Clinical trials: Cognition Disorders in Old Age
Healthy
Effects of Dietary Interventions on the Aging Brain
The researchers will investigate whether caloric restriction or dietary supplementation could provide positive effects on general brain functions in healthy elderly people.
- Trial name
- NCT00996229
- Testing
- Caloric restriction, Omega-3 (fish oil capsules), Resveratrol
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Cognitive Impairment, Cognitive Decline
A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults
The potential impact of various dietary ingredients to improve cognitive function, mood, well-being, and overall levels of affects are largely undetermined.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders in Old Age, Well-Being, Psychological
- Trial name
- COG (NCT05994391)
- Testing
- LasoperinTM, Placeo
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Depression, Cognition Disorders
Therapy for Depressed Elders With Thought Problems
This study will compare the effectiveness of Problem Solving Therapy and Brief Supportive Therapy in treating elderly patients with major depression and thought problems.
- Trial name
- NCT00052091
- Testing
- Problem Solving Therapy, Brief Supportive Therapy
- Where
- 2 sites in United States
- Volunteers
- 221 people
- Sponsor
- University of Washington
Alzheimer's Disease
Phase 1 Study Investigating Effects of HTL0009936 on Cognition and BOLD fMRI Signals in Healthy Elderly Subjects
To determine if treatment with HTL0009936 will lead to changes in neural activity, measured using the fMRI BOLD signal and ASL, in brain areas that are associated with spatial and working memory, learning and executive…
- Trial name
- NCT02546310
- Testing
- HTL0009936
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Cerebral Saturation, Cognitive Impairment
The Association Between Variation in Oxygen Saturation (ScO2) and Incidence of Postoperative Cognitive Dysfunction (POCD) in a Population of Elderly Patients Admitted for Emergency Surgery.
There is no study of the association between ScO2 and POCD in non-cardiac, thoracic or vascular surgery. The few studies found in cardiac, thoracic and vascular surgery show an incidence up to 50% with a variation of the ScO2…
- Conditions
- Cerebral Saturation, Cognitive Impairment, Emergencies
- Trial name
- NIRS-1 (NCT03107260)
- Testing
- To evaluate the relationship between oxygen saturation and the incidence of postoperative cognitive dysfunction in emergency surgery in elderly patients
- Where
- France
- Volunteers
- 181 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cognitive Impairment, Aging
Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP…
- Trial name
- NCT06029920
- Testing
- Overground Walking
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Mild Cognitive Impairment, Cognitive Decline
Effects of Walkasins on Gait Speed of Individuals With Mild Cognitive Impairments
The primary aim of this pilot study is to investigate the effect of Walkasins, a wearable lower-limb sensory prosthesis, on the gait speed and balance function of participants with mild cognitive impairment as measured by the…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Gait Disorders in Old Age
- Trial name
- NCT05723822
- Testing
- Walkasins
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- RxFunction Inc.
Cognitive Impairment
Preoperative Survey
This study will examine preoperative concerns in older adults through the use of a self-administered questionnaire. The development of this questionnaire will involve adapting survey questions from previously validated studies…
- Trial name
- NCT05653154
- Where
- 2 sites in Canada
- Volunteers
- 264 people
- Sponsor
- University Health Network, Toronto
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Plaque, Amyloid, Cognitive Deficits
Amyloïd Load in Elderly Population: Effect of Cognitive Reserve
This research aim to explore relationships between the presence of amyloid burden and cognitive performance, and its modulation by educational level.
- Trial name
- EDUMA (NCT02196116)
- Testing
- PET, MRI, neuropsychological tests
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Frail Elderly Syndrome
HOPE (Healthy Older People Everyday) To Age in Place
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented…
- Trial name
- NCT03797352
- Testing
- Multicomponent exercise
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Aging, Postoperative Cognitive Dysfunction
Postoperative Cognitive Function and EEG
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of…
- Conditions
- Aging, Postoperative Cognitive Dysfunction, EEG With Periodic Abnormalities
- Trial name
- POEM (NCT04219033)
- Testing
- EEG(Electroencephalogram) change
- Where
- 18 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Air Force Military Medical University, China
Cognitive Impairment, Depression
The Efficacy of Omega-3 Fatty Acids in Maintaining Optimal Mental Health in Elderly People
The efficacy of EPA-DHA supplementation will be assessed in a randomized placebo-controlled trial with cognitive decline and early signs of depression as primary outcome measures.
- Trial name
- NCT00124852
- Testing
- n-3 Fatty Acid Supplementation
- Where
- Netherlands
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Apathy, Bipolar Disorder
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
The goal of this clinical trial is to identify reliable markers of apathy in elderly subjects with bipolar disorder, age between 70 and 85 years, in order to accurately identify subjects at high risk of progressing to dementia by…
- Trial name
- ANACONDA (NCT06914284)
- Testing
- Actigraphy and MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Postoperative Cognitive Dysfunction
Transcutaneous Electrical Acupoint Stimulation for Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) is one of the common complications of cancer patients after operation with a 8.9%-46.1% incidence, which severely affecting patients' postoperative recovery, increasing the medical cost…
- Trial name
- NCT04606888
- Testing
- Transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Quality of Life, Cognitive Impairment
Effect of the Mindfulness-Based Health Promotion Program (MBHP) in the Elderly: a RCT
According to the World Health Organization (WHO), it is estimated that by 2025 the number of older people in Brazil will be approximately 33.4 million and it will be the sixth population in absolute numbers of the elderly in the…
- Conditions
- Quality of Life, Cognitive Impairment, Psychological
- Trial name
- NCT03706807
- Testing
- Mindfulness-Based Intervention, Cognitive Stimulation
- Where
- Brazil
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Centro Mente Aberta de Mindfulness
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Postoperative Delirium (POD), Postoperative Cognitive Deficit (POCD)
Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)
The research leading consortium to these results has received funding from the European Union Seventh Framework Programme [FP7/2007-2013] under grant agreement no 602461 (www.biocog.eu).
- Trial name
- BioCog (NCT02265263)
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 1,054 people
- Sponsor
- Charite University, Berlin, Germany
Mild Cognitive Impairment
Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment
This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.
- Trial name
- Neurofeedel (NCT03855319)
- Testing
- SMR neurofeedback training to MCI
- Volunteers
- 20 people
- Sponsor
- Fabienne Marlats