Clinical trials: Cognition Disorders in Old Age
Mild Cognitive Impairment
NEUROFEEDBACK TRAINING FOR OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: A PILOT STUDY
The purpose of this study is to evaluate the effects of SMR neurofeedback training on cognitive performance and electrical brain activity in elderly with cognitive impairment.
- Trial name
- NEUROFEEDEL (NCT04027725)
- Testing
- Neurofeedback
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment
Art Therapy and Music Reminiscence Activity in the Prevention of Cognitive Decline
The objective of this study is to determine the impact of Art Therapy and Music Reminiscence Activity on cognition in community living elderly with Mild Cognitive Impairment (DSM V: Mild Neurocognitive Disorder) using a…
- Trial name
- NCT02854085
- Testing
- Art Therapy, Music Reminiscence Activity
- Where
- Singapore
- Volunteers
- 68 people
- Sponsor
- National University of Singapore
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Sarcopenia in Elderly, Rehabilitation Exercise
Effectiveness of Smart-Assisted Rehabilitation Exercise Training on the Physical and Mental Health of Older Adults in Long-Term Care Facilities
The purpose of this clinical trial is to evaluate the effectiveness of a smart-assisted rehabilitation system on the physical and mental health of elderly residents in long-term care facilities through exercise training.
- Conditions
- Sarcopenia in Elderly, Rehabilitation Exercise, Long Term Care
- Trial name
- NCT07197528
- Testing
- Experimental Arm：Smart-assisted rehabilitation exercise system Control Arm：Usual care or routine physical activity
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Aging, Depression
Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)
The goal of this clinical trial is to learn if a combination of non-drug treatments works to benefit memory, thinking, and brain functioning in older individuals with recurrent depression.
- Conditions
- Aging, Depression, Cognitive Symptoms
- Trial name
- NCT07527273
- Testing
- Depression Cognitive Training, Non-Specific Cognitive Training, tDCS (active stimulation)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Vanderbilt University Medical Center
Mild Cognitive Impairment
Effects of Alpha-lactalbumin Intake on Metabolic and Cognitive Functions in Elderly
Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic…
- Trial name
- NCT02082418
- Testing
- Alpha-lactalbumin, Whey, Casein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Mild Cognitive Impairment (MCI)
Unlock the Secrets of Ageing Brains Through P300 Brain-computer Interface Games
The study will investigate the use of Electroencephalography (EEG) in understanding mild cognitive impairment (MCI). EEG is commonly used in everyday clinical practice for the assessment of a wide range of neurological disorders.
- Trial name
- NCT06628427
- Testing
- MoCA Test, Random Dot Motion (RDM) task, P300-BCI task without feedback
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Sheffield
Alzheimer's Disease, Mild Cognitive Impairment
Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly
The primary objective is to examine the efficacy of 8-weeks of a locally developed brain-computer interface based system (BrainpalTM)intervention for improving attention and memory in normal elderly.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Age-Related Cognitive Decline, Dementia
- Trial name
- 3ECog (NCT01661894)
- Testing
- BrainPalTM
- Where
- Singapore
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Cognitive Impairment, Cardiovascular Risk Factor
Cognitive Impairment and Cardiovascular Risk in Older
The objective of this project is to study cognitive yields in people of the town of Salamanca over 65, with particular emphasis on the acquisition of the initial symptoms of cognitive impairment in order to detect mild cognitive…
- Trial name
- DECRIVAM (NCT01327196)
- Where
- Spain
- Volunteers
- 327 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Early Onset Alzheimer Disease, Alzheimer Disease
Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
Obstructive sleep apnea (OSA) is much more common in the elderly than in the young; the latest studies show prevalence between 45% and 62% in individuals over 60.
- Conditions
- Early Onset Alzheimer Disease, Alzheimer Disease, Obstructive Sleep Apnea Syndromes
- Trial name
- AZAP (NCT01400542)
- Testing
- CPAP Treatment, No treatment
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Geriatric Patient Care Improvement, Postoperative Delirium (POD)
The Effects of Anesthesia Depth Monitoring on Postoperative Recovery and Cognitive Functions in the Geriatric Patient Population
This study will be conducted on patients aged 65 and older scheduled for surgery due to lumbar or cervical disc herniation. General anesthesia is routinely used for these types of surgeries in the hospital.
- Conditions
- Geriatric Patient Care Improvement, Postoperative Delirium (POD), Burst Suppression
- Trial name
- NCT06844279
- Testing
- Control Group: Standard Hemodynamic Monitoring, Processed Electroencephalogram (BIS Index), Processed Electroencephalogram (DSA Mode)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Aslıhan Güleç
Mild Cognitive Impairment
The Effect of Daily Consumption of Eggs on Cognitive Function in the Elderly
Cognitive impairment is also a major risk factor for development of dementia later in life. Findings from our studies suggest that the carotenoids, lutein and zeaxanthin may be important in cognitive function in the elderly.
- Trial name
- NCT01621646
- Testing
- eggs or egg whites
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tufts University
Behavioral Disorder, Music Therapy
Music Therapy and Psycho-behavioral Disorders in the Elderly Population
Since the 1990s, neuroscience, with functional MRI, has made it possible to understand the beneficial neurophysiological effect of music on man and his brain.
- Trial name
- DEMUse (NCT04702594)
- Testing
- Music therapy session via tools validated by MUSIC CARE
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hospices Civils de Lyon
Necrosis of Femoral Head, Knee Osteoarthritis
Probiotics Attenuate Postoperative Cognition Decline
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Neck of Femur, Lumbar Disc Herniation
- Trial name
- NCT04017403
- Testing
- Bifidobacterium triple live capsule
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Postoperative Cognitive Dysfunction
The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients
The goal of this clinical trial is to compare the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients undergoing surgery.
- Trial name
- NCT06353516
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Chung-Ang University Gwangmyeong Hospital
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postoperative Cognitive Dysfunction, Delirium
Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction
Despite an ongoing controversy in the scientific literature, the link between anesthesia and dementia and/or cerebral atrophy remains unclear.
- Conditions
- Postoperative Cognitive Dysfunction, Delirium, Dementia
- Trial name
- POCD-MRI (NCT02045004)
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nicolai Goettel
Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances
TEAS on Sleep Quality and POCD in Elderly Patients
Elderly patients are often considered as a high-risk population for major abdominal surgery due to reduced functional reserve and increased comorbidities.
- Conditions
- Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances, Postoperative Cognitive Dysfunction, Elderly Patients
- Trial name
- NCT04850196
- Testing
- TEAS, control group
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
Diabetes Mellitus
Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk
An urgent need exists to identify effective interventions to arrest or reverse dementia and cognitive loss at its earliest stages.
- Trial name
- NCT03036254
- Testing
- HBOT intervention
- Where
- 4 sites in United States, Israel
- Volunteers
- 155 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression, Cognition
Study of Duloxetine in Elderly Patients With Major Depressive Disorder
A study of the safety and efficacy of duloxetine in elderly patients (greater than 65 years old) with major depressive disorder
- Trial name
- NCT00062673
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Eli Lilly and Company