Clinical trials: Cognition Disorder
Memory Disorders, Age-Related Cognitive Decline
Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint
As recommended allowance of oral vitamine D are unable to ensure the recommended serum concentration of vitamine D, the purpose of this study is to show that a dose of vitamin D3 higher than the recommended allowance may slow the…
- Trial name
- D-COG (NCT02185222)
- Testing
- Cholecalciferol 100 000 UI
- Where
- 11 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Tours
Neurodegenerative Diseases
Pilot Study About Extra Virgin Olive Oil "Coratina" in Mild Cognitive Impairment and Alzheimer's Disease Patients
Alzheimer's Disease is a neurodegenerative disease age related caused by neurofibrillary tangles misfolding and Beta-amyloid protein accumulation.
- Trial name
- EVOCAD (NCT04229186)
- Testing
- EVOO-C, ROO
- Volunteers
- 24 people
- Sponsor
- University of Bari Aldo Moro
Transcranial Magnetic Stimulation, Complex Regional Pain Syndrome of Upper Limb (Disorder)
CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation
This is a sham controlled, randomized, double-blind, navigated repetitive Transcranial Magnetic Stimulation (nrTMS) study for the treatment of complex regional pain syndrome (CRPS types 1 and 2).
- Trial name
- NCT04439669
- Testing
- Active nrTMS and open phase
- Where
- 2 sites in Finland
- Volunteers
- 62 people
- Sponsor
- Helsinki University Central Hospital
HIV, Mild Neurocognitive Disorder
Cognitive Training With and Without tDCS to Improve Cognition in HIV
The purpose of this study is to develop pilot data on the potential efficacy of computer-based cognitive training or the combination of computer-based cognitive training with transcranial direct current stimulation (tDCS) in…
- Trial name
- NCT02647645
- Testing
- Transcranial direct current stimulation, Cognitive training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Nova Southeastern University
ALS, Amyotrophic Lateral Sclerosis
Speech Analysis in ALS Patients
The purpose of this study is to find out if changes in speech can signal changes in the ability to think or remember. ALS patients with and without cognitive dysfunction will be followed for one year.
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Lou Gehrig Disease
- Trial name
- NCT03868345
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Barrow Neurological Institute
Autism, Major Depressive Disorder (MDD)
Investigating the Brain's Physiological Responses in Depression and Autism, Using Transcranial Magnetic Stimulation and Electroencephalography
The goal of this observational study is to investigate the brain physiological responses in depression and autism. The main questions aim to answer are: 1.
- Trial name
- NCT06821646
- Testing
- Positron Emission Tomography (PET), transcranial magnetic stimulation and electroencephalography(TMS-EEG)
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Immune Thrombotic Thrombocytopenia
Impact of Acute ITTP Therapies on Long Term Neurologic and Cognitive Outcomes in ITTP Survivors
1. We expect to find that the silent cerebral infarct (SCI) rate is two fold higher in patients treated without caplacizumab. We also expect to find that the rate of mild and major cognitive impairment in patients treated with…
- Trial name
- NeST (NCT06358703)
- Testing
- Caplacizumab
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- US Thrombotic Microangiopathy Alliance
Dementia, Cognitive Impairment
Prevalence and Recognition of Geriatric Syndrome in Outpatient Clinic at Srinagarind Hospital
The purpose of this study is to collect the prevalence of geriatric syndrome, which is recognized by an internist, and to compare the data based on the comprehensive geriatric assessment by a geriatrician.
- Conditions
- Dementia, Cognitive Impairment, Depression, Urinary Incontinence
- Trial name
- NCT00892086
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Mild Cognitive Impairment (MCI)
Effect of Inspiratory Muscle Training in Cognition
The goal of this clinical trial is to examine the effect of a respiratory muscle strengthening program on the cognitive and physical functioning of patients with neurocognitive disorders (Mild Cognitive Impairment) or those…
- Trial name
- NCT07146373
- Testing
- Inspiratoty Muscle training, Usual Care
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- University of West Attica
Alzheimer Disease, Dementia
Ultrasonic Neuromodulation for Treatment of Cognitive Impairment
This study will evaluate a new form of non-invasive deep brain therapy for individuals with Alzheimer's disease. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation…
- Conditions
- Alzheimer Disease, Dementia, Cognitive Impairment
- Trial name
- NCT06135051
- Testing
- Diadem prototype
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Neuroinflammation in Cognitive Decline Post-cardiac Surgery
Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing.
- Conditions
- Postoperative Cognitive Dysfunction, Coronary Artery Disease, Pathophysiology
- Trial name
- FOCUS (NCT04520802)
- Testing
- 18F-DPA-714 PET/CT neuroimaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Cognitive Decline
Mind-motor Exercise to Improve Cognition and Functional Fitness
This is a 3 month cluster randomized controlled trial using a square-stepping exercise program (a.k.a. mind-motor exercise) in retirement and long-term care residences to improve global cognitive functioning in older adults with…
- Trial name
- MIND-FUN (NCT02730013)
- Testing
- Square Stepping Exercise
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Huntington Disease
Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease
WVE-HDSNP2-002 is an open-label extension (OLE) study to evaluate the safety, tolerability, PK, PD, and clinical effects of WVE-120102 in adult patients with early manifest HD who carry a targeted single nucleotide polymorphism…
- Trial name
- NCT04617860
- Testing
- WVE-120102
- Where
- 20 sites in Australia, Canada and 5 more
- Volunteers
- 36 people
- Sponsor
- Wave Life Sciences USA, Inc.
Fibromyalgia
Cognitive Functions in Patients With Fibromyalgia
Accumulating research with human adults suggests that a single session of physical exercise ameliorates different aspects of cognitive function immediately after the end of the exercise period, regardless of fitness level.
- Trial name
- NCT05926986
- Testing
- Exercise, control
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Mild Cognitive Impairment
Beta-Amyloid Imaging With [18F]NAV4694 PET in Predicting Progression to AD in Subjects MCI
To investigate whether [18F]NAV4694 positron emission tomography (PET) scan findings have the ability to distinguish subjects with mild cognitive impairment (MCI) who progress to Alzheimer's disease (AD) from those who do not.
- Trial name
- NAV4-04 (NCT01812213)
- Testing
- [18F]NAV4694
- Where
- 11 sites in United States
- Volunteers
- 76 people
- Sponsor
- Navidea Biopharmaceuticals
Mild Cognitive Impairment
The Effect of TPS on Cognitive Functions in Older Adults With MCI
The goal of this randomized controlled trial is to learn if Transcranial Pulse Stimulation (TPS) can improve cognitive functions in older adults with mild cognitive impairment (MCI). The study will also assess the safety of TPS.
- Trial name
- NCT06407141
- Testing
- transcranial pulse stimulation
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment (MCI), Mild Alzheimer Disease
iTBS in MCI and Mild AD
This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.
- Trial name
- NCT06670820
- Testing
- Active rTMS
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Parkinson Disease, Dementia
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
This study evaluates the benefits of exoskeleton-based exercise for improving mood and cognition in people with Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT03583879
- Testing
- Exoskeleton exercise, Standard exercise, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- University of New Brunswick
Major Depression, Dementia
Neurocognitive Outcomes of Depression in the Elderly
Late-life depression (LLD) and cognitive impairment (CI) are significant public health problems among older adults, and their co-occurrence markedly increases disease burden and dementia risk.
- Trial name
- NCODE (NCT00570583)
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Schizophrenia, Psychosis
Social Cognitive Training for Psychosis: Treatment Development
The primary aim of this proposal is to develop, refine, manualize and assess the feasibility and preliminary efficacy of a brief, narrowly-focused social cognitive intervention for individuals with psychosis.
- Trial name
- NCT01579422
- Testing
- social cognitive training
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Yale University