Clinical trials: Cognition Disorders in Old Age
Postoperative Delirium, Cognitive Function Abnormal
EEG Characteristics and Postoperative Delirium
The goal of this [type of study: observational study ] is to [compare Energy differences in various bands of intraoperative electroencephalogram in elderly patients with postoperative delirium and non delirium.] in [describe…
- Conditions
- Postoperative Delirium, Cognitive Function Abnormal, PSI, Frailty
- Trial name
- NCT06102967
- Testing
- delirium
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhuo Liu
Cognitive Dysfunction, Mild Cognitive Impairment
Cognitive and Physical Home-rehabilitation by Information and Communications Technology. Games for Older Adults Active Life (GOAL)
Aging is often associated with pathological pathway such as in Mild Cognitive Impairment (MCI), and that pathway may be associated to a high risk of dementia.
- Conditions
- Cognitive Dysfunction, Mild Cognitive Impairment, Vascular Cognitive Impairment
- Trial name
- GOAL (NCT03383549)
- Testing
- Tele-rehabilitation
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Post-Operative Confusion, Long Term Adverse Effects
Depth of Anaesthesia and Long-term Survival: The Balanced Anaesthesia Follow-up Study
Anaesthetic depth and complications after major surgery: an international, randomised controlled trial - The BALANCED trial. In this large, international, randomised controlled trial that enrolled patients aged 60 years and over…
- Conditions
- Post-Operative Confusion, Long Term Adverse Effects, Surgery--Complications, Cognitive Dysfunction, Postoperative
- Trial name
- BALANCEDLT (NCT04965324)
- Testing
- Anaesthesia Depth
- Where
- New Zealand
- Volunteers
- 6,644 people
- Sponsor
- Auckland City Hospital
Mild Cognitive Impairment
Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults
Cognitive impairment is also a major risk factor for development of dementia later in life. Findings from the investigators studies suggest that the carotenoids, lutein and zeaxanthin may be important in cognitive function in the…
- Trial name
- NCT01620567
- Testing
- avocado, potato or chickpea
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tufts University
Dementia
Computerized Cognitive Training in the Elderly
Background: The aging of the population has lead to a significant increase in the number of older people suffering from cognitive impairment and dementia.
- Trial name
- CogTrain (NCT00146263)
- Testing
- Savyon, Control
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Beersheva Mental Health Center
Neurocognitive Disorder, Etiology of Neurocognitive Disorder
Evaluation of Cognitive Impairment in the Elderly Admitted to Nursing Homes
This research aims at analysing the profile of the elderly with cognitive impairment (IC) and inquiring about the mental illnesses that cause cognitive impairment of a population (elderly admitted to nursing homes with a high…
- Trial name
- NCT05404152
- Where
- Spain
- Volunteers
- 390 people
- Sponsor
- Universidad de Murcia
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency).
- Trial name
- NCT00212147
- Testing
- General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mild Cognitive Impairment
Board Game Intervention to Improve Cognitive and Daily Functioning
Background: With the rapid rise of the aging population, the number of seniors with mild cognitive impairment (MCI) has increased, and without timely interventions, participants are at high risk of developing dementia.
- Trial name
- NCT04964011
- Testing
- Board game intervention
- Where
- Taiwan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Yang Shang-Yu
Aging, Cognitive Change
Test and Usability of Mixed-reality Screening Tool for Early Detection of Cognitive Declines
The aim of this study as part of the SCOBES-AR project is to establish and test a protocol for implementation and usability of mixed reality-enhanced multidisciplinary screening tool for early detection of cognitive impairments…
- Trial name
- SCOBES-AR (NCT05403814)
- Testing
- observational screening procedure (no intervention)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Healthy, Mild Cognitive Impairment
Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03227185
- Testing
- real anodal transcranial direct current stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mild Cognitive Impairment
Effects of Tai Chi Chuan With Different Doses on Cognitive Function in Elderly Patients With Mild Cognitive Impairment
To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.
- Trial name
- NCT06372535
- Testing
- Tai Chi Chuan （dose 1）, Tai Chi Chuan （dose 2）, Tai Chi Chuan （dose 3）
- Volunteers
- 540 people
- Sponsor
- Lidian Chen
Cognition Disorders in Old Age
Early Cognitive Function in Elderly Patients After Laser Laryngeal Surgery: Des vs Prop
Postoperative cognitive impairment is one of the most common complications in elderly surgical patients. Laser laryngeal surgery is a short procedure, but characterized by high risk of disastrous airway fire.
- Trial name
- POCDLLS (NCT03194074)
- Testing
- Propofol, Desflurane
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Brain Fog, Cognitive Impairment
Cognitive Task-Based Walking Effects on Cognition, Mood, Sleep, and Quality of Life in Older Adults With Brain Fog
This randomized controlled trial aims to investigate the effects of cognitive task-based walking exercise on cognitive function, depressive symptoms, sleep quality, and quality of life in older adults experiencing brain fog.
- Conditions
- Brain Fog, Cognitive Impairment, Geriatric Population
- Trial name
- NCT07396779
- Testing
- Cognitive Task-Based Walking Exercise, Walking-Only Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medipol University
Mild Cognitive Impairment (MCI)
Enhancing Attention in Elderly Using a Brain-Computer-Interface
Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology.
- Trial name
- NCT07441122
- Testing
- transcranial electrical stimulation, Mindfulness Meditation
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy Volunteers
Methylphenidate and Cognitive Training in Elderly
Currently, there is no available drug to treat the symptoms of neurodegenerative and vascular cognitive disorders that affect millions of people worldwide.
- Trial name
- PACTE-1 (NCT03280251)
- Testing
- Methylphenidate, CogniPlus software, Pseudo cognitive training
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cognitive Dysfunction, Cognitive Disorder, Dietary Supplements
INSIDE: Intervention in Nutritional Supplementation to Improve Cognitive Decline in Elderly.
This study investigates the effect of nutritional supplementation on cognitive performance in older adults over a 90-day period using a double-blind randomized controlled design.
- Trial name
- INSIDE (NCT07000500)
- Testing
- Nutritional Supplement
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Maria Paço
Dementia
IDEA Study Cognitive Stimulation Therapy (CST) Trial in Nigeria
This trials of cognitive stimulation therapy (CST) in Tanzania is part of the larger Identification and Intervention for Dementia in Elderly Africans (IDEA) study.
- Trial name
- IDEA (NCT02233530)
- Testing
- CST intervention
- Where
- Nigeria
- Volunteers
- 8 people
- Sponsor
- William Keith Gray
Mild Cognitive Impairment, So Stated, Mild Dementia
Cognitive/Physical Computer-Game Blended Training With Personalized Brain Network Activation Technology for the Elderly
The study involves a novel Virtual Reality Interface that offers full-body immersion "Alterniity AR" and more specifically computer exercises blended with game activities.
- Conditions
- Mild Cognitive Impairment, So Stated, Mild Dementia, Healthy
- Trial name
- AlterniityAR (NCT02417558)
- Testing
- Alterniity Augmented Reality (AAR), VideoGrade
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- XtremeVRI AG
Healthy Aging, Memory Disorders in Old Age
Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets
Alzheimer's disease and its preclinical stages are characterized by progressive neurodegenerative changes in the hippocampi and default mode network resulting in dysfunctions in episodic memory and its central part the…
- Conditions
- Healthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- Deep-HiPs (NCT05805215)
- Testing
- Non-invasive Temporal Interference stimulation and Face-name association training task targeting the hippocampus, Non-invasive Temporal Interference stimulation and Face-name association training task targeting the Precuneus
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Diabetes Mellitus, Type 2
The Effect of Choline Alfoscerate on Improvement of Cognitive Function in Elderly Patients With Diabetes
In this study, the investigators are going to investigate the efficacy of choline alfoscerate on improvement of cognitive function assessed by MMSE compared to plaebo.
- Trial name
- NCT03249259
- Testing
- Choline alfoscerate
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Bundang Hospital