibromatosis 1 (NF1), Executive Function (Cognition)
Cognitive Intervention for Children and Adolescents With NF1
Psychological interventions have been shown to be effective for managing cognitive and mental health challenges in different patient populations.
- Conditions
- Neurofibromatosis 1 (NF1), Executive Function (Cognition), Cognitive Intervention
- Trial name
- NCT07869914
- Testing
- Unstuck and On Target!
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Socioemotional Development, Physical Activity
Newenkantun: a Play-based Program to Promote Socioemotional Learning in Early Childhood Education in Chile.
What is this study about? This study will test a program called "Newenkantun" (which refers to a hand-strength game in Mapuche culture) designed to help young children develop important social and emotional skills through play…
- Conditions
- Socioemotional Development, Physical Activity, Sleep, Motor Skills
- Trial name
- Newenkantun (NCT07871929)
- Testing
- Teacher Professional Development, Parent/guardian support, Play-Based Activities and Environmental Modifications
- Where
- 2 sites in Chile
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Cognitive Dysfunction, Lewy Body Disease
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
The main purpose of this study is to evaluate whether treatment with donanemab slows the progression of cognitive (how we think, learn, remember, pay attention, and make decisions) and functional (how we are able to perform daily…
- Conditions
- Cognitive Dysfunction, Lewy Body Disease, Synucleinopathies, Amyloid
- Trial name
- NCT07589595
- Testing
- Donanemab
- Where
- 72 sites in United States, Japan and 2 more
- Volunteers
- 350 people
- Sponsor
- Eli Lilly and Company
Parkinson Disease (PD), Cognition
Short Term Effects of a Multimodal Intervention With RGM on Cognition in People With Parkinson's Disease.
The goal of this clinical trial is to learn if the Ronnie Gardiner Method (RGM) works to improve cognitive functions in adults with Parkinson's disease (early to mid-stage).
- Conditions
- Parkinson Disease (PD), Cognition, Quality of Life, Functional Mobility
- Trial name
- NCT07863219
- Testing
- Ronnie Gardiner Method
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Ghent
Multiple Sclerosis, Pilates Exercise
The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis
Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.
- Conditions
- Multiple Sclerosis, Pilates Exercise, Walking, Balance
- Trial name
- MS (NCT07504120)
- Testing
- Pilates
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Social Cognition, Personality Disorder
Neurocomputational Dynamics of Cooperation
The purpose of this study is to understand brain function, how people make decisions when they interact with others, and how brain function and behavior relate to personality traits.
- Conditions
- Social Cognition, Personality Disorder, Mental Health, Interpersonal Conflict
- Trial name
- COBRA (NCT07759973)
- Testing
- Social Learning Task Battery, Clinical Cohort, Social Learning Task Battery, Online Cohort
- Where
- United States
- Volunteers
- 1,612 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Emotional Processing, Cognition
7T Amygdala and Citalopram Study
The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds…
- Conditions
- Emotional Processing, Cognition, Mood Disorders, Depressive Disorder
- Trial name
- 7T FACES (NCT06412315)
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Mild Cognitive Impairment, Alzheimer Disease
Alzheimer's Disease Neuroimaging Initiative 4
The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- ADNI4 (NCT05617014)
- Testing
- Neuraceq, Amyvid, Tauvid
- Where
- 65 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
Psilocybin Microdosing on Cognition, Mood and Quality of Life
This study is being conducted to evaluate how of 30 days of intermittently microdosed psilocybin affects mood, cognition, subjective well-being and structural/functional MRI results compared to a placebo.
- Trial name
- NCT07449351
- Testing
- Psliocybin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Multiple Sclerosis, High-intensity Interval Training
The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis
This study aims to comparatively investigate the effects of low-volume High-Intensity Interval Training (HIIT) versus Moderate-Intensity Continuous Training (MICT) on gait, balance, cognitive functions, and neurovascular…
- Conditions
- Multiple Sclerosis, High-intensity Interval Training, Gait, Balance
- Trial name
- HIIT-MS (NCT07578740)
- Testing
- Moderate-Intensity Continuous Training (MICT), High-Intensity Interval Training (HIIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Dystrophinopathies
Decoding Central Defects in Dystrophinopathies From Diagnostic to Remediation
The study aims to identify a genotype/phenotype correlation by analyzing more finely the neurodevelopmental disorders in DMD patients.
- Trial name
- DECODYS (NCT07125898)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Injury, Cognition
Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD
Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage…
- Conditions
- Brain Injury, Cognition, PTSD, Intervention
- Trial name
- NCT05380050
- Testing
- Goal Management Training plus Attention Training, Brain Health Workshop and National Geographic Movies
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Cognition, Parkinson's Disease
Dual-Task Balance and Gait Training Combined With Cognitive Training in Parkinson's Patients
The aim of the study is to examine the effects of a structured, cognitive dimension-specific cognitive training combined with dual-task balance and gait training on balance, gait, and cognition in individuals with Parkinson's…
- Conditions
- Cognition, Parkinson's Disease, Gait Disorders, Neurologic, Balance Disorders
- Trial name
- NCT07213232
- Testing
- Core Stability Training, Dual-Task Balance and Gait Training, Cognitive Training
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Gazi University