Clinical trials: Cognition Disorders in Old Age
Cognitive Dysfunction, Motor Skills Disorders
Impact of Sociodemographic, Psychological, and Quality of Life Factors on Dual-Task Performance in Elderly Iraqis
This study investigates the impact of sociodemographic, psychological, and quality of life factors on dual-task performance in elderly individuals living in Iraq.
- Conditions
- Cognitive Dysfunction, Motor Skills Disorders, Aging
- Trial name
- SociQ-DT (NCT06476561)
- Testing
- - Sociodemographic Assessment - Psychological Assessment - Quality of Life Assessment - D
- Where
- Turkey (Türkiye)
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Delirium, Cognitive Impairment
Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement)
There is lack of attention to preoperative cognitive function and delirium in elderly who underwent surgery. The investigators are investigating different tools that can help to screen for cognitive dysfunction and delirium in…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Dysfunction, Cognitive Dysfunction, Postoperative
- Trial name
- NCT05209555
- Testing
- MoCA, BAMCOG, DeltaScan
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Organ Protection
Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery
The purpose of this study is to investigate the effects of intravenous lidocaine on serum miRNA-135a and its downstream proteins Rock2 and Add1 in elderly patients undergoing non-cardiac under general anesthesia.
- Trial name
- NCT05503043
- Testing
- Lidocaine, Normal saline
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Hip Fractures
Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture
Elderly patients with hip fracture are older and have a high incidence of perioperative complications. the postoperative recovery of elderly patients with hip fracture is affected by hemodynamic instability and pain caused by…
- Trial name
- NCT05304559
- Testing
- S-Ketamine, Continuous iliac fascia space block, Normal saline
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Frailty, Sarcopenia
Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty
Sarcopenia and physical frailty are highly prevalent among institutionalized older adults and are major contributors to functional decline, reduced mobility, and loss of independence.
- Conditions
- Frailty, Sarcopenia, Aging, Malnutrition Elderly
- Trial name
- MULTI-FRAIL (NCT07275996)
- Testing
- Creatine Monohydrate, Multicomponent Exercise Program, β-Hydroxy-β-Methylbutyrate (HMB)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Burgos
Mild Cognitive Impairment, The Cognitive Normal Elderly
The Effects of Multidomain Non-pharmacological Interventions on the Elderly With or Without Mild Cognitive Impairment
The study aiming to investigate the efficacy, safety, and potential mechanism of a multimodal intervention on cognitive function in individuals with MCI or the cognitive normal elderly living in a community.
- Trial name
- NCT05483790
- Testing
- the multimodal intervention
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Diabetes Mellitus, Type 2
Computerized Cognitive Training for Diabetic Elderly Veterans
Computerized cognitive training (CCT) is an intervention has improved cognitive functioning in the elderly with and without cognitive impairment.
- Trial name
- CCT_DEV (NCT01736124)
- Testing
- computerized cognitive training, control games
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment
Memory Aid - Working Memory Training in Patients With Mild Cognitive Impairment.
Background: Mild Cognitive Impairment (MCI) is a condition characterized by memory problems more severe than normal cognitive changes due to old age, and less severe than dementia.
- Trial name
- MCI (NCT01991405)
- Testing
- Computerized Working Memory Training.
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Sorlandet Hospital HF
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Schizophrenia Disorders, Cognitive Impairment
Occurrence and Influencing Factors of Cognitive Impairment in Elderly Patients With Schizophrenia and
ACT combined with stratified intervention improved cognitive function and quality of life in elderly schizophrenia patients by enhancing psychological flexibility and family support.
- Conditions
- Schizophrenia Disorders, Cognitive Impairment, Acceptance and Commitment Therapy
- Trial name
- NCT06949657
- Testing
- the conventional treatment group, the ACT group
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Third People's Hospital, Huzhou City, Zhejiang Province, China
Traumatic Brain Injury, Aging
The Long-term Consequences After Traumatic Brain Injury in the Elderly
A better understanding of the injury patterns, injury severity, risk profiles, consequences and impact of Traumatic Brain Injury (TBI) in the elderly population is necessary due to the increasing incidence and prevalence of TBI…
- Conditions
- Traumatic Brain Injury, Aging, Cognitive Impairment, Quality of Life
- Trial name
- NCT04074850
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mild Cognitive Impairment, Overweight or Obesity
The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment
The prevalence of cognitive impairment in elderly obese patients is high, and the burden on families and society is heavy. Early intervention for mild cognitive impairment (MCI) is of great value.
- Conditions
- Mild Cognitive Impairment, Overweight or Obesity, Elderly
- Trial name
- NCT07395960
- Testing
- Metfomin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Fudan University
Cognitive Decline, Postmenopausal Disorder
Response of Sex Hormones and Different Functions to Exercise and Diet in Elderly Women
It is an interventional study in which 60 women estimated to enroll according to random allocation and divided into two groups. The study group will receive aerobic exercise in addition to diet restriction while the control group…
- Trial name
- NCT04492540
- Testing
- aerobic exercise and MIND diet program, MIND diet program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Cognitive Impairment
Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)
The purpose of this study is to use transcanial doppler (TCD) ultrasound to look for possible risk factors for ischemic brain injury.
- Trial name
- DISCoVeR (NCT03291340)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pennsylvania
Cognition Disorders in Old Age, Physical Activity
Brain Gym® Exercises for Institutionalized Elderly People With Cognitive Impairment
Scientific evidence regarding the effects of Brain Gym®, on people with cognitive impairment is scarce. This study aimed at comparing the effects of a program based on Brain Gym® exercises against a fitness exercise program on…
- Trial name
- NCT03368482
- Testing
- Brain Gym Exercises, Standard exercise program for institutionalized older adults.
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Vigo
Delirium, Postoperative Delirium
Stanford PIPRA Validation Study in an Elderly Orthopedic Population
The purpose of this study is to determine the accuracy of an AI-based tool in the prediction of postoperative delirium (POD), in a population at moderately high risk of developing this syndrome (i.e., elderly orthopedic…
- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Trial name
- PIPRA-ORTHO (NCT06567574)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postoperative Cognitive Dysfunction, Geriatrics
GDFT and Postoperative Cognitive Function in Geriatric Cancer Surgery
Postoperative cognitive decline remains a common and clinically significant complication among geriatric patients undergoing major abdominal cancer surgery.
- Conditions
- Postoperative Cognitive Dysfunction, Geriatrics, Abdominal Neoplasm, Hemodynamics
- Trial name
- NCT07438249
- Testing
- Masimo Root Hemodynamic Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Cognitive Intervention, Mild Cognitive Impairment
Cognitive Intervention for Cognitive Impairment
Mild cognitive impairment is characterized by cognitive dysfunction without impairment in instrumental activities of daily living, with aging being the primary risk factor.
- Conditions
- Cognitive Intervention, Mild Cognitive Impairment, Elderly Adults, Diabetes Mellitus
- Trial name
- NCT07747675
- Testing
- cognitive intervention
- Volunteers
- 102 people
- Sponsor
- Instituto Mexicano del Seguro Social
Postoperative Cognitive Dysfunction
Whole Genome Single Nucleotide Polymorphisms in Elderly Patients With Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) presents as a long-lasting decline in cognitive function following surgery. Recognized as an important neuropsychological complication of anesthesia and surgery, POCD occurs…
- Trial name
- GenPOCD (NCT02864173)
- Testing
- Whole genome small nucleotide polymorphism genotyping
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas